Conserved Protein Domain Family
SARG

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pfam15385: SARG (this model, PSSM-Id:373807 is obsolete and has been replaced by 464692)
Specifically androgen-regulated gene protein
This family of proteins is found in eukaryotes, the function of this protein is still unknown but it is thought to be an androgen receptor. Protein expression is up-regulated in the presence of androgens, but not in the presence of glucocorticoids. SARG tends to be highly expressed in prostate tissue. Proteins in this family are typically between 340 and 587 amino acids in length. There is a conserved EETI sequence motif.
Statistics
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PSSM-Id: 373807
Aligned: 24 rows
Threshold Bit Score: 393.354
Created: 25-Apr-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
ELK03285      33 SGSSDSSYDFLSAEEKECLLFLEETIGSL-DTEADSGLSTDESEKATTPQSP---------------REL---PI-TQPA 92  black flying fox
EGW00962       9 SGSSDSSYDFLSAEEKECLLFLEKTIGSL-EAEADSGLSTDESEPATSPRSF---------------RAL---PI-TQQA 68  Chinese hamster
Q8BI29        33 SGSSDSSYDFLSAEEKECLLFLEKTIGSL-EAEADSGLSTDESEPATSPRSF---------------RAL---PTaTQQA 93  house mouse
XP_001372705  33 SGFSDSSYDFLSAEEKECLLFLEETIGSLeDKEADSGLSTDESQPAT-PQGP---------------R--------TQPV 88  gray short-tail...
2_pfamImport   1 SGFSDGSYDFLSAEEKECLLFLEETIGSL-DRETDSGLSTDESEQALTPRTG---------------RPQ---PV-GLLT 60 
ETE62284      36 lEMSDGGFDYLTVEEKECLMFLEETLHSL-DAEADSGLSTDDAEAVEPSKLP---------------RTW---P--TRDV 94  king cobra
XP_016850963  36 SEMNDSGYDYLSVEEKECLMFLEETLDSL-DAEADSGLSTDGAETS---KHP---------------RTW---P--TRDV 91  green anole
XP_003438845  15 SGYSEDSMDHLSAEERACLTYLEETIEAL-ETQEDSGVSNDESHHESLTEKA---------------DQMrvnDI-STLM 77  Nile tilapia
XP_005987741  35 sassddsYNHLSAEERACLLFLEETIVSL-ETEAGSGLSTDESERMDKLSPR---------------RNI---TK-TELL 94  coelacanth
XP_023196649  33 saWSEDSMEYLSAEEKACLMFLEETIEAL-EVQEDSGLSNDEPDMWSKTETQdqirsndvptemlksGSL---RI-STLS 107 southern platyfish
ELK03285      93 PQGHP-------EEKILLQPSlGPRRVTQSSSR----HLPEPQGLGLRSGSYSLPRNIH-ISK-NQNLliekhnpgktRK 159 black flying fox
EGW00962      69 PQGNP-------EVTDIQQVP-SPKRVPQSSG------PPESPSLGLRSGSYSLPRNLH-LGR-SQNL----------RE 122 Chinese hamster
Q8BI29        94 PQGKP-------EATDIQQVP-VPKRVAQPSC------PPESHSLGLRAGSYSLPRNLH-LGR-SQNL----------RE 147 house mouse
XP_001372705  89 LQGYQ-------EERLTQGRP-EQKRDIQSTTT----RL--RQDLSVKSGSHSLPRNIH-INR-DQSL----------RE 142 gray short-tail...
