1TH1


Conserved Protein Domain Family
APC_r
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pfam05923: APC_r (this model, PSSM-Id:399133 is obsolete and has been replaced by 461781)
APC repeat
This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.
Links
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Statistics
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PSSM-Id: 399133
Aligned: 43 rows
Threshold Bit Score: 32.8088
Created: 27-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1TH1_C         10 SPPEHY-VQETPLMFSRCTSVSSL 32   human
XP_028026269 1234 ERVSRFvVEHTPAQFSANTSLSSL 1257 wild silkworm
XP_001955695  721 DKLNRFhVEHTPAVFSCATSLSNL 744  Drosophila ananassae
XP_017867251 1093 DDLSKFnVENTPAQFSGATSLSNL 1116 Drosophila arizonae
XP_011747092 1398 AGSVRFtVEKPDENFSCASSLSAL 1421 pig-tailed macaque
XP_022536604 1459 DTLIHFaTESTPDGFSCASSLSAL 1482 Mexican tetra
XP_014283782  792 DSVVAFkEESTPAQFSTATSLSDL 815  brown marmorated stink bug
XP_008198134  326 DAVKKFeTERTPSHFSTATSLSSL 349  red flour beetle
XP_001687753 1186 DELNPYyIEDSPCNFSTVSALSDL 1209 Anopheles gambiae str. PEST
XP_017142970 1231 DEMSKYlVEDSPCNFSVVSGLSNL 1254 Drosophila miranda
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