Conserved Protein Domain Family
LMBR1
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pfam04791: LMBR1 (this model, PSSM-Id:398455 is obsolete and has been replaced by 461429)
LMBR1-like membrane protein
Members of this family are integral membrane proteins that are around 500 residues in length. LMBR1 is not involved in preaxial polydactyly, as originally thought. Vertebrate members of this family may play a role in limb development. A member of this family has been shown to be a lipocalin membrane receptor
Links
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Statistics
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PSSM-Id: 398455
Aligned: 79 rows
Threshold Bit Score: 132.396
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
P34535        67 RQQIICMWLFMLLYLFAYWLISRLKRKTEREAlyagee--dyfvyrVSVWISSTATATSIGSLTLLPFSVIGVell--ql 142  Caenorhabditis...
Q86AH0        92 REGIVSSIFFLILMIFSHFIIRRYIRKKDDEKki-----------yIPRLLCTVCLSISISAMLLIPITIISNeim--tt 158  Dictyostelium ...
EXX64430      25 RQNIIAFLLFVSLYSISYSLLQRFRRKNRITDieeeeddpygidslIIIILCAGGLAMALAGFLLWPFTMIATallhnei 104  Rhizophagus ir...
EEC43650       5 FLIVATVVAIVILLIIASYLLVHYQHPDDHNda------------yVPKLIVLLGFVLAGATVLMLPLDVANNe------ 66   Phaeodactylum ...
EFN58402       4 FLIIITVVVAILVLLVSLYLVVHFQHPEDKNqa------------wLPKLVVLLGFSVAFWTILLFPLDVANQqa----- 66   Chlorella vari...
XP_009392724   7 ALLIVAVVVSALVLLVSVYLLVNYQHPDDHNqa------------yFPKLVVVLGISIAAISILMLPADVANRqa----- 69   wild Malaysian...
BAJ85289       7 ALVIVAAVVSVLVLLVSVYLLVNYQHPDDANqa------------yFPKLVVVLGITVAVLSILMLPADVANRqa----- 69   domesticated b...
Q9SR93         7 ALVIVAIVVCVIVFISSIYLLVNYQHPDDANqa------------yFPKFVVVFGLSIAMISILMLPADVANRha----- 69   thale cress
XP_002967454   7 ILLIIVIVVTVLVFLFNTYLLVNYQHPDDHNqa------------yFPKAVVVFGLSVAQLSILMLPADVANRha----- 69   Selaginella mo...
EFJ25483       6 VLLVIVVLLTLLVFAINIYILIRYQHPDDSNqa------------yLPKIIVVIGLSIAQLSILMLPADVANRhs----- 68   Selaginella mo...

P34535       143 yDGNYYLQWLSYSL-IGALWNYVFVLSNVSLFVLLPFSYFFIESQGFSTSKIGnd-----mtQRIYEAMAISFLFAFVLL 216  Caenorhabditis...
Q86AH0       159 fPSSYYTQWLDREL-IFSFWNKIFWGANISLFIILPFTYFLYESEGIRGRSLL---------NRIKEALLILLLVAVIFV 228  Dictyostelium ...
EXX64430     105 fSGNYYLTWLDVEL-LVTLWNYAFIGCNISLFALLPFAFFYSETDQLRTFF-----------AKARETLIIMGLVGMLMY 172  Rhizophagus ir...
EEC43650      67 gYAGYDTGLCG-GLnMELMWDIVFWMIPIWVFVLIPFATFYYEADDGMLmagtayapnpvrqSRI-GQAICYQLFVFVII 144  Phaeodactylum ...
EFN58402      67 cELDIPLSSCS-TMpMKELWYAMYIANMAITFIAVPFCIFYYEADSDWSv-----------fRRS-LSGALWAAGTVFVM 133  Chlorella vari...
XP_009392724  70 cRHAIYNGACSLTLpMKQLWLAVYIADAILVFFVIPFAMFYYEGDQDKGi-----------gKRL-KSALLWVVTSAIVC 137  wild Malaysian...
BAJ85289      70 cKRAVYSGACSLTLpMKTLWLVVYIIDAVLVFLVIPFAMFYYEGDQDKSv-----------gKRL-KSALIWVVASAVVC 137  domesticated b...
Q9SR93        70 cRHAIYNGACNLTLpMKDLWLAIYIVDAILVFFVIPFAMFFYEGDQDKTl-----------gKRI-KSALIWVVTTAVVC 137  thale cress
XP_002967454  70 cQRALYNGACDLTLpMKDLWYAVYIIDAVLVFLVIPFTMFYYEGDQEKSv-----------aRRA-VGALMWVIVIAIVV 137  Selaginella mo...
EFJ25483      69 cEKNLYVGACKLTLpMKQLWWAVYIIDTVLVYLVIPFAIFFYEGDQEKTv-----------tQRI-KNALLWVVILLTVF 136  Selaginella mo...