2_pfamImport  61 PQGKAyfsewqrAGVVVQH----GRRVSYPPA------PSERRALMQYEGKWAEPSQVEtVGKvSQLL----------LK 120
ETE62284      95 PKELD-------TDCLGKHKQ-IDSKDNTSLSG----SIPAAI---LSPGHHSLPKNIM-------------------TK 140 king cobra
XP_016850963  92 PKGLD-------RENLINHR---KNEINGIKSV----SDPVDI---PSPGHRSLPRNII-------------------VK 135 green anole
XP_003438845  78 PNGSK-------SDQ--------KSFLSDEVPT----APPASTALATE-GKTQL--NQI-------------------SE 116 Nile tilapia
XP_005987741  95 ADSLV-------ETTRDGSHP-APSELCKKKNGgklsALLVPTPLVLTAGSNKLQSGQK-SDY-KITK----------ST 154 coelacanth
XP_023196649 108 PH-----------------------------TT----ADSPSAGLTTECGTEHLAANQN-------------------SN 135 southern platyfish
ELK03285     160 NT----TQTNSHLPA-KPEGFIPDPEKGQVSQSS--EAN-------------------------------------QAPA 195 black flying fox
EGW00962     123 SA----TQTNSHGSQ-TPGVYLAEPEKAQTSQTT--KPF-------------------------------------QSPA 158 Chinese hamster
Q8BI29       148 SA----TQANSPVSE-ASEVFLEEPEKGQTSQGAkaKTI-------------------------------------QPPA 185 house mouse
XP_001372705 143 GSacrpSQSEGHIPR----GLVLAPLGHRTSRVV-------------------------------------------PPV 175 gray short-tail...
2_pfamImport 121 SS------GFSGLPFhREEGECVLDEGVLGEQGWkqRVS-------------------------------------YPPA 157
ETE62284     141 STvqtsKIFVAEAPEtNADELKTLPPLHPTLWDSskHGTldv-------------------------------lkeVPEI 189 king cobra
XP_016850963 136 SVpktaNISLVEATSfKTENQKDLPQIYLTSWGSpkNETldi-------------------------------sndQFKT 184 green anole
XP_003438845 117 PQdsplIPESSTHTKiLSSAMQTEMSSSATNEDA--DPE-------------------------------------SVKS 157 Nile tilapia
XP_005987741 155 SMamdsSDNSSECNVdVVDGLSSLQIVTDKGRPQ--SPP-------------------------------------SFKQ 195 coelacanth
XP_023196649 136 PQsastSAVGMKYVKtEDLGVETGPLVSNSGYTTssSDKtvdvskldgdlvlenvtnsgdasendldiippptdfrDEPE 215 southern platyfish
ELK03285     196 -----GPWEPllwtqhstpdqrlsespsqssvgktasvrgqgsrALDLD-TALIPPPEAFRDAQPEQ------------- 256 black flying fox
EGW00962     159 -----PSQET----------------------------------TLDLN-TVLIPPPEAFQDIRPKQ------------- 185 Chinese hamster
Q8BI29       186 -----PSQKG----------------------------------TLDLS-TVLIPPPEAFQDIRPKE------------- 212 house mouse
XP_001372705 176 -----SPGTP------------------------------------ELE-EVLLPPPEAFRDTYQEQdtrrsqf------ 207 gray short-tail...
2_pfamImport 158 -----PSERR------------------------------------ELD-LVVIPPPEAFRDPHLEQesllagl------ 189
ETE62284     190 -----GTQGR----------------------------------ISELE-SVVIPPPEPFQDQRKSHiviqhesiltdsw 229 king cobra
XP_016850963 185 -----TTQSK----------------------------------VSDLE-SVVILPPEPFQDHKQSYskrdqepqflnkv 224 green anole
XP_003438845 158 tivcpGSSTN----------------------------------TSETD-LSVIPPPLNFRDEPDS-------------- 188 Nile tilapia
XP_005987741 196 -----SARHA----------------------------------QKSVSlTALISPPEPFRDQNEK-------------- 222 coelacanth
XP_023196649 216 -----PDLLPeamtvv----------------------pppaamTVEA--MTVVPPPETMTVVLPPEamtvvlppetitv 266 southern platyfish
ELK03285     257 ---------------CGEDGLPE---GPGEqsptpLLHTLL-----SSQKRKETSSELMSQKP--SE------------- 298 black flying fox
EGW00962     186 ---------------SREESPLK---ELGEkrytpQAHSLV-----SLQKKE--PSETMSHKA--TE------------- 225 Chinese hamster
Q8BI29       213 ---------------SGEESPPK---KPGEqthtpQVHSLErs--pHSQKKVEMSSETVSHKA--TE------------- 257 house mouse
XP_001372705 208 ---------lkektrSGQDSLPLp-----------RAAP-------VTQEKKEVFLETMSQGT--KEv------------ 246 gray short-tail...
