4XWH,2VC9


Conserved Protein Domain Family
NAGLU
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pfam05089: NAGLU (this model, PSSM-Id:377453 is obsolete and has been replaced by 461545)
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Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain
Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This central domain has a tim barrel fold.
Links
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Statistics
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PSSM-Id: 377453
Aligned: 158 rows
Threshold Bit Score: 342.941
Created: 5-May-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4XWH_A          108 YYQNVCTQSYSFVWWDWARWEREIDWMALNGINLALAWSGQEAIWQRVYLA-LGLTQAEINEFFTGPAFLAWGRMGNLHT 186  human
IGS:B005_5065    87 YHLNFCTTGYTAAYWNWADWEREIDWMALHGVTTPLTLTGHEAVLYDTYVR-LGMDEERVREFIGGPGYLPWQYMGNLDH 165  Nocardiopsi...
jgi:Bcav_0303   121 YDLNVVTTGYTAPYWDWARWEREIDWMALHGITTPLMVVGHETVLLRTFTA-LGLDPGDVVAWLGSAAHLPWTLMGSTSS 199  Beutenbergi...
jgi:Bacsa_2394  117 YDFNYCTYSYTMAFWDWARWEKEIDWMALHGINLPLAAVGQECVWRNMLAK-LGYTKEETNRFIAGPAFLAWWAMNNLEG 195  Bacteroides...
EGQ13735        134 YDFNYCTFSYSMVFWNWDRWQQEIDWMALHGVNMPLAIVGEEVVWRNMLLR-LGYTRDEVNRFIAGPAFLAWWAMNNLEG 212  Prevotella ...
jcvi:PRU_1852   113 YDFNYCTFSYSMAFWDWKRWEKEIDWMALHGINMPLAIVGEECVWRNMLLK-LGYTEKEVGEFIAGPAFLAWWEMNNLEG 191  Prevotella ...
CCX48275        158 YYLNYCTFSYSMPFWNEARWQQEVDWMALHGVNMPLMLVGSAAVWRTTLRD-IGYPENKINSFVAGPAYQAWWLMNNLQG 236  Bacteroides...
CCY34524        132 YYLNYCTFSYSMAFWDWERWEKELDWMALHGINLCLAAVGSDALWLNVLRR-LGYSESDAAEFIAGPAFQAWWLMNNLEG 210  Alistipes s...
CDA42333        134 YYLNYCTFSYSMSVWTWDRWQKEIDWMALHGINMPLQIVGLDVVWRNLLVNdLGYTKDEANAFIAGPCFQAWWGMNNLEG 213  Prevotella ...
CDE87068         80 YYLNYCTFSYSMSTWTWERWQQEIDWMALHGINMPLQIVGLDVVWYNLLTKdLGYTAAEANQFVAGPCFQAWWGMNNLEG 159  Prevotella ...

4XWH_A          187 WDGPLPPSWHIKQLYLQHRVLDQMRSFGMTPVLPAFAGHVPEAVTRVFPQVNVTKMGSWGHFNCSYscsfLLAPEDPIFP 266  human
IGS:B005_5065   166 FAGPMPRSWIEGHRELGRRVLERQRALGMTPVLPGFTGHVPPSLAPGRTGSRT-----WQG-LVTH----VLVPTDPLYT 235  Nocardiopsi...
jgi:Bcav_0303   200 FGGPLPDSWFERRAELGRRILERQRELGMRAVLPAFGGHVPDGLG---AGARTH----WQG-FSTA----LLGPDDDAFA 267  Beutenbergi...
jgi:Bacsa_2394  196 WGGPNPDSWYTQQEALQKKILKRMREYGIEPVLPGYSGMVPHDAHQKLGL-NVTEPELWNGFTRPA----FLMPTDKRFA 270  Bacteroides...
EGQ13735        213 WGGPLPDSWYRQQEALQKRILQRERELGMEPVLPGYCGMMPHDAKQKLGL-DVTPGGTWNGYVRPA----NLSATDPRFD 287  Prevotella ...
jcvi:PRU_1852   192 WGGPLPTSWYARQEKLQKQILARMKQLGMHPVLPGYCGMVPHDAKEKLGL-NVADAGLWNGFQRPA----NLLPTDARFS 266  Prevotella ...
CCX48275        237 WGGPQSSHMYDRDARLGRFVADAMRQMDMQPVLPGYSGMVPADADTQLGL-HTADPGLWLGYVRPA----FLLPTDSAFA 311  Bacteroides...
CCY34524        211 WGGPNPDSWYKRNIGLQNRILQRMRELGIEPVLPGYSGLLPHDAAERLGL-NVSDPGLWQGYHRPA----FLQPEDRNFQ 285  Alistipes s...
CDA42333        214 WGGPNPDWWYTRQEGLAKKILARERELGMQPVLPGYAGMVPSNIESKKGY-KANNQGNWCNFVRPY----ILDPNSTAFT 288  Prevotella ...
CDE87068        160 WGGPNPEWWYKRQAALAQNILKRQRELGMQPVLPGYSGMVPSDIGKK-GF-TANNQGKWCTFTRPF----ILDPNGRDFA 233  Prevotella ...

