2MDR


Conserved Protein Domain Family
DSRM_DRADA_rpt3
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cd19915: DSRM_DRADA_rpt3 
third double-stranded RNA binding motif of double-stranded RNA-specific adenosine deaminase (DRADA) and similar proteins
DRADA (EC 3.5.4.37; also known as 136 kDa double-stranded RNA-binding protein (p136), interferon-inducible protein 4 (IFI-4), K88DSRBP, ADAR1, G1P1, or ADAR) catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA), referred to as A-to-I RNA editing. Vertebrate DRADA contains three double-stranded RNA binding motifs (DSRMs). This model describes the third motif. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure.
Links
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Statistics
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PSSM-Id: 380744
Aligned: 6 rows
Threshold Bit Score: 124.284
Created: 24-Oct-2018
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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putative RNA
Conserved site includes 20 residues -Click on image for an interactive view with Cn3D
Feature 1:putative RNA binding site [nucleic acid binding site]
Evidence:
  • Comment:Based on structure evidence that Homo sapiens TARBP2 (5N8L) binds siRNA.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         # ##  ##  ##     ##          #### #                ####  ##             
2MDR_A         37 TNPVGGLLEYARSH-GFAAEFKLVDQSGPPHEPKFVYQAKVGGRWFPAVCAHSKKQGKQEAADAALRVLIGE 107  human
AAF69672      867 NNAVSGLLELRPVLeASLLSIRLVGQSGPSHEPKFTYQAKLGGRWFPAVCASNKKQGKQEAADAALRVLIGE 938  zebrafish
CAJ47419      373 VNPVSGLLEYARSN-GFAAEFKLIDQTGPPHDPKFVYQAKVGGRWFPAVTAHSKKQGKQEAADAALRVLIGE 443  chicken
XP_014344140  675 KNAISGLLEYARSK-GFAADLKLIDESGPPHDPKFTYQAKVGGRWFPAVSANNKKQAKQEAADAALRVLIGE 745  coelacanth
P55265        725 TNPVGGLLEYARSH-GFAAEFKLVDQSGPPHEPKFVYQAKVGGRWFPAVCAHSKKQGKQEAADAALRVLIGE 795  human
OCT66662      432 ANPVSGLLEYARAK-GFAAEFKMVNQTGPPHDPKFVFQAKVGGRWFPAVSASNKKQAKAEAADAALRVLIGE 502  African clawed frog

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