Conserved Protein Domain Family
TRAPPC-Trs85
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pfam12739: TRAPPC-Trs85 (this model, PSSM-Id:372281 is obsolete and has been replaced by 463688)
ER-Golgi trafficking TRAPP I complex 85 kDa subunit
This family is one of the subunits of the TRAPP Golgi trafficking complex. TRAPP subunits are found in two different sized complexes, TRAPP I and TRAPP II, and this Trs85 is in the smaller complex. TRAPP I, but Not TRAPP II, functions in ER-Golgi transport. Trs85p was reported to function in the cytosol-to-vacuole targeting pathway, suggesting a role for this subunit in autophagy as well as in secretion. The overall architecture of TRAPP I shows the other components to be Bet3p (TRAPPC3), Bet5p (TRAPPC1), Trs20p (TRAPPC2), Trs23p (TRAPPC4), Trs31p (TRAPPC5), Trs33p (TRAPPC6a and b) and Trs85p.
Links
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Statistics
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PSSM-Id: 372281
Aligned: 79 rows
Threshold Bit Score: 185.594
Created: 1-May-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_018652567  170 DPIRGFTELTQSQSNQQHHLPGs-----------rPFWFTE--NV---LKFYVLLHDGS-----SNikqscVDEIFNQ-V 227  Schistosoma m...
EEH51492      180 DPLGDATRMTEDGSSWPGGLPN-------------QPLLERagDVdvfARHYVLVHDARdatatRE-----AVAAKERiL 241  Micromonas pu...
Q57ZE9        177 ggVEGILKEFNELKRGQEIGEIwrnmp------------cmeeEM---HSHFLLLHDVTegpgmDEvn-----rMFAA-V 235  Trypanosoma b...
EEA08301      253 ETILDGLRTGISFTNIDGNSNYyhnqgyfrshylqETYLN---DF---PLVFILISDSSl----EDncnldVQSIISK-L 321  Cryptosporidi...
Q9BI63        129 NPLGEFSKMIQTQQTLYNTTSTlmipg----hcstPKWAAPhaKT---PRHYILLHDSRs----PRssterRDELLAQ-M 196  Caenorhabditi...
EFO84598      129 NPMGELSKMIQTQQTLYNTTSTlmip-----ghcsPKWASShaKT---PRHYILLHDSRc----PRsstdrRDEVLAQ-M 195  Caenorhabditi...
CAP33307      126 NPMGELSKMIQTQQTLYNSTSTlmipg----hcsaPKWSAPhaKT---PRHYILLHDSRc----PRgsserRDEVLKQ-M 193  Caenorhabditi...
EFX86884      148 NPMEQFQQLNDQLTQLMSSNGTvd----------gPRWFNM--LS---LRYHVLIHDACd----GEts--kAEELLQT-M 205  common water ...
EER12757      185 DPIEAFEQLMHEANMPPLAR---------------RGVLDP--DA---ARMKVLVHDPSrappgLD-----LDALLNR-M 238  Perkinsus mar...
ESS31117      653 SSSSSSSSFSSFSSSSSSDLPCs--------------------SS---AEPSAASYDVSe-----------IEALIAS-- 696  Toxoplasma go...