P34535       217 CLAEVVLTIl--------------------------------------------------------------dYPVSFLs 234  Caenorhabditis...
Q86AH0       229 GFVFVVFKLfygqq------------------------------------------------------kqpstLMENISi 254  Dictyostelium ...
EXX64430     173 GFIYTLKMLf------------------------------------------------------------------GISn 186  Rhizophagus ir...
EEC43650     145 GVIFAVTYIslsdskipvqeyvgpalgkvnqgftysaqr----natddllpfdsdglqpwgdsdttylsnvvdNGEQTLv 220  Phaeodactylum ...
EFN58402     134 AILIGIPYAfagnaqytvqgarsgllpisylsnaedsftnciglfsyydqdsgqpklnstlvslgyncdtlinQLSEVWt 213  Chlorella vari...
XP_009392724 138 GLLLGILYGlvgkvdftvrhlsssaesfpssw------------------tgfsrsqpcisssrlcdayiapaTSEKTWt 199  wild Malaysian...
BAJ85289     138 GLVLGILYAligkvdftvrhlsssvqtfpgpnqf---------------gaftsgqpciapltrqcsantapaNSQTTWt 202  domesticated b...
Q9SR93       138 ALVLGILYGvigkvdfsvrhlasatstfptsw------------------qfsntqpcigntarqcsaftanpTSEKTWt 199  thale cress
XP_002967454 138 GLVLGILYGligkvdftvrhlssttigfttdysq---------------ltsrspclvptnspnacsaynagyGAEATWs 202  Selaginella mo...
EFJ25483     137 CLLLGILYAvigyadftvrrlssttlaftndfssl-------------nakapclfpagfslssncaaytsgsLVKTTWs 203  Selaginella mo...

P34535       235 ITsVNLPLIYSCVSFIGAVLLLISTPYGFAKM----FSLARdflvteetadieeenseqsedvtepknsssdetihqvdr 310  Caenorhabditis...
Q86AH0       255 IStDYLPFSYSLISTFGTVVVMYSIPSGFNFLiskcISLr---------------------------------------- 294  Dictyostelium ...
EXX64430     187 VDeLEMLNLFTCIG--GALICLKATPRGYIEI----FSCISklpl----------------------------------- 225  Rhizophagus ir...
EEC43650     221 LQvSLSTFYAGLMAWLGWFLFAIFGGIGLAALp---LDLYLmfknrprhmdaaef------------------------- 272  Phaeodactylum ...
EFN58402     214 IRvSIIVYAMAIVATLGWVLFMVFGGIGLVALp---IDWIRefiarpkat------------------------------ 260  Chlorella vari...
XP_009392724 200 MRtSFPEYVVALATIVGSVLFTIFGGVGIACLp---LGLIFsfirrpkav------------------------------ 246  wild Malaysian...
BAJ85289     203 MRaTFPEYVVALATIVGSVLFTIFGGVGIACLp---LSLIFsfvrrpkav------------------------------ 249  domesticated b...
Q9SR93       200 MRtTFPEYVVALATIVGSVLFTIFGGVGIACLp---LGLITafirrpkav------------------------------ 246  thale cress
XP_002967454 203 MRtTFPQYLIALTTIVGSVLFTIFGGVGIACLp---LSLIFaffkrptav------------------------------ 249  Selaginella mo...
EFJ25483     204 VRaPFPTYVIALNTIIGSILFTMFGGVGMATLp---LSLIFafknrpkcv------------------------------ 250  Selaginella mo...

