4Z4P,5F6K


Conserved Protein Domain Family
SET_KMT2C_2D
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cd19171: SET_KMT2C_2D 
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins
This family includes KMT2C and KMT2D. Both, KMT2C (also termed HALR or MLL3) and KMT2D (also termed ALR or MLL2), act as histone methyltransferases that methylate 'Lys-4' of histone H3 (H3K4me). They are subunits of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation.
Links
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Statistics
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PSSM-Id: 380948
Aligned: 16 rows
Threshold Bit Score: 304.352
Created: 7-Jun-2018
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
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Conserved site includes 29 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:5F6K: Homo sapiens mixed lineage leukaemia MLL3 SET domain in complex with peptide ARTKQTARK and SAH, contacts at 4
    - View structure with Cn3D
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                               ####                #          #  #         #####     #   
4Z4P_A          6 KSSQYRRLRTEWKNNVYLARSrIQGLGLYAAKDLEKHTMVIEYiGTIIRNEVANRREKIYEEqNRGIYMFRINnEHVIDA 85   human
OWF43010     2500 KSQQYRRLKTEWKNNVYLGRSrIQGLGLFAAKDTEKHTMVIEYiGDLIRNEVANRREVIYEEqNRGVYMFRIDnEVVVDA 2579 Yesso scallop
CAA15944     2269 KSSQYKKMKQEWRNNVYLARSkIQGLGLYAARDIEKHTMIIEYiGEVIRTEVSEIREKQYESkNRGIYMFRLDeDRVVDA 2348 fruit fly
CCD79516     1276 KSQQYRRLRWDWKTNVVLARSrIQGLGLYAARDISKSTFIIEYlGEVIRNEVANRRERLYESqNRGIYMFRVDdDWIVDA 1355 Schistosoma m...
OQR73767      902 KASQYRRMKTEWRSNVYLARSkIQGLGLYAARDIEKHTMVIEYiGQVIRNEVANAREKQYESqNRGIYMFRLDeNRVIDA 981  Tropilaelaps ...
EFX80495      775 KSSQYKKMKQEWRHNIYLARSkIQGLGLYAARDIEKHTMVIEYiGEMIRAELAECREKRYEAaNRGIYMFRLDeQRVIDA 854  common water ...
PIK39610      705 KSSQYKKLKTDWKQCVYLAKSnIQGLGMYAATDIEKHTMVIEYvGTLIRNETSNLREKNYNAaNRGIYMFRIDnDTVCDA 784  Japanese sea ...
ELT96958      691 KSQQYRRLKTEWRINVYLRRSnVQGLGLFASRDLERHTMVIEYiGELIRSEVAEARERVYDSqNRGVYMFRIDdNTVVDA 770  Capitella teleta
BAE06306      436 KSSQYRRMKQEWRSNVYLARSrIQGLGLFASRDIEPGTMVIEYiGDIIRSEVAEKREKNYEAaNRGVYMFRLDsDYIVDA 515  Ciona intesti...
XP_023929977 2459 KSQQYRRMKTEWRSLVYLARSrIQGLGLYAARDTEKHTMVIEYiGELIRNETAEMREKIYEAsNRGIYMFRINdDTVVDA 2538 Lingula anatina

Feature 1                #####       # #                         # ###          ####        #
4Z4P_A         86 TLtGGPARYINHSCaPNCVAEVVTFdk-eDKIIIISSRRIPkGEELTYDYQFDFEdd-qhEIPCHCGAWNCRKWM 158  human
OWF43010     2580 TMaGGPARYINHSCnPNCVAEVVAFdk-eSKIIIITNRKLAkGEELTYDYKFDFEde-qhKIPCCCGAPNCRKWM 2652 Yesso scallop
CAA15944     2349 TLsGGLARYINHSCnPNCVTEIVEVdr-dVRIIIFAKRKIYrGEELSYDYKFDIEde-shKIPCACGAPNCRKWM 2421 fruit fly
CCD79516     1356 TMsGGLARYINHSCdPNCTAEILHCdn-sNHIVIIASKNIEkGDELTYDYKFDLEedrwdRIPCLCGSINCRKWM 1429 Schistosoma mansoni
OQR73767      982 TLtGGLARYVNHSCnPNCVTEVVDVdk-dQKILIIAKRRIArGEELSYDYKFDFEdd-qhKIACLCGAPNCKKWM 1054 Tropilaelaps merce...
EFX80495      855 TLcGGLARYINHSCgPNCVAEAVEVer-dLRIIIFASRRIArGEELSYDYKFDIEdd--hKIPCLCGAASCRKWM 926  common water flea
PIK39610      785 TIsGNAARYINHSCdPNCVAEVVTFgpdtKKIIIFSNRKLMkGEELTYDYKFDIEddrqkKIPCTCKAHNCRKWM 859  Japanese sea cucumber
ELT96958      771 TMtGGPARYINHSCaPNCVAEVVPFek-dSKIIIIARRRIArGEELTYDYKFDFEdd-qhKIPCLCGAPNCRKWM 843  Capitella teleta
BAE06306      516 TVtGGPARYINHSCnPNCVAEVVNFek-eKKIMIISNRHILsGEELNYDYKFDFEde-gnKIPCLCGAINCRKWM 588  Ciona intestinalis
XP_023929977 2539 TMsGGLARYVNHSCnPNCVAEVVPFek-eSKIIIIAKRRIAtGEELTYDYKFDFEde-qhKIPCCCGAPNCRKWM 2611 Lingula anatina

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