XP_018652567  228 KTTFGALnCHLLTIFTsssgnellgnnscvpnhllfnnpyqangiisrpntstivhtsenephsdpwlhhllphgyrpql 307  Schistosoma m...
EEH51492      242 ADAFGDAkVSVLPVNSs--------------------------------------------------------------- 258  Micromonas pu...
Q57ZE9        236 QSSLGHAnCALVKLNSisnpqnvknmdpsvwtdanpsfmdvp---------------sdtacravrysqqlesrsgspas 300  Trypanosoma b...
EEA08301      322 KQLFPENeFYLWNI------------------------------------------------------------------ 335  Cryptosporidi...
Q9BI63        197 CATYGNDnCQMLQLDSdsesaemkgvwdei---------------------------------------defndvlekgl 237  Caenorhabditi...
EFO84598      196 CATYGNDnCQVLQLDSdkspemkgvwqeid----------------------------------------efndvlekgl 235  Caenorhabditi...
CAP33307      194 CATYGNDnCQVLQLDSdsvspdmngvwnei---------------------------------------defndilekgl 234  Caenorhabditi...
EFX86884      206 RNAYGSHgCHLLVINSkpkkgsmvepglpapdpwlrflprkasksdasi-egetvvdgadagemelpgkvvegtnsqslg 284  common water ...
EER12757      239 QSNYSPKsCFILVV------------------------------------------------------------------ 252  Perkinsus mar...
ESS31117      697 --------DAPLPVASrlaccal-----------------------------------------------------gasp 715  Toxoplasma go...

XP_018652567  308 dhkLFPprdtsikscdNQITNDNNDPLTVEDSREACSQVFDVGK---------TPLidtsclpassis----------sy 368  Schistosoma m...
EEH51492      259 ---SSF----------SSSPHDDDIWTAHLERRMITAANASGAI---------TID------------------------ 292  Micromonas pu...
Q57ZE9        301 aggGGD-------------------SASSRVAAEPLLFPRVQAM---------FGKwp---------------------- 330  Trypanosoma b...
EEA08301      336 -----KgiskcscsesIFEEQKVDKPVSIGSYAHPYLDTTDYYM------------------------------------ 374  Cryptosporidi...
Q9BI63        238 eeaHQHstdai---apgpNGASNQQSPSSPTSSVATISSTMPAV---------GSVspnsh------------------- 286  Caenorhabditi...
EFO84598      236 eeaHKHstdtipstpgTNGGATSLQSPSSPT-FVSTISSTMSAV---------GSVspnsqq------------------ 287  Caenorhabditi...
CAP33307      235 eeaHKHssdsipntpgIKNT-----PLNSPTSLVSTISSSMSV----------GSVspnsqaa----------------- 282  Caenorhabditi...
EFX86884      285 slpKMPimdalqeamqEININSILAPSPSTSALSSLTRDESTNMknnlsqrsaVEIkddplnaglgmttsglsvdeadgt 364  common water ...
EER12757      253 ---------------------GEGQDPIPDIQALFRRGPITPAL---------D-------------------------- 276  Perkinsus mar...
ESS31117      716 pggSSAavcppsssavGAHAADCGMPTPAAQAAAYVRCSTLCCL---------D-------------------------- 760  Toxoplasma go...

XP_018652567  369 ssytflpsrYSEPHGQHLIQADRDRIHMFVYDFSVRALLPWVEKTMRSLNDQIA-HRMRLSRSFFNAtkkfftqavgggg 447  Schistosoma m...
EEH51492      293 ---------ETVKRGALLSKEDVAAHARVVKEYVAGSLLKSMEKRSRAANEKIAaTRKGLKNQLKSF------------- 350  Micromonas pu...
Q57ZE9        331 -------dgTAKVTGCYLSPENVRDLRAVMHHYLSQCLFTFIERKLRSLNTTVNeRRTTTLGKMAAWfrnk--------- 394  Trypanosoma b...
EEA08301      375 ------------NVNRFLTHSDMELLRSIIFSCVTKNFVLWIQNTMNRLYNTVNqSRKGIKSHLRMFwrrpkpevntsmn 442  Cryptosporidi...
Q9BI63        287 ----pnstvVWKSSKKLASLADAKAVQAILSKFLDVCLIPYVEKEMRFLYET-AgQKKGIGKSFTSMkr----------- 350  Caenorhabditi...
EFO84598      288 ---ssnnpaVWKTSSKIASLQDAKNVQAALSKFLTACLGPYVEKEMRMLYET-AgQKKSFTKSITSVssgm--------- 354  Caenorhabditi...
CAP33307      283 ---iqsnpiIWKSSSKIVSSQDAQNVQKVLSRFLSNCLAPYVEQEIRTLYEN-AgQKKSISKSVASVtmgf--------- 349  Caenorhabditi...
EFX86884      365 glilapsivESELHGGCLTTEDLDRIQGLVNDFCLKSLLPHMERQMRLLNESAS-ARKSTHRSLLSAtkrw--------- 434  common water ...
EER12757      277 -----------ERAAAGVQWSEIDDLQRLGTAIVTECAVPWAERKLAELDDNISqKRKGFRNAFSRFlrkpnlp------ 339  Perkinsus mar...
ESS31117      761 -----------TSFCVGLSWSDLHSLSAFIQHLVNTGILPWMERKARQLDGSIAtNRKGFRNQLRYLwrkprgmtaasqn 829  Toxoplasma go...