2_pfamImport 190 --------lregdqrAGRGRTEVk--AQENlvqwpQN---------PPARREEAISQLMSHRT--RQ------------- 235
ETE62284     230 k-haengatshyeskRNQGVTEEyagRAVQqefppEMM--------ETAAGNEFFLKSVSPKC--NK------------- 285 king cobra
XP_016850963 225 sqtveivlpphfevrKSFDHVERy--EATQqepspEKA--------DLAREKEVTLKSVSPKG--NK------------- 279 green anole
XP_003438845 189 ---------------------------PSQpvkvkDLTPSVgi--sRKKPGPTFDLEQIRQRA--SV------------- 224 Nile tilapia
XP_005987741 223 ----------------------L---HKLSeiqlpLQTSVEkp--dNRSKQND-----ITQKQ--PK------------- 255 coelacanth
XP_023196649 267 eamtmippletmtvvPPPAAMTV---EATSvvpppEATAPPppsnsFTKQKQTVDVEQMRMRAsvKRsvvdssaaedsss 343 southern platyfish
ELK03285     299 ---------------------R----GSVGAPGQSRPPPAM----------------------------------SSQNS 319 black flying fox
EGW00962     226 ---------------------K----GWTEGPQQPQLPPTQ----------------------------------SSQNT 246 Chinese hamster
Q8BI29       258 ---------------------K----GWTEGLQQPQQPPAQ----------------------------------SSQPT 278 house mouse
XP_001372705 247 --------------------lE----GLPRQPGLPLPL-------------------------------------SSENL 265 gray short-tail...
2_pfamImport 236 ---------------------G----DPEGTPGLLLPPPGF----------------------------------SSETM 256
ETE62284     286 ---------------------------------------------------------------------------KSSEE 290 king cobra
XP_016850963 280 ---------------------------------------------------------------------------KSFEQ 284 green anole
XP_003438845 225 ---------------------KknltSPVTKEPQIKPPPDE----------------------------------SLSLL 249 Nile tilapia
XP_005987741 256 ---------------------Rl--eNVEGSIAQNQTPHGGnefsgwssskraashshqlelsreqpvnppavppLHEPL 312 coelacanth
XP_023196649 344 kasevasllpqmnpptepsepR----N----------------------------------------------------- 366 southern platyfish
ELK03285     320 -------RAADAPIPSGGNPNAHLAPL-T-APKPRKLPPNIVLKSSRS---SF--HSNPQNWL------SRHSEAAPGDS 379 black flying fox
EGW00962     247 -------RAEEALLPSGVKPNTQQAPL-T-ASKARRLPPNIVLKSSRS---SF--HSHPQNWL------SNHTEAT--DS 304 Chinese hamster
Q8BI29       279 -------KAEELSLPSGVKPSIQQTPL-T-ASKARKLPPNIVLKSSRS---SF--HSHPQNWL------SNHTEAT--DS 336 house mouse
XP_001372705 266 -------GSENLTIPLGDEKSPKFAPP-T-APKSRKLPPNIILKTSRS---NF--PSDPQNRF------SHRSQATSRDS 325 gray short-tail...
2_pfamImport 257 -------GPGNSPSEQEGDLRPHPGPP-T-APKPRKLPPNIILKASRG---SF--HNNPQNWL------SHRPEVSHGDP 316
ETE62284     291 ivnhreiDHKHILEESQLDSSFKQGPP-T-APKPRKLPPNIILKTSKSnvaSV--NIDPTHKIkvslpfSGRPRAATGDF 366 king cobra
XP_016850963 285 mlgvqenDQKPTQEETSLDFSPKQGPP-T-APKPRKLPPNIILKTSRSnvvSY--NIDPNHKLkvlspaNGRPRAATGDF 360 green anole
XP_003438845 250 -------TSSQIVAPSSPESAEPKSPPvV-APKPKKLPPNIILKSHKM---------TNSDGN------SVHPALNSSEQ 306 Nile tilapia
XP_005987741 313 lekkvwhSSLSAPAVETLETKIKQGPP-T-APKPRKLPSNIIIKTSHD---PLfvASHGSGKV------VSR-EVSSNDS 380 coelacanth
XP_023196649 367 -------------------------PP-AvAPKPKKLPSSIILKSPTT----------PTHGN------PGHSVPSQGDR 404 southern platyfish
ELK03285     380 GL-----VPSSLQEQRKARKEALEKLGLPQDQ-DEPSPQLSKPTSSIRLKgth------aqAP--APAPAQPAFPTQVSa 445 black flying fox
EGW00962     305 GP-----VPSSLQEQKKARREALEKLGLPQDQ-DDPSLLVNKHTSTLKVKeaq------aqSPsqALATVQQASPALAPe 372 Chinese hamster
Q8BI29       337 GP-----V-SSLQEQRKARREALEKLGLPQDQ-DDPSLLVNKHTSTLKVReaq------pqTPsqARAPARPASPALVSg 403 house mouse
XP_001372705 326 TPdhassASSGLQEQRRARREALEKLGLPQDQsDEPSLQRAKSGSILRSRqsppqastsapAPvrAPAPAPAPAPVRAPa 405 gray short-tail...
