5A63


Conserved Protein Domain Family
Presenilin

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pfam01080: Presenilin (this model, PSSM-Id:395857 is obsolete and has been replaced by 460052)
Presenilin
Mutations in presenilin-1 are a major cause of early onset Alzheimer's disease. It has been found that presenilin-1 binds to beta-catenin in-vivo. This family also contains SPE proteins from C.elegans.
Statistics
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PSSM-Id: 395857
Aligned: 56 rows
Threshold Bit Score: 259.826
Created: 22-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5A63_B        76 KYGAKHVIMLFVPVTLCMVVVVATIKSVSF-------YT--RKD-----GQ-LIYTPFTEDTETVGQRALHSILNAAIMI 140
XP_001299078  12 eIYSKRIYKIAVPVILTLVIDVWLTRTLEEkfdntalSTsfASVv---------------SQSSGGVSTAVAIYIAIGFI 76  Trichomonas vag...
XP_001326572  12 eFYARKVAKIAVPVVLTLILDAVCIRFIERthgsaelNRnfVDTm---------------SRNDSGISVTASIWSAVGII 76  Trichomonas vag...
EPB83259      49 QFYVEQLTLLFYPLIVTFALTCWIEITLNI-------DSsqISN------PlMVYDEL--PSDSVGTRLGGSVLNAIIVV 113 Mucor circinell...
7_pfamImport   1 LNRSSQLKWTLFSVIVNMLLTLSVWIGV---------YGmeVNS-----ELsRLYFLDTASNSTTGNPVLDGAINGMFTI 66 
Q01608        11 LVRSSQLRWTLFSVIANMSLTLSIWIGV---------YNmeVNS-----ELsKTYFLDPSFEQTTGNLLLDGFINGVGTI 76  Caenorhabditis ...
EFO85358       9 FRRSSQLQWTLFSVIVNMSLTLSIWIGI---------YQmqVNS-----ELsKLYFLDDSFERTTGNTTLDGLINGFATI 74  Caenorhabditis ...
CAP30997       9 LRRSSQLQWTLFSVVVNMSLTLAIWIGI---------YHmeVNS-----ELsKMYFLDDSFNWTTGNPALDGLINGFCTI 74  Caenorhabditis ...
XP_015632905  27 dslGEDITRIVTPVSTCMLLVVLLVSLL----------SspSSPspftaAFsAAAG-----PGGGGDDITTALITAVTFV 91  Japanese rice
EFH55498      12 dslGEELIAILTPVSICMFTVVLLVCILN--------SDpsSSSasfssIAtAAYAES--DSDSSWDKFVGALLNSVVFV 81  Arabidopsis lyr...
5A63_B       141 SVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFIYLGEVFKTY-------NVAVDYITVALLIWNFG-VVGMIS 212
XP_001299078  77 VAIALVTGLLLLLYWFNCVKCIYVWMVVAVSLLLSYYVYLAVGKIPSLY-------NIPIDYIAVVIFLLNGV-VVGGMS 148 Trichomonas vag...
XP_001326572  77 FMIIVVTAILLTLYYFGCMKIIFGWLILAVSLLLSMYFLVGFGTYPSIV-------NIPVDYLSLAVFLLNLV-VVGNMS 148 Trichomonas vag...
EPB83259     114 CGITLMTFMFVLCFKYRLYKFLFFWLGLSVLSILGVTASALWIEMLNVY-------NMPMDYLTMLFCTWNVA-VVGVVA 185 Mucor circinell...
7_pfamImport  67 VVLGIVSFVMLGFVLYDFQNLVKTWLIFSCLLILFGVSGQTFYDLFSQLvdqetenGRNLTLVLTILPTLVYG-LAGIVA 145
Q01608        77 LVLGCVSFIMLAFVLFDFRRIVKAWLTLSCLLILFGVSAQTLHDMFSQVfdqddnnQYYMTIVLIVVPTVVYG-FGGIYA 155 Caenorhabditis ...
EFO85358      75 LVLGCVSFVMLAFVLYDFQRVVKAWLTLSCMLILFGVSGQTLYDLFTQIldqndenQYILTVALTVIPTTIYG-VLGIYA 153 Caenorhabditis ...
CAP30997      75 LVLGCVSFVMLAFVLYDFRRIVKSWLTFSCLLILFGVSGQTIYDLFSQIfdqndenQFILTVALTVIPTVVYG-CLGIYA 153 Caenorhabditis ...
XP_015632905  92 VAVTAATFLLAFLFYLRCTPCLRAYLGFSSLSVLLLLGGHVALLLLSRL-------RLPLDAASFALLLPNAAaALALAA 164 Japanese rice
EFH55498      82 AAITVATFVLVLLFYLRCVKFLKFYMGFSAFIVLGNLGGEILVLLIDRF-------RFPIDSITFLILLFNFS-VVGVFA 153 Arabidopsis lyr...