XP_018652567  448 gsnnttvnstnnlttlkiysnp-------------spietsannisnpcsptnpvivnnskgelstnttlTPQSISYAGP 514  Schistosoma m...
EEH51492      351 ----------------------------------------------------------------------WGRSTGASVK 360  Micromonas pu...
Q57ZE9        395 ------------------------------------------------------------------nevnKSKTESWVAA 408  Trypanosoma b...
EEA08301      443 sdsfls-----------------------------------------------tlgmtnaisnlddksqlfeSNIPLFTS 475  Cryptosporidi...
Q9BI63        351 ----------------------------------------------------------------------wfGSGTALSN 360  Caenorhabditi...
EFO84598      355 --------------------------------------------------------------------rkwfGTGSSSNN 366  Caenorhabditi...
CAP33307      350 --------------------------------------------------------------------skwlRTGSSSNN 361  Caenorhabditi...
EFX86884      435 ------------------------------------------------------------------fgssRPGGLQTTQT 448  common water ...
EER12757      340 ---------------------------------------------------------------gtevisgPIGSSQNVQG 356  Perkinsus mar...
ESS31117      830 svlssggagaggapsegsasssfspfasafpssatsvvanvaeqaggaaeallsavggaflgetassfsqSGSSSKAAPS 909  Toxoplasma go...

XP_018652567  515 VNHSTIv---------------YSQDSPESQMRRLADLAFLFQQYEVAYQTYNVLKRDFQNDSAWLHH-----AGAQEMS 574  Schistosoma m...
EEH51492      361 TEGDGA----------------YTPASQESQIRVAADLAFFLGDYETAASHYRLIQSDYKADKAWKRL-----AATQEAL 419  Micromonas pu...
Q57ZE9        409 RGNSRAm---------------YLAGSLEMQMRRAADLSLALADYDAAANFYRLCRAEALATVETRAFnkpliAAAQEGI 473  Trypanosoma b...
EEA08301      476 YKDTSAkkqlr-------spiiYSASTIEGQTRILADLCFLIGDFSSATQYYKQILSDYKLDKSYMCM-----GSTYEIL 543  Cryptosporidi...
Q9BI63        361 MATPIT----------------YAWDSSEMQTRRLADLLLMFGFPNSAFEQYRGLKRDLEADKAMAAH-----AVALEMC 419  Caenorhabditi...
EFO84598      367 LATPIT----------------YAWDSIEMQTRRLADLLLMFGFPGAAYDQYHSLKKDLEVDKAMAAH-----AVALEMC 425  Caenorhabditi...
CAP33307      362 LATPIT----------------YSWESLEMQKRRLADLFMMFGLPGAAYDQYHPLKKDLEADKAMAAH-----AMALEMC 420  Caenorhabditi...
EFX86884      449 VAVS------------------YHPESVQLQLRRLGDLAFLLGHYELAYHSYHSAKKDFEADQAWLHY-----AGAMEMA 505  common water ...
EER12757      357 RSTAEG----------------YTLSSLEWQIRLAGDLAFHLRDYTQALSYYRQVTPDFKQDHQWAVA-----AGAYEMA 415  Perkinsus mar...
ESS31117      910 RSEAPGsprrnglstqafvqsaYQLHAIEWQYRLLGDLQLFFGLHEAALQSFRSCAADFKQDKRWKQL-----GGACEMS 984  Toxoplasma go...