P34535       311 sdtphledvvnditenvdadgefRKDSDSGIESGSTEEMRLNTDDEEMGindsddksafgddgdlgnstptknkkkrrkh 390  Caenorhabditis...
Q86AH0       295 ----------------------iVRPIEDEIKAAKMEIESITFTLDKAEaagfvnleikksklkkrllncsinsgnnnnn 352  Dictyostelium ...
EXX64430     226 -------------------rpnyRRSLKEKLKRNKMDITVWQQRLENLE------------------------------- 255  Rhizophagus ir...
EEC43650     273 ----------aeaqlslrervneMVDIGELIKIE---------------------------------------------- 296  Phaeodactylum ...
EFN58402     261 --------------itrsqyidrARDLA---RRA---------------------------------------------- 277  Chlorella vari...
XP_009392724 247 --------------itrsqyikgATDLG---KKA---------------------------------------------- 263  wild Malaysian...
BAJ85289     250 --------------itrsqyikeATELG---KKA---------------------------------------------- 266  domesticated b...
Q9SR93       247 --------------itrsqyikeATELG---KKA---------------------------------------------- 263  thale cress
XP_002967454 250 --------------itrsqyikeATILG---KRA---------------------------------------------- 266  Selaginella mo...
EFJ25483     251 --------------itraqyvkeATDLA---KRS---------------------------------------------- 267  Selaginella mo...

P34535       391 dyaattpivrkwdkdvpkkpknpnfdyRNLKEYVKEARRQRSSLSESDdywfgspprssfsanyyssrfsrwkhNSETGL 470  Caenorhabditis...
Q86AH0       353 nnnnnnnnnnnnnnnnngnncndnkveKKKDNKNKNEMKSDKKTNHSN--------------------------VNSDII 406  Dictyostelium ...
EXX64430     256 ---------------------------RGLRsiysvnn------------------------------------------ 266  Rhizophagus ir...
EEC43650     297 ---------------------------REQKaqaglt------------------------------------------- 306  Phaeodactylum ...
EFN58402     278 ---------------------------KDILal----------------------------------------------- 283  Chlorella vari...
XP_009392724 264 ---------------------------RELKkt----------------------------------------------- 269  wild Malaysian...
BAJ85289     267 ---------------------------KELKka----------------------------------------------- 272  domesticated b...
Q9SR93       264 ---------------------------RELKka----------------------------------------------- 269  thale cress
XP_002967454 267 ---------------------------RELKet----------------------------------------------- 272  Selaginella mo...
EFJ25483     268 ---------------------------NELKaa----------------------------------------------- 273  Selaginella mo...

P34535       471 Npsssllvdpfasgd-fheassseasstpLSPA----------------------------------------------- 502  Caenorhabditis...
Q86AH0       407 SsssspsspltpssplsqasnanesnstvNTPNiiatttnsniviindeynnnnnnnninfengnnsnnennnnidndnl 486  Dictyostelium ...
EXX64430     267 -----------------------tsrsaiLVPStesqysysseklya--------------------------------- 290  Rhizophagus ir...
EEC43650         --------------------------------------------------------------------------------      Phaeodactylum ...
EFN58402         --------------------------------------------------------------------------------      Chlorella vari...
XP_009392724     --------------------------------------------------------------------------------      wild Malaysian...
BAJ85289         --------------------------------------------------------------------------------      domesticated b...
Q9SR93           --------------------------------------------------------------------------------      thale cress
XP_002967454     --------------------------------------------------------------------------------      Selaginella mo...
EFJ25483         --------------------------------------------------------------------------------      Selaginella mo...

