Conserved Protein Domain Family
Cep57_CLD
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pfam14073: Cep57_CLD (this model, PSSM-Id:372901 is obsolete and has been replaced by 464080)
Centrosome localization domain of Cep57
The CLD or centrosome localization domain of Cep57 is found at the N-terminus, and lies approximately between residues 58 and 239. This region lies within the first alpha-helical coiled-coil segment of Cep57, and localizes to the centrosome internally to gamma-tubulin, suggesting that it is either on both centrioles or on a centromatrix component. This N-terminal region can also multimerize with the N-terminus of other Cep57 molecules. The C-terminal part, Family Cep57_MT_bd, pfam06657, is the microtubule-binding region of Cep57.
Links
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Statistics
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PSSM-Id: 372901
Aligned: 35 rows
Threshold Bit Score: 168.529
Created: 29-Apr-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EDV24628      62 AVISALQGLQEKIKKLEIERCLAEENLKTLTTETAHYKEIL---Q---KEQSAVHDNRNaATKHNQ-------------- 121 Trichoplax adha...
XP_011615953  57 AVVNALKNLQRKIRQMELEKKETETNYQRLSHDVTHHKE-----G---SSSRSVAHQPGpTGSARE-------------- 114 torafugu
6_pfamImport   1 AVVDALKTLQEKIRRLELERKQAQKSYGQFSQDAWRRPEVTgslA---VHSQAVAGQPAtGNSGKK-------------- 63 
XP_005802703  63 AVVDALRTLQEKIRRLELERRQAERSYTQFFQDARKRQQDF---T---SQSRTEATLPG------T-------------- 116 southern platyfish
XP_003449919  65 AVVDALKTLQEKIRRLELERMQAEKSYQQFSHDAQKHPQVT---T---LYSQTAASLPGtDNSARR-------------- 124 Nile tilapia
XP_015205104  69 AVIAALKTLQAKIKRLELERAQAESSMRQLSEKAQWYRGEP---E----QPKTSNLNVQkGATQDT-------------- 127 spotted gar
XP_020570313  68 AVVDALKNLQDKIRRLELERMQTQKTYLQVSHDAQKQPQVL---T---SE--TAASVPAtDFSAKT-------------- 125 Japanese medaka
XP_005160735  69 AVIAALKTLQEKMRRLELERVHAVKNVHHFSQPTRHQEDVS-------ASKEQEHNMRDnDSTQRK-------------- 127 zebrafish
CAG03609       1 AFVNALKNLQQKIDQMELEKKQAKAKNQQLSHRVTNHQPVS---SpyvEAALPTAGQPGpDGWNQEgeggsgrqasavsd 77  spotted green p...
AAI18771      59 ALISALKTLQEKICRLELEKTHARDRLTNLTRVAGEHKKVL---E---SEKQSAELAAKeATNQQN-------------- 118 tropical clawed...

EDV24628     122 ------------ELEAQLAATEGRCSLLESQLAQMRKLVTQAENDRSSALQRTLELEKRNsSQVSREMLLQFDDLKKLER 189 Trichoplax adha...
XP_011615953 115 ------------EYLSKLQSVEARCKILEKQLNRMSKMVENGNKERKAVIEQQSLLQNQQ--PSSSEIRTQHDKLEKLET 180 torafugu
6_pfamImport  64 ------------ELDSKMQSAETRCKVLEKQLDYMRKMVESAKKERNVLMENQASLQNQQ--PCSSNTQCQRDKLEKLES 129
XP_005802703 117 ------------AVDQKLQSAEARCKVLEKQLEYMKKMVANVKKERNVLMENEASLQKQQ--LSSPNNQYQQEKLEKLES 182 southern platyfish
XP_003449919 125 ------------ELDSKLQSAEARCKVLEKQLDYMRKMVENAKKERSALMENQASLQSEQ--KSSSNSQIQREKLEKLES 190 Nile tilapia
XP_015205104 128 ------------ELVAQLRSAESRCCLLEKQLDYMRKMVENAERDKNAILEKQVSLQKEK-LKDQEQVHGKLEKLEMLEQ 194 spotted gar
XP_020570313 126 ------------DLDLKLQSAESRCKILEKQLEYMRKMVENAKKDRSAVLENQALLQNQQ-T-SNLNHQTQQEKLEKIES 191 Japanese medaka
XP_005160735 128 ------------VLVSKLHSAETRCSLLEKQLNYMKRMVECAEKDTVTHTDRKDSLPTEH-THADPQIQAQLNKLERLEK 194 zebrafish
CAG03609      78 qiwclnglfmlaEYTLKLQSVEAQCKILEKQFNYMRKMVEIGNKERKAVAEKQVLQESAN-Q--NSDVKSQGKKLERLEI 154 spotted green p...
AAI18771     119 ------------DIGKQLNNAKQRCSLLEKQLDYMKEMMENADTQKTTIHEHQMLTQKEQ-----KEIQSKLKKLEVLEK 181 tropical clawed...

EDV24628     190 EHIQLKASYALAESRIQELENQLKEEQHSKKLIQEKAAELQTLLETNRI 238 Trichoplax adhaerens
XP_011615953 181 ECFNLSRTQALAETKLASLEEKLLREERERLLVQEKADQLQKELDTNlq 229 torafugu
6_pfamImport 130 ECLKLSQTQTLAETKLAILEQKLLKEEHERKIVQEKADQLQRELEIN-- 176
XP_005802703 183 QYLKLSKTQTLAEMKLSILEQKLLNEEHERKLVQEKADELQRELDVNlr 231 southern platyfish
XP_003449919 191 ECLKLSRTQTLAEMKLSILEQKLLKEEHERKLVQEKAEELQREFDVSlr 239 Nile tilapia
XP_015205104 195 ECLRLTSTQSMAEKKIQQLEHKLLEEEHQRKLIQEKAAQLQTGLEMNRI 243 spotted gar
XP_020570313 192 ECLKLSRTQTLAETKLAILEQKLLQEEHERKLMQEKAEELQREFDISlr 240 Japanese medaka
XP_005160735 195 EYLRLTNTQSVAERKIELLEQKLLEEEHERKLVQEKAEELQRELENNIL 243 zebrafish
CAG03609     155 EYSKLSRTQALADTKLAILEEKLQKETCQRLLVQEKAERLQRELDTSlr 203 spotted green pufferfish
AAI18771     182 MCTRLSATHKSAETKIQHLEEKLSVEEQNRKALQDKAAQVQTSLEVNRI 230 tropical clawed frog
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