Conserved Protein Domain Family
SAGA-Tad1
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pfam12767: SAGA-Tad1 (this model, PSSM-Id:372302 is obsolete and has been replaced by 463692)
Transcriptional regulator of RNA polII, SAGA, subunit
The yeast SAGA complex is a multifunctional coactivator that regulates transcription by RNA polymerase II. It is formed of five major modular subunits and shows a high degree of structural conservation to human TFTC and STAGA. The complex can also be conceived of as consisting of two histone-fold-containing core subunits, and this family is one of these. As a family it is likely to carry binding regions for interactions with a number of the other components of the complex.
Links
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Statistics
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PSSM-Id: 372302
Aligned: 129 rows
Threshold Bit Score: 75.787
Created: 1-May-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_006366269            5 HQHSRINLSELKAQIVKKLGPEGSKQYFHYLSRLLSLKISKAEFNKLCFRILGr-------eNIPLHNQFIRSILRN--- 74  potato
Q5KHJ0                 51 SSQMRVDIHAIKQELHDVLG-EAGLPYWKSLNAYLVGQLGRAELEDMVRGWLKg-------dHLHLHNKLLSSLLTN--- 119 Crypto...
EPB81930               29 TTNGRQDVLALKQRLADALG-ENGPLYWDALRDFVMGKLNRQEFDFYANLYLSr-------qHAHLHNAFILSTVHN--- 97  Mucor ...
EDP42028               14 algMAVDPRAVKVRLFEKLG-SFADEYWQLLGALCTAAIDRAEFHNRVKAKLPs-------eCVPLHNALVLSILAEans 85  Malass...
KIS68213               19 HRPIRADTLDLKQKLAVALG-QNGARYWQTLVQFLKGAIDRSEFEALAHKALKt-------eHIHLHNALILGILYN--- 87  Ustila...
EGG09929               20 sNHSRSDTLSIKQSLIQLINPQDGLHYWSSFTNFIKAKIDRREFEEEVSRILNtd------qLVGLHNSLVLSILYN--- 90  Melamp...
WGS:AAWC:PGTG_13127.3  17 pPNKRADTLAIKQAIAEALSEDEGLAYWTSLVKFLTGKLDRTEFEVQTAYLLKse------tLVGLHNALILSILYN--- 87  Puccin...
OAV96244               17 pPNKRADTLAIKQAIADALSEDDGRAYWASLVKFLTGKLDRTEFEAQTARLLQse------sLVGLHNALILSILYN--- 87  Puccin...
XP_016273932           32 pPAKRTNLVELKLRLAELLTPEQGAVYWAGLGDFVCGRINRQEWDEVLKRAFGkdra-rraeAVKLHNALLLAILYN--- 107 Rhodot...
KDE02672               62 tvPKRADLLSLKLKLADLLPPHLGQLYWTSLVEFMTGQINRDELQGVFERVLGkgkqgeqdtALQLHNALLLSILYN--- 138 Microb...

XP_006366269           75 -A--------CSAKV-----P-PPI-NEGGIvkpgvavgskqplddaydqngvhvssnqasgqpglsngavlplsprkaR 138 potato
Q5KHJ0                120 -AsipthdgtSSSLQqrhkrQrPSVnDPDFDv----------------------------------------------dD 152 Crypto...
EPB81930               98 -AqtntpppsKHRLVgwakrKrgkdgs----------------------------------------------laadgdS 130 Mucor ...
EDP42028               86 gSsasaasgtGASVRaltspIqPrravl-----------------------------------------------ndstD 118 Malass...
KIS68213               88 -AsadvpgpsSRASRritriLpdgtt-------------------------------------------------iteeE 117 Ustila...
EGG09929               91 -TtrpesppiNPPGRpnlytT-GQGwYKRKRvqipinqi---------------------------------hqsksklE 135 Melamp...
WGS:AAWC:PGTG_13127.3  88 -TtrpdpaisNPLKEpg-psTtGEGwHKRKRvpvppvp----------------------------------pkvktknE 131 Puccin...
OAV96244               88 -TtrpdpattNPLKDpetppTtGEGwHKRKRppappvap---------------------------------pkiktksV 133 Puccin...
XP_016273932          108 -TtrpflppsSVRHSgfhprGakkrg-------------------------------------------------laagE 137 Rhodot...
KDE02672              139 -TtriavppsTLRHSgfqvkRrLSApndpp--------------------------------------------nngsaS 173 Microb...