P34535       503 --------------------RRTKSEEAIWKPVLHTVKSSKLYKRAIEKQgrl----------------------vklFM 540  Caenorhabditis...
Q86AH0       487 etnienkkkinnylikkkkvNVNSNFKITPEEIQKLEDTRDELYLYIDKIsrp----------------------syfSS 544  Dictyostelium ...
EXX64430     291 -------sgianniitnrsgHLSNSRNEIIAKINKLEEEEKRLQKDLSHS------------------------------ 333  Rhizophagus ir...
EEC43650     307 --------------safatfSLNSDT--------RKAARDEN--QAVLGFkqavylleqdve-----dfqnatvnykkYN 357  Phaeodactylum ...
EFN58402     284 ------------------adALKREE--------RERGRSWRWRRNIKALnnqlivleedetqlelvypqsedpdykwVL 337  Chlorella vari...
XP_009392724 270 ------------------ieTLHQEE--------RSGSKGRKWRKNLKEAekelflleddmkaleemypqgeqaetvwAL 323  wild Malaysian...
BAJ85289     273 ------------------aeALHQEE--------RSGNKGRKWRKNVKAVekellllendmnaleemypqgekaeatwAF 326  domesticated b...
Q9SR93       270 ------------------adGLHQEE--------RSGAKGRKWRKNVKAVekellqleedvnlleemypqgeqaetawAF 323  thale cress
XP_002967454 273 ------------------tlALQREE--------RSSGKGRKWRKEMKKVqqellyleedvqrleeaypqgekadttwAL 326  Selaginella mo...
EFJ25483     274 ------------------tlGLQREE--------RGGKKGRKFRKNVKKVqqelvfleddvealneafpqgekadtswAL 327  Selaginella mo...

P34535       541 SLRFPVAAAAL----LVLTTCSLIMVATNTL----KLLFgyrsLP-----VYAQYIeVHTRHSFGLFGACIETLLIIYVM 607  Caenorhabditis...
Q86AH0       545 TLVRILSSILLtiinFTITGWVIFKVFITLIkrifELFElesiKAyfdswMSSAIDlSKGSSKLGPFESLLETTIIIYLM 624  Dictyostelium ...
EXX64430     334 ----PLYRNMLflvlFIVSHFIWLLILGHILyalmKSLLvddgKEl---kNLEALIgKQTVSLFG-FGTLNEITLIFCFT 405  Rhizophagus ir...
EEC43650     358 VLIPYIA-LLLslcaFIVSIFWFIHVIVYVFp-----------SPplapfLNNYFEwF--DKWFPLFGVLSVALFVSYLL 423  Phaeodactylum ...
EFN58402     338 TVMGFWLKFFGgllgLAMSICWVLQIILYILi-----------DPpvtplLNDMFIkA--NDAFPLFGTLLFGLFAFYLQ 404  Chlorella vari...
XP_009392724 324 TVLGYLAKFVLgvvgLIVSVAWVAHIVIYLLi-----------NPplspfLNEVFIkL--DSVWGLLGTAAFAIFCFYLL 390  wild Malaysian...
BAJ85289     327 TVLAYIGKLIFgivgLIVSIAWVAHIIIYLLv-----------DPplssfLNEIFIkL--DSVWGLLGTAAFAFFCFYLL 393  domesticated b...
Q9SR93       324 TVLGYLAKFILgivgLIVSIAWVAHIIIYLLv-----------DPplspfLNEVFIkL--DDVWGLLGTAAFAFFCFYLL 390  thale cress
XP_002967454 327 TVLGYLSKLLLglvgLVVSGAWVAHIIVYMLi-----------KPpfssfLNQVFIkL--DDVWGLLGTVAFAFFCLYLI 393  Selaginella mo...
EFJ25483     328 TVLFYLAKLVFgivgLALSIIWLLHIIVFMLv-----------NPpafpfLNQVFIqL--DSAWGLLGTTAFAIFCYYLV 394  Selaginella mo...