XP_018652567  575 ALSVYLQGatSQRQYPY---------------HLMDSAVATYLQSHl--------------------------------- 606  Schistosoma m...
EEH51492      420 GHALVMCK--PQQWAAEgppfre---srreaaAAFEAAAACYARANvhaagggqtvappgtpppgggggggggggvpggt 494  Micromonas pu...
Q57ZE9        474 GICHFLQG--RLLPssltpwraggtssknnsdCRLEVAMNDYDAC----------------------------------- 516  Trypanosoma b...
EEA08301      544 AVCQVATG--MDLEAVS---------------NLLLNACNSYQRSSdyysyslymrs----------------------- 583  Cryptosporidi...
Q9BI63        420 CVALHSAQ--PQLNANQfm------------iKYLETPVSLLIEHAk--------------------------------- 452  Caenorhabditi...
EFO84598      426 AVALHISQ--PNLNSKQyp------------iRYLDPPVKLLIEHAk--------------------------------- 458  Caenorhabditi...
CAP33307      421 ALALHSAQ--PHLNAKQfp------------iRYLDPPVKLLVEHA---------------------------------- 452  Caenorhabditi...
EFX86884      506 ALSVFLQNg-HNRTIPF---------------HYFDKALT---------------------------------------- 529  common water ...
EER12757      416 AVAAWLAH--ISTGGEVvavs--------emsRYMDNAVELYQKAGp--------------------------------- 452  Perkinsus mar...
ESS31117      985 AICLHLSGaprr-----------------eveACIEQAYNAYVKA----------------------------------- 1012 Toxoplasma go...

XP_018652567  607 ----------------------------------sPELELALRSTLLNFEA------------------LCSRGlyneaa 634  Schistosoma m...
EEH51492      495 gtpgpafapptptpggvaavaavvappagafdsvaERTLWATRAAYAHAAL------------------LTACG------ 550  Micromonas pu...
Q57ZE9        517 -----------------------------------EMNVYSLRVALLLYEF------------------CRtrtp----- 538  Trypanosoma b...
EEA08301      584 -------------------------iiflvislfnSPDLYSVDSEFSISDLsgsfrvkystiydsiidkVKSVIidmqnl 638  Cryptosporidi...
Q9BI63        453 ----------------------------------fRRYPSILRCAFNIADIysdl------------------------- 473  Caenorhabditi...
EFO84598      459 ----------------------------------fRRYPAVLRCAFNMAEIysnl------------------------- 479  Caenorhabditi...
CAP33307      453 -----------------------------------KKYPSVLRCAFHMAEIyadl------------------------- 472  Caenorhabditi...
EFX86884      530 -----------------------------------TMPYWATRCAVLASEC------------------LKATNqysdaa 556  common water ...
EER12757      453 -----------------------------------RFYRQAMRSAIIQSAI------------------LRGRTdspqkl 479  Perkinsus mar...
ESS31117     1013 -----------------------------------SAGRLALRCVLLGTRLtmdlltavplpfsppfspFLALQqsssps 1057 Toxoplasma go...