5A63_B       213 IHW-KGPLRLQQAYLIMISALMALVFIKYLPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSST 291
XP_001299078 149 IFW-RAPPIVTQAFMIWISVMTACVFLT-LPDWTVWILLVLLIIWDCCVVLCPNGLLHLLIKKSQERGDAI-PALVYSSA 225 Trichomonas vag...
XP_001326572 149 IFW-RAPQRITQAFLVLISILTSIVFRY-LPDWTVWILLVLLIIYDACVVLCPNGLLILLLKKSEERGDAI-PALLYSAA 225 Trichomonas vag...
EPB83259     186 IFW-KSPLWVQQVYLVLVSAATSISMLR-MPPWTTWTVLIAVAIYDLFAVLCPAGPLRLLITMAEERQENI-PALVYSAG 262 Mucor circinell...
7_pfamImport 146 FLA-NGSLLLHQCFVVSNCSLIAVFYLRAFPRHTTWFVLFIVLFWDLFAVLTPMGPLKRVQEKASDYSNNILKFLMFAAD 224
Q01608       156 FFS-NSSLILHQIFVVTNCSLISVFYLRVFPSKTTWFVLWIVLFWDLFAVLAPMGPLKKVQEKASDYSKCVLNLIMFSAN 234 Caenorhabditis ...
EFO85358     154 FFA-NGSLALHQFFVISNCSLISVFYLRAFPRYTTWFVLWMVLFWDLFAVLAPMGPLKKVQEKASDYSNNILKFLMFAAE 232 Caenorhabditis ...
CAP30997     154 FLA-NGSLLLHQFFVVSNCSLIAVFYLRAFPKHTTWFVLWTVLFWDLFAVLAPMGPLKKVQEKASDYSNNILKILMFAAE 232 Caenorhabditis ...
XP_015632905 165 LSPaSVPIALHQAALVAIAVLTAFWFTL-LPEWTTWALLVAMAVYDLAAVLLPGGPLRLLLELAIERNEEI-PALVYEAR 242 Japanese rice
EFH55498     154 VFMsKFSILITQGYLVWIGVLVAYFFTL-LPEWTTWVLLVALALYDIAAVLLPVGPLRLLVEMAISRDEDI-PALVYEAR 231 Arabidopsis lyr...
5A63_B       292 MVWL-----------VNMAEGDPEAQRRVSKNSKY-NAESTERESQDTVAENDDGGFSEEW------------------- 340
XP_001299078 226 AFFWkea-----ddgEEQNEEGEDHENLDNYDEEYdSASEDESTDPDSSASSDDALPINPDefvglsnnped-----qpp 295 Trichomonas vag...
XP_001326572 226 AWEEadpekgnqnneEGDGNEGNQEDPAEQADNQDnNEEEEEEEEAEnnq------------------------------ 275 Trichomonas vag...
EPB83259     263 MASFdteddfiggyrTQESNRASKNHKKWLPFTNAnKGYRPIHnne---------------------------------- 308 Mucor circinell...
7_pfamImport 225 DNRQsagadr---aeevnEGDGTIRRGVKQLIAMYsKQEAQDEEFAQKIRQRRSAWNPDSGlteqsplvetepspsvpte 301
Q01608       235 EKRLtagsnq---eetneGEESTIRRTVKQTIEYYtKREAQDDEFYQKIRQRRAAINPDSVptehsplveaep---spie 308 Caenorhabditis ...
EFO85358     233 DKREtagidatedssENLNDERKLRKDVKQLIELYsKKEAQDDEFLRKIRQRRTAINPDSAltetspvhteps--daliq 310 Caenorhabditis ...
CAP30997     233 DKREsagmdmaqdsqENLNDERKLRKDVKELIQLYsKQDEKDDEFLQKIRQRRNAINPDSGstahspmvttep---spiv 309 Caenorhabditis ...
XP_015632905 243 PVDPrhghnwrlwreRTQSGAELDANSTVEVLGEVlGTNLGASSAGNLGVSAIRSDERVGLagdarnlrlgt----smpn 318 Japanese rice
EFH55498     232 PVIRndsr----lvqRRVWRERRSNDAENHANRNEvRAVRSEEveeeh-------------------------------- 275 Arabidopsis lyr...
5A63_B       341 -------EAQRDSHLGP-HRSTPES------RAAVQELSSSILAGED----P---------------------------E 375
XP_001299078 296 pqpkpeqQPESELAQPAgEPTKPKK------KRPNQDNQHGDPENPDkrkkKsgsaks---------------------- 347 Trichomonas vag...
