Q9W4A6 203 FLRVGAIAFGLGAMIYIGLEFG---SFFEI----PFDSPCHH-------------ILIGVNPLLQMIFTFMQMYFIFMNA 262 fruit fly CAP34165 158 YLRLGALFFGSVGIVLFGLELF---LCIEN--------ATCK-------------KVTIAKMIVAIIFTFIQMHFIFCNS 213 Caenorhabditis ... Q22977 146 YLRLGTVLFGTLGSVLWGCEIF---LCFFT--------ETRH-------------NIYVVKYILAFLFTYLQMHFLCCNS 201 Caenorhabditis ... XP_003110541 162 YLRLGALLFGTLGSVLWGCEIY---LCFAG--------ECVH-------------RLVVSKHIAAIIFTFLQMHFIVCNS 217 Caenorhabditis ... Q22976 160 YLRLGAIFFGTLGSVLWGCEIF---LCFSG--------ECVH-------------RLVVAKHIAAIIFTFLQMHFIVCNS 215 Caenorhabditis ... PDM84064 193 YLRIGCVVFGLIGVVYYVLMAL---VCTFGw--dGITANECN-------------ASGIAISVMAALFVFSQMWFVYCNG 254 Pristionchus pa... XP_002634537 177 FLRLGSVVFGVTGVVYYAFLVF---LCELD--------TNCS-------------ALSTSLDVCAIFFIFIQMHFIFCNW 232 Caenorhabditis ... ESN90352 137 FV-AGLVLFYTLSFVMDFVHLM-------------AKVDCSPvwmackynvkvtfIVDVIFHITRIVFFGCSTFFAIVYR 202 Helobdella robusta EFA02328 335 YLKIGAAVFCLGHLIHSGLLIGy--QILFLtsdgEDFYKCAT-------------VTSLILDIVYPIYSFFLLYFIFKYS 399 red flour beetle 6_pfamImport 1 YMKVGAAGFCLGHLIHSGLLISyqlAFLMTd--sANFLRCAS-------------IATLVLDLLYPTYSFLQLFFIFKYS 65
Q9W4A6 263 RLNIHR-FKVIARFGLMHVVATNICVWIRTLVKE-----SLLEITIYHQKN-EPEAGASSIAHSIRQHALRHAGTVLrth 335 fruit fly CAP34165 214 KITVNS-SRKIVAFGMMHLISVNLWTWFRFVLAKqeakaHKKAMLKQTFRKyYSSSSSSSSSEEI--------------- 277 Caenorhabditis ... Q22977 202 KIDLPK-NNFLASFGMMHCVAVNLWVWFSLCLAKavyksDKKT----------LKLQKAEEKYKKKNMTITEA------- 263 Caenorhabditis ... XP_003110541 218 KITFHR-SNHLASFGMMHCVAVNIWTWFSMCLVKaqvkrLKKQ----------KKEMEYHKNSTDSYSSSSSSSSSSsee 286 Caenorhabditis ... Q22976 216 KITFHR-SNILASFGMMHCVAVNLWTWFSMCLVKaqvkkLKKQ----------KKELEYHSSSSSSSDSSSSSEEILepe 284 Caenorhabditis ... PDM84064 255 KIAINGnSRYYISLGLMHLVATNLWLWIRYILYE--------EAQTLKEIR-LAKFDHNSTSTSDILQDL---------- 315 Pristionchus pa... XP_002634537 233 KLSITG-SHMVARIGTMHLVAANLWTWIRYVLMEegvmeKEIR----------EVFKHRPMMGHYRNLSFDSSESS---- 297 Caenorhabditis ... ESN90352 203 SFIFAS--KCWVRYSLAVLFGVNLALWFDVLLHE-------------------SARIINNSSSSAIIDNE---------- 251 Helobdella robusta EFA02328 400 NIIVNR-HLAVVRFGLMHCIASSLCFWVWTILRE-----TIESLSHHKEDS-ASEELPTTSESAFFSSPQ------A--- 463 red flour beetle 6_pfamImport 66 NVIINR-FKVAGRFALMHCIGSNLCFWIWTILREtvdslYHGE----------DAPVSLHHLNSHKAMYMTGMFLAVf-- 132
Q9W4A6 336 agpnsefevldgedilpkdvyksdnvlsklvrntvdgiskslgmggdqaldssttssstttttrapfttpnyqwhsttma 415 fruit fly CAP34165 -------------------------------------------------------------------------------- Caenorhabditis ... Q22977 -------------------------------------------------------------------------------- Caenorhabditis ... XP_003110541 287 edel---------------------------------------------------------------------------- 290 Caenorhabditis ... Q22976 -------------------------------------------------------------------------------- Caenorhabditis ... PDM84064 -------------------------------------------------------------------------------- Pristionchus pa... XP_002634537 -------------------------------------------------------------------------------- Caenorhabditis ... ESN90352 -------------------------------------------------------------------------------- Helobdella robusta EFA02328 -------------------------------------------------------------------------------- red flour beetle 6_pfamImport --------------------------------------------------------------------------------