XP_018652567  635 va--------------------------------------------------------------------lirltsdeDD 646  Schistosoma m...
EEH51492      551 ------------------------------------------------------------------------------SD 552  Micromonas pu...
Q57ZE9        539 ---------------------------------------------------------------------------plvDR 543  Trypanosoma b...
EEA08301      639 dmnskyfs--------------------------------------------------------wilpndkgnysteyNS 662  Cryptosporidi...
Q9BI63        474 ---------------------------------------------------------------------------glhKE 478  Caenorhabditi...
EFO84598      480 ---------------------------------------------------------------------------glhKE 484  Caenorhabditi...
CAP33307      473 ---------------------------------------------------------------------------glhKE 477  Caenorhabditi...
EFX86884      557 lq--------------------------------------------------------------------lirltsedAD 568  common water ...
EER12757      480 l-----------------------------------------------------------------------ktngdiPD 488  Perkinsus mar...
ESS31117     1058 llstaeaaveaarrllaanaelpaldpraklptsllrrsegsakaaarpdgstgdsrdlrevketrdareskearegrDE 1137 Toxoplasma go...

XP_018652567  647 ------------------LISGLLIEQVAHCVLS-------------------LKRPMLR-----KFAFRMALAAHRYAR 684  Schistosoma m...
EEH51492      553 reaaipltrasaeeaqthARAALSLEAAATAYLR-------------------ADPPMAR-----KYAIHAVLAGHRYNQ 608  Micromonas pu...
Q57ZE9        544 ttalllhvqhrgmvgrskLQIAVLQELLAANALFlnppqcagmrikaslpnnfPVHAHVR-----TYMKYCIAAGDAYCS 618  Trypanosoma b...
EEA08301      663 tsrneqivrstniskqsiLNFAIMNDLFTRLLALlpnd------------ahpSGSISRRnlychKWYYHSILAAQAFQY 730  Cryptosporidi...
Q9BI63        479 aalnlakvssiegdhlvaVAQTLAAEQF-------------------------EKAGMGR-----KASFHRVLAANRFSN 528  Caenorhabditi...
EFO84598      485 aaatlaqvsamdgdhlvaVAQTMAAEQF-------------------------EKAGMLR-----KASFHRVLAANRFSN 534  Caenorhabditi...
CAP33307      478 aaatlsqlsaldadhlvaVAQTLAAEQY-------------------------EKSGMLR-----KASFHRVLAANRFSN 527  Caenorhabditi...
EFX86884      569 ------------------LRSAVLLEQAALCFLRsavkpnss----sgdaakpNMVPLIR-----KYAFHMILAGHRFGK 621  common water ...
EER12757      489 a----------------gLRCALLLERAARLQ---------------------RDAGQVR-----KMCFHLVLAGHTFNK 526  Perkinsus mar...
ESS31117     1138 etkelesavaasfaqsqaVRSAMLLEQAALCFEQ-------------------AGILHRR-----KRNFQLVMAGHTYYK 1193 Toxoplasma go...

XP_018652567  685 AKQPILAIRSYKSTMPIV-------------MGHGWSLLEDHIN 715  Schistosoma mansoni
EEH51492      609 AGLRANAIRCYAGALPVYerrrdagpgagkrRGVGWNKAREHLH 652  Micromonas pusilla CCMP1545
Q57ZE9        619 EDMFQSALRCYLRALFVYgs---------vgRCGSWPHICEHLF 653  Trypanosoma brucei
EEA08301      731 IGFKAISLQSFLNVLLQE-------------DTIKWPDIDTYLR 761  Cryptosporidium muris RN66
Q9BI63        529 AAIPALSFDCYRLALPAF-------------DKKHWGVLDEHLA 559  Caenorhabditis elegans
EFO84598      535 ASIPALSFDCYRLALPTF-------------DQKHWGVLDEHLA 565  Caenorhabditis remanei
CAP33307      528 AGIPALSFDCYRLALPAF-------------DQKHWGVLDEHLA 558  Caenorhabditis briggsae
EFX86884      622 SGQKRHASRAYQLALQVY-------------KGHGWSLAEDHIH 652  common water flea
EER12757      527 AGYKQWALACYKAVVPEY-------------AGKGWTHITDHLL 557  Perkinsus marinus ATCC 50983
ESS31117     1194 AGFKRLALRCYTSVVSHY-------------EWSGWQHVSQHLR 1224 Toxoplasma gondii VEG
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