pfam16501: SCAPER_N (this model, PSSM-Id:374584 is obsolete and has been replaced by 406813)
S phase cyclin A-associated protein in the endoplasmic reticulum
SCAPER_N is a short highly conserved region close to the N-terminus. SCAPER is localized to the endoplasmic reticulum and is a substrate for cyclin A/Cdk2. It associates with cyclin A and localizes to the ER. One theory suggests that SCAPER functions to create a local high concentration of cyclin A2 in the cytoplasm. Alternatively, SCAPER might be acting to sequester a portion of cellular cyclin A2 that could then be readily available for nuclear translocation, which may be needed for exit from G0 phase.
Jiyao W et al.(2023). "The conserved domain database in 2023.",