5SY7


Conserved Protein Domain Family
bHLH-PAS_NPAS3_PASD6
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cd19732: bHLH-PAS_NPAS3_PASD6 
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basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 3 (NPAS3) and similar proteins
NPAS3, also termed neuronal PAS3, or Basic-helix-loop-helix-PAS protein MOP6, or Class E basic helix-loop-helix protein 12 (bHLHe12), or member of PAS protein 6, or PAS domain-containing protein 6 (PASD6), is a bHLH-PAS brain-enriched transcription factor that is involved in central nervous system development and neurogenesis. It is a replicated genetic risk factor for psychiatric disorders. Human chromosomal rearrangements that affect NPAS3 normal expression are associated with schizophrenia and mental retardation.
Links
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Statistics
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PSSM-Id: 381575
Aligned: 8 rows
Threshold Bit Score: 145.914
Created: 28-Jun-2018
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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DNA bindingdimer interface
Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:The N-terminal basic region of bHLH mediates high-affinity DNA-binding to specific hexanucleotide sequences
  • Structure:5SY7; Mus musculus NPAS3-ARNT complex with HRE DNA, contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1              # ###   # ##   #                    ##                                  
5SY7_B         1 MIQALRKEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLKMRDFANQGDPPWNLRMEGPPPN 78   house mouse
Q8IXF0        47 NLQALRKEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLKMRDFANQGDPPWNLRMEGPPPN 124  human
OCT66373      70 SLQALRKEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLKMRDFANQGDPPWNLRMEGPPPN 147  African clawed frog
AGQ45474      47 NLQALRKEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLKMRDFANQGDPPWNLRMEGPPPN 124  chicken
XP_007891569  65 SLQALRKEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLKMRDFANLGDPPWNLRMEGPPPN 142  elephant shark
PIK62730      13 RLLAIRKERSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLSISYLRMRDFALQGDPVWHQSQPSSYGS 90   Japanese sea cuc...
XP_014350190  17 RLQALRKEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLKMRDFANQGDPPWNLRMEGPPPN 94   coelacanth
ESO12518       5 RILELRKEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLKLRDFSSHGDPPWNRDEQNIVKT 82   Helobdella robusta

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