XP_001326572 276 ----pqeNANGEAQNGNqNNNKKKK------NMSKRDNE----------------------------------------- 304 Trichomonas vag...
EPB83259     309 ----ldeNATLSIALSTlEQSRDVE------RRNSNEAGQDEDEEEDel------------------------------- 347 Mucor circinell...
7_pfamImport 302 hqqeekeDKQMDSESSSeSCSESAS-------IASGDSNADDKEKEEeddeYqssnietaeecdm--etwqqlvneanaK 372
Q01608       309 lkeknstEELSDDESDTsETSSGSS------NLSSSDSSTT----------Vstsdistaeecd----qkewddlvsnsL 368 Caenorhabditis ...
EFO85358     311 lksknsdEEHTDDESDTtESSTTTS---------SSD--------------VttsevstaeevapeewnelmeqqekqaE 367 Caenorhabditis ...
CAP30997     310 lkeknsdEELFDNESDTtESSSESS--------TSSESV------------Fsssdvstaaeca---peewnelihqqnE 366 Caenorhabditis ...
XP_015632905 319 lssdsasAQVEVLPASPeISVSVPEmrvpliQPRPERTRDEEDDEDGiglsSs--------------------------- 371 Japanese rice
EFH55498     276 ---vgssERAEISVPLIdRRPEQAE------NSETF--------LEGiglgSs--------------------------- 311 Arabidopsis lyr...
5A63_B       376 E------------------------------R---GVKLGLGDFIFYSVLVGKASatASGDWNTTIACFVAILIGLCLTL 422
XP_001299078 348 ------------------------------tptseGVKLGLGDFIFYGILVTRAA--R-VGWDIAILDILAVMDGLALTL 394 Trichomonas vag...
XP_001326572 305 -----------------------------------GIKLGLGDFVFYGILVSRAA--R-IGWDITILCIFAVILGLSLTL 346 Trichomonas vag...
EPB83259     348 ----------------------------------nAIKLGLGDFIFYSVLVGKAA--K-TDSVTLCLCIIAILTGLSLTI 390 Mucor circinell...
7_pfamImport 373 Qgdnksnlta-----------------adalndgeTVRLGFGDFVFYSLLIGQAA--ASGCPIAVVFAAAGILFGLLVTL 433
Q01608       369 Pnndkrpata-----------------adalndgeVLRLGFGDFVFYSLLIGQAA--ASGCPFAVISAALGILFGLVVTL 429 Caenorhabditis ...
EFO85358     368 Fdqryvpvta-----------------adalndgeTVRLGFGDFVFYSLLIGQTA--TGGSALAVACSALGILFGLVATL 428 Caenorhabditis ...
CAP30997     367 FdqndatvtaadalndgvksknsgrlfseicRfpeTVRLGFGDFVFYSLLIGQAA--TGGCPISVGFAAFGILFGLIATL 444 Caenorhabditis ...
XP_015632905 372 ----------------------------------gAIKLGLGDFIFYSVLVGRAA--M-YDYMTVYACYLAIIAGLGITL 414 Japanese rice
EFH55498     312 ----------------------------------gAIKLGLGDFIFYSVLVGRAA--M-YDLMTVYACYLAIIAGLGITL 354 Arabidopsis lyr...
5A63_B       423 LLLAIFKKALPALPISITFGLVFYFATDYLVQPFM 457
XP_001299078 395 ICLAYFERPLPALPFSLALGIIFYLIGAYTFRGFs 429 Trichomonas vaginalis G3
XP_001326572 347 VCLAVWERPLPALPFSLALGIVFFIIGAMTFRQFC 381 Trichomonas vaginalis G3
EPB83259     391 LILTLNRKALPALPISILLGCITYATAYYMTSPMi 425 Mucor circinelloides f. circinelloides 1006PhL
7_pfamImport 434 TVLSTEESTTPALPVPVLCGTFCYFTSKFVWENL- 467
Q01608       430 TVFSTEESTTPALPLPVICGTFCYFSSMFFWEQLY 464 Caenorhabditis elegans
EFO85358     429 TVFSSGESTTPALPLPVICGTFCYFISKFVVDQVY 463 Caenorhabditis remanei
CAP30997     445 TVLSSEESTTPALPLPVICGTFCYFVSRFLVDSiq 479 Caenorhabditis briggsae
XP_015632905 415 LLLAFYRKALPALPVSIALGVVFYVLTRTLLETFV 449 Japanese rice
EFH55498     355 MLLSVYQKALPALPVSIMLGVVFYFLARLLLEVFV 389 Arabidopsis lyrata subsp. lyrata
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