P34535       608 ITSFVGLYSL---PVLRSLRPv-RKDTPMPTIIINSSIVLVVASa--------------lPVAVNTVGMTTFDLLGSHSS 669  Caenorhabditis...
Q86AH0       625 ISAFVGFLNE---PYFANIKPr-IHSTSLRKMIINTGIILLMSSs--------------fPVVVRILEISRFDLMGYYSH 686  Dictyostelium ...
EXX64430     406 SATIIGVYSI---SPFKRIRPr-LGKMTVQQIIANVTVLLVISSs--------------wPVLVRVLGLTRLSSAGPYEN 467  Rhizophagus ir...
EEC43650     424 LAALKGCFKFgirFLFFHIHPmkVGKTYMSSFMFNIALVLLCALpavqfsqaafadyaafAEIRQIFGVQ---------- 493  Phaeodactylum ...
EFN58402     405 LCVTKGNFKFglnLLIFRVHPmrRGATIMSSFLFNVALILLATTasiqfctaafalyadgTAINDIFGNQ---------- 474  Chlorella vari...
XP_009392724 391 LAVIAGEMMLglkLVFFTIHPmkWGGTLMNSFLFNVGLILLCSIsviqfcasafayysqaTAAQEIFGHT---------- 460  wild Malaysian...
BAJ85289     394 IAVIAGEMMLglkLVFITIHPmkWGGTLMNSFLFNVGLILLCSIsviqfcatafayyaqaTAAQEIFGHT---------- 463  domesticated b...
Q9SR93       391 LAVIAGAMMLglkLVFITIHPmkWGATLMNSFLFNVGLILLCSIsviqfcatafgyyaqaTAAQEIFGHT---------- 460  thale cress
XP_002967454 394 LAVISGEMHLglnFGLIAIHPmkYGGTLMNSFLFNVGLILLCSVsviqfcskafalyaraTTAQEIFGLT---------- 463  Selaginella mo...
EFJ25483     395 MSVISGEMHLgmrLLFLSIHPmkYQGTLMNSFLFNVAIILLCSTsviqfctkafslyaeaTAAQEIFGHS---------- 464  Selaginella mo...

P34535       670 LQWLGsF--RVVVAYNTLFVVLSVAFLFNQL 698  Caenorhabditis elegans
Q86AH0       687 TNYLRgD--FFKIIYSISFLFMVIRSYMLSF 715  Dictyostelium discoideum
EXX64430     468 FSTMTnIgqYLAMAFRVSALITTVFSTLEYY 498  Rhizophagus irregularis DAOM 197198w
EEC43650     494 IQFLQfF--SFFWTNNVFIYCFLAFTVLTSI 522  Phaeodactylum tricornutum CCAP 1055/1
EFN58402     475 LSSIKgL--KYIYNENIFIYCLLGFMALTLV 503  Chlorella variabilis
XP_009392724 461 LQSLRgI--KYLYKYNVFQYGFVGFAVLTLF 489  wild Malaysian banana
BAJ85289     464 LQSLRgI--KYLYKYNVFQYGFVALAILTLF 492  domesticated barley
Q9SR93       461 LQSLRgI--KYLYKYNVFQIGFVILAGLTFL 489  thale cress
XP_002967454 464 LESLRgI--KYLFRYNVFQIAFCVLSVVTLV 492  Selaginella moellendorffii
EFJ25483     465 LESLRgL--KYLFIFNVFQIAFIVFAFLSFL 493  Selaginella moellendorffii
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