Q9W4A6 416 rklkkfitsattaattaagssstasstttisptissttipsttisstTISSSTTFSPFSPSTTTTTTTTAAAlnletsgs 495 fruit fly CAP34165 278 ------------------------------------------------------------HELISAVLNSTI-------- 289 Caenorhabditis ... Q22977 264 ---------------------------------------------------VAETITTTIASIVSSESSSGFradekq-- 290 Caenorhabditis ... XP_003110541 291 -----------------------------------------esstvlEGLVEAVVEKMKPMMSSYSSSTSSY-------- 321 Caenorhabditis ... Q22976 285 --------------------------------------------sstLLENLIEVVLEKLKPGKGTTYTSTP-------- 312 Caenorhabditis ... PDM84064 316 -----------------------------------------------LAVDSHGGSHHDDNNSTDFIHALHT-------- 340 Pristionchus pa... XP_002634537 298 ------------------------------------------------QEQSSEMFSSHEDEHDKKIVGSCQ-------- 321 Caenorhabditis ... ESN90352 252 -------------------------------------------------------IIIIRCLQRNDSTDMQShn------ 270 Helobdella robusta EFA02328 464 -----------------------------------------------LPLISYDKRGAKLLTAYLNTTVRQF-------- 488 red flour beetle 6_pfamImport 133 -----------------------------------------------NSVYDQNIFKNREIPRNSVRQTALI-------- 157
Q9W4A6 496 espfgglqrilssaappslapvdgfgsasaatptsgsgagsfvdsflastlspasstegsasimnnlfgqgpmensfqty 575 fruit fly CAP34165 -------------------------------------------------------------------------------- Caenorhabditis ... Q22977 -------------------------------------------------------------------------------- Caenorhabditis ... XP_003110541 -------------------------------------------------------------------------------- Caenorhabditis ... Q22976 -------------------------------------------------------------------------------- Caenorhabditis ... PDM84064 -------------------------------------------------------------------------------- Pristionchus pa... XP_002634537 -------------------------------------------------------------------------------- Caenorhabditis ... ESN90352 -------------------------------------------------------------------------------- Helobdella robusta EFA02328 -------------------------------------------------------------------------------- red flour beetle 6_pfamImport --------------------------------------------------------------------------------
Q9W4A6 576 tdlgheeatglvsfenlesldniypaalssnigtlnSTAC--GRIDIMGTI-------------VYDSAPYLYPFIIEYS 640 fruit fly CAP34165 290 ------------------------------------------NNTPETKTVepaavsrlfalehFGDVATFLTTCIVEYS 327 Caenorhabditis ... Q22977 291 ----------------------------------------------------------lrslykLGSAANFLLTTMVEFS 312 Caenorhabditis ... XP_003110541 322 ------------------------------------------PTYSYNSTSnhtllr-mqsmarLGDFSSFLLTCLVEYS 358 Caenorhabditis ... Q22976 313 --------------------------------------------YPYTNSSnttsllrmqsmvrLGDFSSFLLTCLVEYS 348 Caenorhabditis ... PDM84064 341 ------------------------------------AHDC--KGVQCL----------------FGEFSEFMYTCVVEYS 366 Pristionchus pa... XP_002634537 322 ------------------------------------AVECf-----------------------LGSLSEIMFTSIVEYS 342 Caenorhabditis ... ESN90352 271 -----------------------------------fTIQCfgEETNIFKFL-------------NVSVVPLCYPFMYE-S 301 Helobdella robusta EFA02328 489 ------------------------------------VSEC--QNDAGLSLI-------------YRNYSPYLYPFSVEYS 517 red flour beetle 6_pfamImport 158 ------------------------------------LKKC--HGPMQFKIV-------------FETFSPYLYPFTIEYS 186