2_pfamImport 317 VPersspAHLALQEQRRARREALEKLGLPQDQdSEPNLHWTKPNSSpl-----------aqPPtsAPAAVSPSPLARDPs 385
ETE62284     367 SMd---kTYALQKEQGRARREALEKLGLPLDNeKNPDDQVIKTSIYPKARem---------------------------- 415 king cobra
XP_016850963 361 SMe---kVHSLQKEQERARREALEKLGLPLDNeKDPEDHVAKTSAYSKSRem---------------------------- 409 green anole
XP_003438845 307 RP---------FLDPHKVRMEALRKLGLLKSS-EEESIPNQSSKLPLKARvs-------waAPssSSPPISPAAPNE--- 366 Nile tilapia
XP_005987741 381 SQ-----AESS-------------------------NPPSGKNQVLLKPDem-------eqQKarLEA------------ 411 coelacanth
XP_023196649 405 ----------MLLDPQKVHMEALKKLGLLKDN-KEEASRAVSPKISLKSAsh-------kwSPasPSPPVSPAALLTPP- 465 southern platyfish
ELK03285     446 avpvaekasapvptqgpspvkapaPEPALAQGPFPGKVLVPAQEPTPGKV-PAAKSMPISI------PKAPGV----SSP 514 black flying fox
EGW00962     373 aasa---------------agktsPV---KAVTSSGKSWIHAQETPPGKV-AAAKSMPIPV------PKTSKA----NSS 423 Chinese hamster
Q8BI29       404 tasa---------------agkvsPKKAVAPMDSLSKGWIPTQETPPGKV-AEAKSMPIPI------PKTLKE----NSS 457 house mouse
XP_001372705 406 papapa------------pvrapaPAPAPAPVRAPAPVSQVLASGPSARA-QGPPSTPIPI------PKPTRVssvdNSP 466 gray short-tail...
2_pfamImport 386 pptp---------------aliqaASPPSARAPAPG----LTQTPAPARP-PAPASAPVPI------HQDARV----ENP 435
ETE62284     416 -------------------------------sYTDSRENVNMDDITLNKK-SVQQSDQTDV------KEVQPT------- 450 king cobra
XP_016850963 410 -------------------------------sQIYSRENVQTENITHNRN-PDQKHAQIDE------EENYAG------- 444 green anole
XP_003438845 367 --------------------------PPSSQSYNLPPASVTVQPLNPGAIlPSNTSTALTVldpdilPAPADF----SDP 416 Nile tilapia
XP_005987741 412 ----------------------------------LKKLGLLKDEPN------GSHAGPVHL------PKSSRLr---EAP 442 coelacanth
XP_023196649 466 ------------------------VTPSLTPVISPLQAIVPQQSVLAPIMsPSASSASPPIedvdilPAPAAF----SDG 517 southern platyfish
ELK03285     515 LSQPKPNSGL---T---LQESN-IPGL---RQMN---FKSNTLERSGVGLSSYLSAE--KEPSPQTSTSLGKGSFLNKIS 579 black flying fox
EGW00962     424 LTQPKPDPLL---T---LQESS-IPGL---RQIN---FKSNTLERSGVGLSSYLLAAe-EDTKCQTSTSLGKSPTLDKVS 489 Chinese hamster
Q8BI29       458 RTQPKPDPRL---T---LQESS-IPGL---RQMN---FKSNTLERSGVGLSSYLSAAekKDPSCQTSTSLGKSPFLDKVS 524 house mouse
XP_001372705 467 PAQSSPGSRL---A---LKEGS-IPGL---RQMN---FKSNTLERSGVGLSSYLLAA--KDNAPQTSTSLGKVPILEKTS 531 gray short-tail...