XP_006366269          139 TGYRDR-K------------AGDRRSVLGS--NGKNSFA-FQqA--------TTm-ESsdfeiikengdlnppnfkgavh 193 potato
Q5KHJ0                153 TLIESKrR------------VEGWVMNLGKkeRARVKKAlAGaAekgvlgaaAAaeKDmwggvg---------------- 204 Crypto...
EPB81930              131 EQDPKKrK------------LKSDVMALSKseRERLKALvKAgDknn--------------------------------- 165 Mucor ...
EDP42028              119 ESDDETePpvdgrasrglkrLRHLYAGLSDdeRKRLDQLsKQsAssthtsasVWagAGaellekkrkederrra------ 192 Malass...
KIS68213              118 EEEPSRkR------------LRNLVAGLPRkeRLRLKNLdKAgKlganavggAAslGWagsaadmlekkrkdeekr---- 181 Ustila...
EGG09929              136 ESDPKKrK------------LKETILSIGQreRNRIKQIpKEkEkekelyqkLGnpYHsknpqfdylsreklekv----- 198 Melamp...
WGS:AAWC:PGTG_13127.3 132 EKDPKKrK------------LKEAVMALGQreRNRLKQIaLLkEnelelnsnKFnpQQlaprqlsachylyperten--- 196 Puccin...
OAV96244              134 EKDPKKrK------------LKEAVMALGHreRNRLKQIaSLkEee----lvKLnaQQplprplsacqylyperten--- 194 Puccin...
XP_016273932          138 GGEVEEkRrr---------lLKDKVMALGRreRGDVKLLgTAsAgpasassgRGkgLAaveeerkrkrrag--------- 199 Rhodot...
KDE02672              174 EVDPLRkK------------LKTLVMSLGKreRREIKALvPTqTgvtataasTTsaAAllqqqdqaqlqaikeaggvvps 241 Microb...

XP_006366269          194 hhq--gtiqqidderqgfnqetakfsvmkrSLQNSV--SLQNKADKSr---dDGRD-----------LHARSQ------L 249 potato
Q5KHJ0                205 --------------------------------------------------------------ekrwsPYTSNS------L 216 Crypto...
EPB81930              166 ------------------------------------lrPFVDRLLGTrisrpPTLPiafdqlppnysQEYSKG------L 203 Mucor ...
EDP42028              193 ---------------veerrrareiklaigASHWRL-----SAMQTAaqtesIRSRlst-----tmqEALKRS------V 241 Malass...
KIS68213              182 -------------kvaedrkkvrqyksaigAKDWKG-----QAIHGNqqiaaVRSKlsl-----saqQAVMRA------M 232 Ustila...
EGG09929              199 --------------------------------------------------tntllaskmkissstlyQDYMRC------Q 222 Melamp...
WGS:AAWC:PGTG_13127.3 197 -------------------------------------------------vmntplaskmkissstlyQDYMRC------Q 221 Puccin...
OAV96244              195 -------------------------------------------------vmstplaskmkissstlyQDYMRC------Q 219 Puccin...
XP_016273932          200 ------------------ealseamggasrGGGGRI--EMDGVPRALrerekEGAPlpp-----tlsQDYLRL------V 248 Rhodot...
KDE02672              242 alakrelerererkrdkelvrlstlaaaleSGKGRGevDAIGGGTGGktdp-------------altQEYQRiiasssak 308 Microb...

XP_006366269          250 QAPLGvpfcpvsvggarrsvplaassrcvssSSFGALLDSVTLRERMEQISAEQGL-----DG--VAM-DCANLLNNGLD 321 potato
Q5KHJ0                217 IPPLA--------------------------LPTRHLPSSHQLALRLSQFAKLHDLsipstSSstAAAdDIGEFMAVGMD 270 Crypto...
EPB81930              204 MAPLC--------------------------VDLKELPSPETLHARMTSIALENGLl----GG--IGE-DVVNVMLFAAE 250 Mucor ...
EDP42028              242 ATPNC--------------------------IESQVLPDVHSLQDRMSLSAIEAGLs----GG--VHA-HAAAVALSALH 288 Malass...
KIS68213              233 QAPLC--------------------------VESKHLPDLDGLKDRMTLLAVENGLp----GG--VQP-QAAAMVLSALQ 279 Ustila...
EGG09929              223 QAPLC--------------------------SESKQLPDSDTLKDRMSLIAYDSGLv----NG--VDQ-SAASLALIALE 269 Melamp...
WGS:AAWC:PGTG_13127.3 222 QAPIC--------------------------SESKQLPDFDTLKDRMSLIAYDSGLm----NG--VDK-AASSLALIALE 268 Puccin...
OAV96244              220 QAPVC--------------------------SESKQLPDFDTLKDRMSLIAYDSGLm----NG--VDK-AASSLALIALE 266 Puccin...
XP_016273932          249 QTPLC--------------------------CESRVLPDSETLRDRMTATAYEEGLa----EG--VEG-RASTLVQGAME 295 Rhodot...
KDE02672              309 DSLLC--------------------------STSKLLPDVDGLRDRMTLIVFESGLv----GGgvVDE-RVGLLGVQAVE 357 Microb...

XP_006366269          322 SYLKGLIKSCLQFV 335 potato
Q5KHJ0                271 AHMGDILHGVVHLT 284 Cryptococcus neoformans
EPB81930              251 NYIKSSITSAISKR 264 Mucor circinelloides f. circinelloides 1006PhL
EDP42028              289 DYLQNILRRTF--L 300 Malassezia globosa CBS 7966
KIS68213              280 SHLQNVASSIITKI 293 Ustilago maydis 521
EGG09929              270 VHLKTILGDLLSLI 283 Melampsora larici-populina 98AG31
WGS:AAWC:PGTG_13127.3 269 VHLKTLLGDLLSLI 282 Puccinia graminis f. sp. tritici CRL 75-36-700-3
OAV96244              267 VHLKTLLGDLLSLI 280 Puccinia triticina 1-1 BBBD Race 1
XP_016273932          296 HHLKNMLAAVVSLV 309 Rhodotorula toruloides NP11
KDE02672              358 THLKNIIAHVVGLV 371 Microbotryum lychnidis-dioicae p1A1 Lamole
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