Q9W4A6 641 LIGAVVLYVMW--------------------------------------------------------------------- 651 fruit fly CAP34165 328 LIGAAIMFILW--------------------------------------------------------------------- 338 Caenorhabditis ... Q22977 313 LIAAAVYFIVW--------------------------------------------------------------------- 323 Caenorhabditis ... XP_003110541 359 LIGAAVCFIIW--------------------------------------------------------------------- 369 Caenorhabditis ... Q22976 349 LIGAAICFIIW--------------------------------------------------------------------- 359 Caenorhabditis ... PDM84064 367 LICAGVAFVFW--------------------------------------------------------------------- 377 Pristionchus pa... XP_002634537 343 LIAAAVMYIVW--------------------------------------------------------------------- 353 Caenorhabditis ... ESN90352 302 CVLLCERFMHWfchckrmsvrtsfkralkqpnqpsvdeetkveddnvtnvlgvnenneitiksdhlsepinenngsfylv 381 Helobdella robusta EFA02328 518 ILVVGVLFVIW--------------------------------------------------------------------- 528 red flour beetle 6_pfamImport 187 ILVVGVLFIMW--------------------------------------------------------------------- 197
Q9W4A6 652 ----------------------------------------------------------KHIGRYPGr---------mNDE 664 fruit fly CAP34165 339 ----------------------------------------------------------KSIGQNNHh---------qSNS 351 Caenorhabditis ... Q22977 324 ----------------------------------------------------------KHEGEQTPq---------dARK 336 Caenorhabditis ... XP_003110541 370 ----------------------------------------------------------KYMGATSIeen------vdKKK 385 Caenorhabditis ... Q22976 360 ----------------------------------------------------------KYMGATNIemk------vdKKK 375 Caenorhabditis ... PDM84064 378 ----------------------------------------------------------TNCGVhgegekidd-------- 391 Pristionchus pa... XP_002634537 354 ----------------------------------------------------------RNIGRQDHg----------STY 365 Caenorhabditis ... ESN90352 382 dssndeceldnkefssaedeneledeevitdesdlddhsfhdisdinqeannnndtssKNINQQVYvkscihsevsrEKM 461 Helobdella robusta EFA02328 529 ----------------------------------------------------------QSIGK-CKq---------kEEM 540 red flour beetle 6_pfamImport 198 ----------------------------------------------------------QNIGThkhcrnddw-------- 211
Q9W4A6 665 dlehrlevmls--------------------------------------rravamaqqaRSGRVDCVGSSKGLFFGL--- 703 fruit fly CAP34165 352 gk-------------------------------------------------------rkVKMRIDCSSSSTGLFAGI--- 373 Caenorhabditis ... Q22977 337 -----------------------------------------------------------KHVRFDCKSTSVGIFAAI--- 354 Caenorhabditis ... XP_003110541 386 -----------------------------------------------------------KKLRMDCTSTTVGLFAGI--- 403 Caenorhabditis ... Q22976 376 -----------------------------------------------------------KKLRMDCHNTTIGLFLGI--- 393 Caenorhabditis ... PDM84064 392 ---------------------------------------------------prpqrrkrNIVTIDCSRTAEGLFAGF--- 417 Pristionchus pa... XP_002634537 366 vk-------------------------------------------------------rkHQIRVDCSKTTTGLFLGL--- 387 Caenorhabditis ... ESN90352 462 dfhsradnsntaeaqnsscsemfdsatrdnsqqiivadneeannesrrndgqltgkhskRRLSKNISDSDRKMVGSLgca 541 Helobdella robusta EFA02328 541 sstrqcdtpv----------------------------------------gnndnlesnVVIHADCHSANKGLFSGI--- 577 red flour beetle 6_pfamImport 212 ---------------------------------------------------nsgdlmsnVVLYADCHSSNKGLFAGL--- 237
