Conserved Protein Domain Family
L6_membrane
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pfam05805: L6_membrane (this model, PSSM-Id:399069 is obsolete and has been replaced by 461745)
L6 membrane protein
This family consists of several eukaryotic L6 membrane proteins. L6, IL-TMP, and TM4SF5 are cell surface proteins predicted to have four transmembrane domains. Previous sequence analysis led to their assignment as members of the tetraspanin superfamily it has now been found that that they are not significantly related to genuine tetraspanins, but instead constitute their own L6 family. Several members of this family have been implicated in human cancer.
Links
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Statistics
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PSSM-Id: 399069
Aligned: 98 rows
Threshold Bit Score: 113.794
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_006102833   1 MCTGQCARFVGLSLITLSLVCIVANALLLVPNGETTWt-NTDKLSLQVWLMAGFFGGGLMVLcPGIAAVRAGGKG-Ccga 78  little brown bat
XP_006142007   2 TCCEGWTSCNGFGLLVLLLFGIVLNAVPLIVNLVEEDklFESPISCFEWWFPGIVGAGVMVI-PATTMSLAARKRgC--- 77  Chinese tree shrew
XP_852211      2 TCCEGWTSCNGFSLLVLLLFGIVLNAIPLIVNFVDEGqfFHNPISCFEWWFPGIIGAGLMVI-PAATMSLAARKRaC--- 77  dog
XP_003474663   2 TCCEGWTSCNGFSLLALLLVGVVLNAVPLGINLVEQDriFQNPISCYEWWFPGIIGAGLMVI-PATTMSLAARKRgC--- 77  domestic guinea...
EHB18162       2 TCCEGWTSCNGFSLLALLLAGVILNAIPLGINLVEADkvFQNPISCFEWWFPGIIGAGLMVI-PATTMSLAARKRaC--- 77  naked mole-rat
Q9CQY8         2 TCCEGWTSCNGFSLLILILLGVVINCIPLGISLVEADstSQNPISCYEWWFPGIIGAGLMAI-PATTMSLAARKRaC--- 77  house mouse
XP_005326520   2 TCCEGWTSCNGICLLILLVIGVVLNAIPLGIDLVEQDkdFQNPISCYEWWFPGIIGAGLMVI-PATTMSLAARKRgC--- 77  thirteen-lined ...
XP_003417970   2 TCCEGWTSCNGFSLLVLLLLGIVLNAVPLIVSLVDEAqlLQNPISCFEWWFPGIIGAGAMVI-PATTMSLAARKRaC--- 77  African savanna...
XP_003766182   2 TCTEGFTSCNGFSLMVLALLAVVLNTIPLISYKLQSDelSKNPISCFEWWYPGIIGAGVLVI-PATIMSLAARKRaC--- 77  Tasmanian devil
XP_003785119   2 TCCEGWTSCNGFGLLVLLLLGVILNAIPLVMNLLEQDqfFQNPISCFEGWFPGIIGAGLM-------------------- 61  small-eared galago

XP_006102833  79 gcCGNRCRMLRSVFCSALGMIGAIYCLSVSGTGLRDGPK-CLLKDGs-----WDtpFKK-----------TEESYLFNRT 141 little brown bat
XP_006142007  78 --CNNKTGMFLSSLLNVITIIGAVYCMLVSIQALAKGPLiCNTPGNtn--ceFS--LKNlsdi---qpesFNLHWFFNDT 148 Chinese tree shrew
XP_852211     78 --CNNRTGMLLSSLLNVITIIGAVYCILVSIHALIEGPLiCNSEGNstsnceFS--FSNlsdt---hpefFNLQWFYKES 150 dog
XP_003474663  78 --CNNKTGMFLSSLLNVITIIGAVYCVLVSVQALSEGPLiCNSQVNgtvkceFS--LKNlsni---hsksFNLQWFLNDS 150 domestic guinea...
EHB18162      78 --CNNKTGMFLSSLLNVITVIGAAYCMLVSIQALSEGPLvCNSQVNgtanckFS--WKNltdi---hlqpLFLQWFWNDS 150 naked mole-rat
Q9CQY8        78 --CNNKTGMFLSSLFSVITVVGAVYCMLVSLQALLEGPLiCNTQANstvtceFS--LKNlskf---dpesFNLLWFFNGT 150 house mouse
XP_005326520  78 --CNNRTGMLLSSLLNAITVIGAVYCLLVSIQALSEGPLiCNSPSNstttceFS--LKNltdf---hpksFNLQWFFNDS 150 thirteen-lined ...
XP_003417970  78 --CNNKTGMFLSSLLNVVTVVGAVYCILVSTQALSEGPLfCNSPGNstfscqFS--WKNlsni---hpesFDLQWFFNDS 150 African savanna...
XP_003766182  78 --CNNRLGMILSSFLSLVTIGGAVYCILVSALALSEGPLiCNYNGNstfnceFS--MKNlsdihdqlqqpITLRWFFSPT 153 Tasmanian devil
XP_003785119  62 --------MFLSSLFSVITILGAVYCMVVSLQALSEGPLvCSLPANssaqceFS--FKNltni---hpesFTLQWFYNNS 128 small-eared galago

XP_006102833 142 lwdlCQEPP---------------------------NVVTWHVTLFSLLLAASCLELVLCGVQVVNAAVGVLCGDCR 191 little brown bat
XP_006142007 149 ----CVPPGnsnipntnntwpsnwtaysldfsseedKRRIIHFATFLGLLLVGILEVLFGLSQIVIGFLGCLCGVSR 221 Chinese tree shrew
XP_852211    151 ----CIAPTdytnltvnsimpsgwrehslhfnskenKHRTIHLTVFLGLLLVGILELLVGFSQIVIGFLGCLCGVTK 223 dog
XP_003474663 151 ----CVSPTghknsnpsdnmga--swkipssgseedRYRIVHFAVFLGLLLVGALEILCGLSQIVIGLFGCMCGVSK 221 domestic guinea pig
EHB18162     151 ----CVSPTgstklntnnnmst--swkipssnseedRYRIFHFSVFLGLLLVGILEALFGLSQIVIGFLGCLCGVSE 221 naked mole-rat
Q9CQY8       151 ----CVSPTdfknptinnmvs---nwkipnsnseedRHRIFHFSVFMSLLLVGILELLFGLSQILIGFLGCLCGVSQ 220 house mouse
XP_005326520 151 ----CVPPTgfpnsainnmhs---nwripnsnseedRQRIFHFSVFLSLFLVGVLELLFGLSQIVIGFLGCLCGVSg 220 thirteen-lined gro...
XP_003417970 151 ----CVPSTglsnsntasggs----kydqhinptenKYKIIHISAFTGLLLVGTLELLFALSQIVIGFLGCLCGGVs 219 African savanna el...
XP_003766182 154 ----C-EPEipnnsvpdnstnlfqrtntltvsseenRYKIIHLTVFVGLFLVGILEILFSISQIVIGLFGCLCGVSK 225 Tasmanian devil
XP_003785119 129 ----CLLPVlnnptf----------------sdttsQHTVIHFSVFLGLLLVGILEVLFGLSQIVIGFLGCLCGVSK 185 small-eared galago
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