4XWH_A          267 IIGSLFLRELIKEFGTDXIYGADTFNEMQPPSSEPSYLAAATTAVYEAMTAVDTEAVWLLQGWL-FQHQPQFWGPAQIRA 345  human
IGS:B005_5065   236 TLCAEIVETQKELFDTDHQYAIDPFIEMIPVDSDPGFPGLVARATIEGLTRADPRAVWFLQTWP-FSYQSDFWSPERVEA 314  Nocardiopsi...
jgi:Bcav_0303   268 VVAAEFARQQRELFGTDHLYAADPFIESVPPSGEPEDLAAFAAATYAGMSAADPEATWVMQAWP-FHYHRRFWTAERIAA 346  Beutenbergi...
jgi:Bacsa_2394  271 EIAALYYEEQEKLFGKANYYSMDPFHELE--NAGEVDFDAAGKAVMDAMKQVNPKAVWVVQGWT-E---------NPRPE 338  Bacteroides...
EGQ13735        288 EIADLYYREQTRLYGKSHYYSMDPFHETS--DDVYIDYAQAGRKLMAAMKRENPKANWVIQGWT-E---------NPRPA 355  Prevotella ...
jcvi:PRU_1852   267 EIATLYYNELTKLFGKADYYSMDPFHESN--DDPNIDYAKAGQAMMQAMKRVNPKAVWVIQGWT-E---------NPREA 334  Prevotella ...
CCX48275        312 AIARTYYSAQQSILGRASCYAMDPFHEDG--STDGVDLPAAGNALLSAAQLASPGARWVIQAWQ-N---------NPRAA 379  Bacteroides...
CCY34524        286 TIAAIYYEEQEKLFGKARFYSMDPFHEGG--RTAGVNLDSAGTAINSAMQHHSPGAKWVVQAWG-A---------NPRPA 353  Alistipes s...
CDA42333        289 EISALYYKRLEELMGTSEYYSMDPFHEGA--NTDGIDVASAYSKIADAMYKANSNGKWVIQFWQwS---------GAQYN 357  Prevotella ...
CDE87068        234 TISDKYYKRLEELMGTSVYYSMDPFHEGA--NTSGIDVPAAYSKIAEAMTKANPESKWVIQFWQwS---------GAQYH 302  Prevotella ...

4XWH_A          346 VLGAVpRGRLLVLDLFAESQP-------VYTRTASFQGQPFIWCMLHNFGGNHGLFGALEAVNGGPEAARLf---pNST- 414  human
IGS:B005_5065   315 FLDAIpDDHLHLLDLWAEYDP-------QWSRFHAFGGTPWTWCALLNFGGRTDPMADLQGAADRIGAAKDsa------- 380  Nocardiopsi...
jgi:Bcav_0303   347 VTDAVpRDRLLLLDLWAEHAP-------VWDDGRGIAEHQWLWCAVHNFGGRFSVHGDLHGLARDLGGVLDdg-arTGG- 417  Beutenbergi...
jgi:Bacsa_2394  339 MMKNLkNGDLLILDLFSECRPmwg-ipsIWKREKGYEQHDWLFCMLENFGANVGLHGRMDQLLNNFYLTKnn--plAAH- 414  Bacteroides...
EGQ13735        356 MTDGLpAGSLTVLDLFSECRPmfg-apsIWKRAEGYGQHDWLFCMLENFGGNVGLHGRMDQLIGNFRLATspqsplQQAr 434  Prevotella ...
jcvi:PRU_1852   335 MVDDMkTGDLLVLDLFSECRPmfg-ipsIWKREQGYKQHQWLFCLLENFGANVGLHGRMDQLLDNFYMLQss--kfQAQs 411  Prevotella ...
CCX48275        380 LIDSLpPDDVLVLDLFAESMPqcgdpssPWYRPEGFGSHPRVWCMLLNYGGNVGLHGKLHHLPAAYYSQTGds------- 452  Bacteroides...
CCY34524        354 MIRSIpRGDLLVLDLYSESRPqwgdpssSWYRPEGFDGHDWLYCMLLNFGGNVGLHGKMQHVIDEYYKADss--rfSTT- 430  Alistipes s...
CDA42333        358 VLDKVeKGKLIVLDLFSDAHThf----------ndYKGHDAVYCALPNFGGRTGLFGRLSKIMTDFFTQKSty------- 420  Prevotella ...
CDE87068        303 VLDRVtKGRLVVLDLFSDAHThf----------gdYKGHDAVYCMLANFGGRTGLFGRLTKIMEQYFAEKKqh------- 365  Prevotella ...

4XWH_A          415 --MVGTGMAPEGISQNEVVYSLMAELGWRK 442  human
IGS:B005_5065   381 hpPEGIGLSMEATRNNPAFFELVVDQAWTR 410  Nocardiopsis alba ATCC BAA-2165
jgi:Bcav_0303   418 --FTGVGMAMEALENNPVFYELLTDLVWER 445  Beutenbergia cavernae DSM 12333
jgi:Bacsa_2394  415 --LKGIGLTMEGSENNPVMFELMCELPWRP 442  Bacteroides salanitronis DSM 18170
EGQ13735        435 rhLRGIGFTMEGSENNPIMFELMSELPWRT 464  Prevotella dentalis DSM 3688
jcvi:PRU_1852   412 skLKGIGFTMEGSENNPVMFELMSELPWRP 441  Prevotella ruminicola 23
CCX48275        453 -lMQGIGMTMEGIENNSILFELLSELPWRD 481  Bacteroides sp. CAG:927
CCY34524        431 --MIGVGLTMEGIENNPVMYELVSELPWRP 458  Alistipes sp. CAG:831
CDA42333        421 snIKGIGATPEAIEQVPVLYDALFELPWRS 450  Prevotella sp. CAG:5226
CDE87068        366 gnIKGIGATPEAIEQVPVLYDALFELAWRN 395  Prevotella sp. CAG:891
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