Q9W4A6 704 LLLVGALICLILFFVLVRHQQFSLLAIYLADA-SHCI--------------LMAFAILAIIVGFIRVKNLKFRCE----- 763 fruit fly CAP34165 374 IFLIGSLVSMGMYTIFETLRNSSG-AQLVFGI-VDLS--------------LFSIALGACVIGLWRMRLLQYRLH----- 432 Caenorhabditis ... Q22977 355 VLLIGSFISIAMHYIYNN-SDMPRTADEVIGI-AETV--------------LFCVCLLAVFGAFIRMRKLQYRLH----- 413 Caenorhabditis ... XP_003110541 404 FFMTAAFVTIGIYTMLYNKKNAAG-ADLVIGI-VNLV--------------LFCVALVAVIFGSWRMRVLQYRLH----- 462 Caenorhabditis ... Q22976 394 FFMTAAFVTIGIYTMLYNKKKTQS-ADLVIGI-VNLI--------------LFCVTLLATIFGAWRMRVLQYRLH----- 452 Caenorhabditis ... PDM84064 418 LFLICTILAVSLYNAYSTDA---YMAQLIFLS-TEIF--------------FYGVAIVVCCYAFWRMKVLAFNHDqdend 479 Pristionchus pa... XP_002634537 388 AFLAVTFTSMVVYYGFTMMNKSKD-AAFVYAF-TDMF--------------QYVLSTIGVLTAIYQMRALKYFNKkthiq 451 Caenorhabditis ... ESN90352 542 LFFLFTISTNVLFFIFSLLP----GAIQKNDLsAEVKhdvinrlflyytipFYGSIIISVIYGFTVAKDFPLRRSniint 617 Helobdella robusta EFA02328 578 VIMVLTVVSVILFLIAFNDSRYTEEAVSINSS-TSII--------------ITLLMTITVIFAYRQITKLDVSQS----- 637 red flour beetle 6_pfamImport 238 IVLAGSFLSIILFFVAMADSKYLDVGLSVNSC-TELT--------------LIVLMSLTVVPLYSQITKLDVNRK----- 297
Q9W4A6 764 -EQS-NLNDILLRISAFGLFTYSVFSIIAGSLKVLES--EPSLLVT---------TTGGVAVFQVILQLLFIADVSRRR- 829 fruit fly CAP34165 433 -AHGeVIDEILLIIGLIGEILYCAVGIDVFITCRRSAdlTVSALPA---------FVFVIRMIQVVVQAAFILTTSRLR- 501 Caenorhabditis ... Q22977 414 -AHGqVVDEILLIVGLAGEIVYCSTGLDLYLNGRLENtpGTSCLTV---------VAFVMRIVQVVVQSVFILVASRLR- 482 Caenorhabditis ... XP_003110541 463 -AHGeVIDEILLIIGLVGELVYCSIGFDMIINGRRTGk-NAPNLAI---------AVFTFRIVQVIIQAMYILIASRLR- 530 Caenorhabditis ... Q22976 453 -AHGeVIDEILLIIGLVGELIYCSIGFDMIVNGNRTGs-HVPNLPI---------AVFTFRIIQVIIQAMYILIASRLR- 520 Caenorhabditis ... PDM84064 480 eSAE-FLDEILLVVGLLGELVFCLGGLLAFVNQNEIH--ALAVLLF---------VSNFLRLIQVTIQSGLIMIGSRLVl 547 Pristionchus pa... XP_002634537 452 nSDQeLLDQILLSIGLVGELIYSVAGLVGLTGEKQWT--NFSFVLL---------FVHIFRLIQVGTQT-FLLHVARSV- 518 Caenorhabditis ... ESN90352 618 fQGL----DYLLFISASGPFAYNVFSLVAAYNK-------PSILVLygmnaigsvVVQVVNILQVYIQIPFCFFAGRV-- 684 Helobdella robusta EFA02328 638 -HVS-LLDDLLLFGCIPAFFLNGIVSIIPAVIS-------QNATSI---------VLIILEVGQVLVQTPLIIDGLRRC- 698 red flour beetle 6_pfamImport 298 -AVS-LLDDLLLFICIPAFFVQTILIITPAWYA-------ENYVGL---------VTAVLQTVQVLIQTPFISDGLRRC- 358
Q9W4A6 830 -VHLPEHDRSKP----GRQIVTFLLICNVAMFAIYTFEAQKVFAN--PVQLEFYGFVPWSIIQRITLPLCIFHRF 897 fruit fly CAP34165 502 -CLSKYSIKYKP----GKEIITFLLVSNVTLFVFHTFEGMKSSFGfsSKAATQY-----NYIIYAVGPLLVFYRF 566 Caenorhabditis briggsae Q22977 483 -SLSASNISNQP----GKQIVTFLVVCNINLFIYHTFETIESNFGfpHKMSSVY-----SALLNISSPLVVFYRF 547 Caenorhabditis elegans XP_003110541 531 -CLSTANTQYQP----GKQTLTFLVIINISLFVYHAFEGMKSTYGfpSIMESKY-----FELLNISSPLVVFYRF 595 Caenorhabditis remanei Q22976 521 -CLSEVNARTQP----GKQTLTFLVLINITLFVYHTFEGMKSTYGfpALMETKY-----FELLNISSPLVVFYRF 585 Caenorhabditis elegans PDM84064 548 dIENPKTIRYKP----GKQVITLLLIINLALFFMNIFEAQKAGVT--DEVVQMYGGRSWALIVRGCSPLTVFYRF 616 Pristionchus pacificus XP_002634537 519 -RMGCEDREAQP----GKQAITFLLTANLAIFFMNLFESEKAGVS--EIIIEYYGKRSWVFLVRSFSPLTIFYRF 586 Caenorhabditis briggsae ESN90352 685 -SAVHPNGKKRPksmhFQAVLVHVSVSNATLWLVNSFATTYNNGSv-YYDSEFFGKDLWNIINSFILPITLFFRF 757 Helobdella robusta EFA02328 699 -SNSKELRREKP----GRELLTFLIVCNVAMWIMQTFEVKSHGLQ--DHKNEFYGEELWTIIGHLCVPLMMFYRF 766 red flour beetle 6_pfamImport 359 -SNTKSLRVQKP----GRELLTFLIVLNVTMWITETFEIKSHTAMdgDPSSRYYGQFLWAVVTHLTFPLTMFYRF 428
Jiyao W et al.(2023). "The conserved domain database in 2023.",