2_pfamImport 436 PSRPKPDQSL---A---LAEGS-IPGL---RQLN---FKSNTLERSGVGLSSYLSAE--KDVGPKTSSSLGKVSFLEKIS 500
ETE62284     451 -------------------EIS-ISRI---KQAN---FKSNTLERSGVGLSSCIISGs-EGENFKNN----KRSFLSKIT 499 king cobra
XP_016850963 445 -------------------VNN-IPGT---KQTI---FKSNTLERSGVGLSSYICPGt-EDQNIKNSSSSGKMSFFEKIT 497 green anole
XP_003438845 417 IELSPSENHP---SavkDATSFtYPGLv--KQLTppkGKSASLGRSEVGVSRYTAGQdfSEASQGTSI---------NQN 482 Nile tilapia
XP_005987741 443 ATKQAVSSDLerkS---LQSSDqLERP---RIGN---VRSHTLERSGVGLSSDLAKK--KQAGASKESSITNKQGSTNMS 511 coelacanth
XP_023196649 518 FGLSGDE--LpavT---EAPFStLPNTsppKVIN---MKSATLERSGLGLSRQMFNQslLEITDG------------EQD 577 southern platyfish
ELK03285     580 PNVLRNSRPRPASLGTGKDFAGIQVGKLA---DLE-QEQSSKH------LS--YQGQS-RDKLPRPPCVSVKISPKGIPD 646 black flying fox
EGW00962     490 PSVLRNSRPRPASLGMAKDFTEIQGGKLV---GLG-QGQHSQQ------LS--FKGQS-HDKLPRPACVSVKITPKGIPD 556 Chinese hamster
Q8BI29       525 PSAFRNSRPRPASLGMGKDFAGIQGGKLV---GLE-QDQCSQQ------PS--FKGQS-YDKLPRPPCISVKISPKGIPD 591 house mouse
XP_001372705 532 PNVLRNTRPRPASLGGGKDFASIQVGKLA---DLE-QERNSQR------FS--YPGQS-RDKLPRPACVSVKITPKGIPD 598 gray short-tail...
2_pfamImport 501 PSILRNTRPRPASLGTGSDFAGIQVGKMA---DVE-QERNEKR------LS--YPLQS-RSKLPRPPCVSVKITPKGATD 567
ETE62284     500 PNFLRNNRMRPASLGTGKDFVDLKENKQH---NVE-WDKSHDR------RS--YPLQH-PSKLPRPACVSVKITPKGATE 566 king cobra
XP_016850963 498 SNFIRNTRPRPASLGMGKDFVDLKENKAH---NDE-LEKSDKR------RS--YPYQP-ASMLPRPPCTSVKFTPKGVAE 564 green anole
XP_003438845 483 LNQLRNHRPRPASLGSRKEFSSAQAEGLEagpSIT-KEPASQKalpahtPF--HHSRD-TQKLPRSQGISVLICPRSENE 558 Nile tilapia
XP_005987741 512 SKVLRNTRPRPVSLGTGKDFKNI--ENQT---DVQvLEKNIIR------RS--FPSQSfTQRMPRPPGISVKITPKGSTN 578 coelacanth
XP_023196649 578 PKLLRNTRPRPASLGTRKDFSHTKGEGLV---ASGtSESQKPQ------PTqaFHRRE-SSKLPRSQGISVMICPRAENE 647 southern platyfish
ELK03285     647 EHRREALRKLGLLKE 661 black flying fox
EGW00962     557 GHRREALKKLGLLKE 571 Chinese hamster
Q8BI29       592 GHRREALKKLGLLKE 606 house mouse
XP_001372705 599 EHRREALKKLGLLKE 613 gray short-tailed opossum
2_pfamImport 568 EHRREALKKLGLLKE 582
ETE62284     567 ENRKEALKKLGLLKE 581 king cobra
XP_016850963 565 EHRREALKKLGLLKE 579 green anole
XP_003438845 559 EDRRGALKKLGLLRD 573 Nile tilapia
XP_005987741 579 EDRQEALKILGLLKE 593 coelacanth
XP_023196649 648 EDRRQALKKLGLLRD 662 southern platyfish
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