Conserved Protein Domain Family
Caveolin
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pfam01146: Caveolin (this model, PSSM-Id:395911 is obsolete and has been replaced by 460081)
Caveolin
All three known Caveolin forms have the FEDVIAEP caveolin 'signature motif' within their hydrophilic N-terminal domain. Caveolin 2 (Cav-2) is co-localized and co-expressed with Cav-1/VIP21, forms heterodimers with it and needs Cav-1 for proper membrane localization. Cav-3 has greater protein sequence similarity to Cav-1 than to Cav-2. Cellular processes caveolins are involved in include vesicular transport, cholesterol homeostasis, signal transduction, and tumor suppression.
Links
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Statistics
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PSSM-Id: 395911
Aligned: 34 rows
Threshold Bit Score: 166.613
Created: 22-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_007234243  18 LFSRSIEPIltkkeklytpepdrDRDPRDINAHL-KVEFEDIIAEPSSTHSFDSVWIWSHAVFELLKYIFYRLLTTLLAI 96  Mexican tetra
NP_001096351  19 ALTKEIDLV--------------QRDPKKINQEVvQVDFEDVIAEPDGTHSFDGVWKASSTTFTVTKYWCYRVFSAIFGL 84  tropical clawed...
XP_007500210  35 RLKKEIDLV--------------NRDPRHINEDVvKVDFEDVIAEPDGTYSFDGVWKVSYTTYTVSKYWCYRLISTLLGC 100 gray short-tail...
XP_006633332  46 VHTKEIDLV--------------NRDPKHLNDDVvKVDFEDVIAEPEGTHSFDGIWKASFTTFTVTKYWCYRLLTALVGI 111 spotted gar
EFX82628     109 TFTVGLNVL--------------DRDEKHINDTI-NLNFEDVLAEPDVAHGFDPIWRAAFILFTGSRFWIYRLLSAILAL 173 common water flea
KRX73430      95 QMTIGINML--------------DRDEKQLNEHI-KLNFEDILAEPDGYHSWDWVWRGTYHTFNTLRRFIYRFLALLFAV 159 Trichinella sp. T6
PDM72941      86 EMTIGIDMQ--------------MRDEKQINNHV-NIQFDDVFAEPETFHSVDCIWRINHRIFESTRTFFYKVFG-ILSI 149 Pristionchus pa...
EGT60057      94 DQRMGINFV--------------DRDRNNLATNL-DFSFENVFGENKAQHSWEWSYRINHYVYSAFKEIFYKLFQ-WCVL 157 Caenorhabditis ...
Q94051        95 NIAIGVDLV--------------NRDANSMNNHV-QLNFEDIFGEADSQHSWDCVWRLNHTVFTAVRLFIYRLVS-LLAL 158 Caenorhabditis ...
CAP33397      99 HIAIGMDFV--------------NRDHNGLNNHV-QHNFDDIFGEADSQHTWEFMWRLNASVFNWVRLFVYRFFT-ILAL 162 Caenorhabditis ...

XP_007234243  97 PMAFVAGIVFGLLSCVHIWVVMPLVHSCMMALPSVQVVWASLMDMFTGPFFHSFGKSLSSINIKTV 162 Mexican tetra
NP_001096351  85 PLALLWGFLFACLSFCHIWAVVPCVKSYLMEVQCLGQFYALCVRTFCDPIFEAIGKVLSGIKVSLR 150 tropical clawed frog
XP_007500210 101 PLALFWGCIFALISFFHIWTVVPCIKSCLIEMQCISRVFSLFIHTFCHPVFNAMGQMCSSIKLVFR 166 gray short-tailed opossum
XP_006633332 112 PLALIWGLFFAILSFLHIWAVVPCVKSYLIEIQCVSRVYSICIHTFCDPLFEAMGKVFSGVRVSMT 177 spotted gar
EFX82628     174 PLALVWGITFSLITFFSVWLATPLLRIMDVFLFYIRRVWVALVQTTLEPVANAVGGCFSNVKLTHN 239 common water flea
KRX73430     160 PCAIVWAMLFALLTSINVWILTPLAIAISIPAVWLAKTWNFIIRSLLDPFFKSCGLMRAAHSESpt 225 Trichinella sp. T6
PDM72941     150 PIVFIFAILFAFASAVNNFLVMPLAALFTIPLTWIAKTWTFLVSNIFDPVANSIGLCFSKINVRKy 215 Pristionchus pacificus
EGT60057     158 PFTVFFAIFVALFVTLYSWILLPLGKLLIIPGTVVAAVWSWLIHAIFDPIFSSLGLLFSNFNIRKy 223 Caenorhabditis brenneri
Q94051       159 PFTIIFAIFFGLLASINVFIIVPLGKLLSIPGTLLAKLWNWLIHAIFDPIASAVGLIFSNFNIRKy 224 Caenorhabditis elegans
CAP33397     163 PFTLLFAIFFGFFAAVNVFVIVPFGKLISIPGNLLAKLWNWLVHAVFDPVASAVGLIFSNFNIRKy 228 Caenorhabditis briggsae
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