3F9W,1ZKK,2BQZ,4IJ8,5W1Y,5HQ2,1ZKK,5TEG,5T5G,3F9Z,5V2N,4LDG


Conserved Protein Domain Family
SET_SETD8
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cd10528: SET_SETD8 
SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins
SETD8 (EC 2.1.1.43; also termed N-lysine methyltransferase KMT5A, H4-K20-HMTase KMT5A, lysine N-methyltransferase 5A, lysine-specific methylase 5A, PR/SET domain-containing protein 07, PR-Set7 or PR/SET07) is a nucleosomal histone-lysine N-methyltransferase that specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). It plays a central role in the silencing of euchromatic genes.
Links
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Statistics
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PSSM-Id: 380926
Aligned: 41 rows
Threshold Bit Score: 182.006
Created: 28-Apr-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
Conserved site includes 15 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:3F9W; Homo sapiens SETD8 binds histone4 Lys20 and the Adomet derivitive, AdoHyc, contacts at 4A.
    - View structure with Cn3D
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                       ###                #                             
3F9W_A        14 SEERKRIDELIESGke--eGMKIDLIDG--KGRGVIATk-qFSRGDFVVEYHGDLIEI---TDAKKREALYAQDps---- 81   human
CCD76627     256 RERENNFLNALKNNie--tGMKIIQTEE--KGRGIIATr-tFYEGEFVVEYAGDLISE---KLAKQREAVYKQNpe---- 323  Schistosoma ma...
XP_002114992  55 NAEEAFMIQYILTNke--dGIQMIYTEG--KGRGIVTTk-pFKKGDFLCEYAGELISR---KEALQREVSYGKDpn---- 122  Trichoplax adh...
EGD78327     207 KEQQLQEIQNMIREerdspHLDIVDIEG--KGKGVLARr-tFEKGEYVCEYAGDLITK---PEAAEREQRYLTEareqhl 280  Salpingoeca ro...
XP_003387132  69 EEKTSEIIRKLEHKie--dGLKVIETDG--KGRGVVATr-tFHKDELICEYSGELISY---REAVQREQEYSKDsg---- 136  Amphimedon que...
KJE97240     225 RLLLANIQQAIRIGne--dHLEVYQTPT--IGFGIKATr-dYERSDYVCEYAGDLIDI---SEAKRRNEEYMKDes---- 292  Capsaspora owc...
CBY20626     200 DEKDDLWRDLVRSDcq--eGLEIRNCPI--KQRGIYSTr-dFRKGDFVVEYRGTFFYPeniEESYAQESKYYEDpe---- 270  Oikopleura dioica
KTG02764     410 VESDPWIITTIQNQkw--tGLALKDFGT--KGQGVVATk-aFAMGSIVCDYHGKVITG---AEGRKLVESIKGD------ 475  common carp
EKC22399     791 DVSHEDLLRRVKTQew--pNLVVREVQE--KGTGVFTGelaFNRGEVVCDYHGDDIPA---KEGERRLQTYGDYqt---- 859  Pacific oyster
PIO24608      27 VDHTEEIERLVESQdw--kGLAIVEDRAgnTGETVITTl-pFQKGDFVCDCHGPVVSH---ERGEEIMNSIAPGe----- 95   bullfrog

Feature 1            #####                             #####                                     
3F9W_A        82 --tGCYMYYFQYL--SKTYCVDATREtn-------rLGRLINHSKc-GNCQTKLHDId----GVPHLILIASRDIAaGEE 145  human
CCD76627     324 --iGSYMFFFVHA--GQRYCVDATKEtp-------rLGRLINHSRlkPNCIVKVIPId----GIPRLALFARKSISpGEE 388  Schistosoma ma...
XP_002114992 123 --iGNYMYFFSYK--GSDFCVDATKEtd-------rLGRLVNHSRknYNSISRLIPIn----GNPHLVLIAYRDIGiGEE 187  Trichoplax adh...
EGD78327     281 demMCYMYFLRHR--GKVWCVDATHSk--------rIGRLINHSRssFNLRTKLFEVd----GTPHLGLVATREISkGEE 346  Salpingoeca ro...
XP_003387132 137 --iGCYMYYFEFQ--SKKLCVDATTDnk-------rMGRLVNHSKtkPNVITKLIPVe----DHPYLCLMAARTVSpGEE 201  Amphimedon que...
KJE97240     293 --iGCYMYFFQHK--ETRWCVDATHSt--------rKGRLINHSKtdQNLLTRILTVd----DKPRLVFFATKHISrGDA 356  Capsaspora owc...
CBY20626     271 --tGSYMYWFDYK--GKKYCIDATAEsp-------fYGRLLNHSCkvPNCATKPLDMqd-piDPVRLIIYAKEDIPsGTE 338  Oikopleura dioica
KTG02764     476 ---MAYLFFFHAA--GRDLCVDAETFpcechptentMGRRINHSSkrANLRPVHCVMnfpegQRDVILFQAKRDIHiCEE 550  common carp
EKC22399     860 -dgNYFLFYTNAK--GKKRCIDAANPcpchp-niktKGRLINHAAgnPNLKSTRLVVn----GEEHVFLVAQKFIApFVE 931  Pacific oyster
PIO24608      96 ---MCYLYFFKDKkhQRRLCIDAQNVpcpchpglstYGRKINHSKrkPNLKPEVRYLkn--gTTPVILLIAKEDIDvGTE 170  bullfrog

Feature 1            #   
3F9W_A       146 LLFDYGDR 153  human
CCD76627     389 LLYDYGDR 396  Schistosoma mansoni
XP_002114992 188 LLYDYGDH 195  Trichoplax adhaerens
EGD78327     347 LLYDYGER 354  Salpingoeca rosetta
XP_003387132 202 LVYDYGER 209  Amphimedon queenslandica
KJE97240     357 LWYDYGER 364  Capsaspora owczarzaki ATCC 30864
CBY20626     339 LLYDYGDR 346  Oikopleura dioica
KTG02764     551 LLFDYGVK 558  common carp
EKC22399     932 LTYDYSVR 939  Pacific oyster
PIO24608     171 LTFDYGVT 178  bullfrog

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