Conserved Protein Domain Family
EB1_binding
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pfam05937: EB1_binding 
EB-1 Binding Domain
This region, found at the C-terminus of the APC proteins, binds the microtubule-associating protein EB-1. At the C-terminus of the alignment is also a pfam00595 binding domain. A short motif in the middle of the region appears to be found in the APC2 proteins.
Links
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Statistics
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PSSM-Id: 399141
Aligned: 5 rows
Threshold Bit Score: 252.996
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
P25054       2670 RSGRSPTGNTPPVIDSVSEKANPNIKDSKDNQAKQNVGNGSVPMRTVGLENrLNSFIQVDAPDQKGTEIKPGQNNPVPVS 2749 human
XP_015193203 2664 RSGKSPTGNTPPVIDSLPEKLIADDSDANDPQSKQPMVNENAPVRVLGLEN-VNSITKSEYTDKKGMDGKAAASNPGATP 2742
XP_014351222 2380 RSGRSPTGNTPPVIDNVPENMIKDEKDSKEMQAK-NAGNSNAPIH-VGLENrLNSFIQIDSPEKKASETKSMVVNPATTP 2457
XP_004910522 2668 RSGRSPTGNSPPVIDNVLDQGQKEEA-VKDCHTRHNSGNGNVPL----LENrQKSFIKLDGSDTKGTDPKTLINN---QQ 2739
XP_019465764 2096 RSGRSPTGNTPPVIDSVSEKGVVNGKDSKEIQEKQNPGNGSVPVRTIGLENrLNSFFQMDSPDKKGNETKPLQTNPVPAP 2175

P25054       2750 ETNESSIVERTPFSSSSSSKHSSPSGTVAARVTPFNYNPSPRKSSADSTSARPSQIPTPVNNNTKKRDSKTDSTESSGTQ 2829 human
XP_015193203 2743 ETHENPISERTPFSSSNSSKHSSPSGAVAARVTPFNYNPSPRKSSNDGTSARPSQIPTPVNSSTKKRDSKGEGVESSGNQ 2822
XP_014351222 2458 ETTENPVVERTPFSSTSSSKHSSPSGAVAARVTPFNYNPSPRKSSTENSSARPSQIPTPVNNSTKKRDSKTESTDSSGNQ 2537
XP_004910522 2740 ETNENTVAERTPFSSSSSSKHSSPSGTVAARVTPFNYNPSPRKSTAESSTSRPSQIPTPVTNSTKKRDSKTETTDSSGSQ 2819
XP_019465764 2176 ENNESTVSERTPFSSSSSSKHSSPIGAVAARVTPFNYNPSRRKSSVDNSSARPSQIPTPVNNSTKKRDSKSENTDSSGTQ 2255

P25054       2830 SPKRHSGSYLVTSV 2843 human
XP_015193203 2823 SPKRLSGSYLVTSV 2836
XP_014351222 2538 SPKRHSGSYLVTSV 2551
XP_004910522 2820 SPKRHSGSYLVTSV 2833
XP_019465764 2256 SPKRHSGSYLVTSV 2269
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