Conserved Protein Domain Family
Hyccin

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pfam09790: Hyccin (this model, PSSM-Id:370695 is obsolete and has been replaced by 462903)
Hyccin
Members of this family of proteins may have a role in the beta-catenin-Tcf/Lef signaling pathway, as well as in the process of myelination of the central and peripheral nervous system. Defects in Hyccin are the cause of hypomyelination with congenital cataracts. This disorder is characterized by congenital cataracts, progressive neurologic impairment, and diffuse myelin deficiency. Affected individuals experience progressive pyramidal and cerebellar dysfunction, muscle weakness and wasting prevailing in the lower limbs.
Statistics
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PSSM-Id: 370695
Aligned: 27 rows
Threshold Bit Score: 162.941
Created: 3-May-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
ESO07683      60 YESYGESVRNDKELMDELYCLLNHTSFHkydQLLDPVCHQLFN-FYRSSVHSLHCFAIEFIPTIVGSYLSASMSSSHLH- 137 Helobdella robusta
3_pfamImport   1 LAAYAKLAHEKDAVLVSFKSAVNSFQNEslvELVQPASHQLFE-FYRSGNNDLKIHAISFFPALVGGYLLACSSKHENA- 78 
1_pfamImport   3 LNKVAPSSLFAANYISTNYTDV---------DLIQPIIGQILAiYYKSGV--LRLYALQFVPGFVSLYLLALSKKQQKS- 70 
CRZ23519      36 LTRETCKTQYLINYLSCNYTDV---------DLVQPVVAQLLAcYYRGGI--LRYFVLQCIPSLIHIYLLALAKRQKKS- 103 Brugia malayi
XP_016660375  21 wATFAITTSQNKTLIESIYAVLDDIHKYs--KLVDRICGALFN-CYRTEETDLHLFVLLFIPHLTYSYLNSIAHVDKQS- 96  pea aphid
6_pfamImport   2 LHTFASTIHLNSEVINAVFAVLEDRQKYc--ELVDPVCTILFD-FYRSKEIELKRFTLVFLPTLIYVYLNAVAHGEKKS- 77 
Q9FMI8        94 SDRPALSLLSSRAAYSLISNSLCNPASG---SGSDPLCQWLYE-TYLSSDPPLRLVVLSFFPLLVGMYLSRIHSSDSTSl 169 thale cress
ERN00949      57 SDRPAQALLEDSSLSSSLSSALSLSSSG---SGSDPLCHWLYD-TFLTSDLDLILVVLSFVPLISGLYLSR-SSSLSSSs 131 Amborella trich...
ESO07396      18 llDFAEDIKKDHTLKKEIFFFIENKNKS---EELDPVVHQLFN-FYRLDNDQLKKFSLEFIPAMLLKYY-SAINGQQVV- 91  Helobdella robusta
XP_009112116  71 SDRPALSLLSSRPAYSLISASLRDPSSG---SGSDPLCQWLYE-TYLSSDQPLRLVVLSFLPLLAGTYLSRIHSSDSSSl 146 field mustard
ESO07683     138 -----SG---CLAAFLLGVYNL-----------GNSEMTTINafpiVPSLS-----QPSVYHD-PSsv--slITRLTEAA 190 Helobdella robusta
3_pfamImport  79 -----SKikvSLGTCLLAIYNLvcee---nekeNSDQNYEIE----MPNLS-----NPSIYHD-PM------AYPFSEYT 134
1_pfamImport  71 -----VS---LFETFLTAIYNEeivkd-sergtNEKKTEDIR----IPSIR-----HHSVYHD-PAkiqiqtELPITRNA 131
CRZ23519     104 -----VS---IFETFFLAMFNEeilaggilsesVTKKVEEVR----IPSIR-----FPSVYHD-PKklslasDIALKSGA 165 Brugia malayi
XP_016660375  97 -----CR---SIEALLIGIYNLeav-----denNTPRFISFR----LPSLA-----QPSIYHE-PSsl---aPTSLTETA 150 pea aphid
6_pfamImport  78 -----CR---GVEALLVGLYNLeav-----ddnFEAQNVSFR----LPSLA-----QASLYHE-PMsl---aPLSLTERA 131
Q9FMI8       170 p---sLS---GFEAVLLAIYAAevk-----araGKPILVH------IPDLS-----QPSLYHT-PRngv-dkSRD-SNP- 223 thale cress
ERN00949     132 sprpnLA---GFEAVLLALYSSevk-----irqGKPIKVN------IPDLG-----LPSLYHA-PRqap-agSPRVPEQ- 189 Amborella trich...
ESO07396      92 -----IS---SLEAFLLGMYNLd---------sTRLKLNCQTdfllQPNSAlifntTSSIYHDiPMgv---tTSMLTRSA 151 Helobdella robusta
XP_009112116 147 p---sLS---GFEAVLLAIYAAevk-----sraGKGVLVH------IPDLS-----QPSLYHT-PRnggvdrSRDSSNH- 202 field mustard
ESO07683     191 LSVR--LNSEHvPVKRPTH-KKYDGITPQNRSAILSFVISVYNMNITLMSFR--SRKSLCHLSSK----LSRTGFEDyve 261 Helobdella robusta
3_pfamImport 135 VNSS--NHGRT-FVKLPPM-KSYLNIYPENRSEIMDVIMSCYADYVAIIPTT--SLIQVCDMCLQ----IVSQAFPW--- 201
1_pfamImport 132 SVTP-----VLhTVHFGPF-PSVSKMNGENRFTVLNRILFSVNESLFEVASEi-AARYVCLGTLS----VCRSGFSFpet 200
CRZ23519     166 PAFV----QATkTVRIGPY-KSVDRIFPQNRQTVLTRLLKSVNGCLCRLSRDv-ICQGICLSTIA----LCQSGFSFret 235 Brugia malayi
XP_016660375 151 IRRL--EQRDThPVRRGPF-NQIERLSASNRMEVLSNLYFIYYKNLNLLPEVynPFDRFYRVTSK----MVTQGYFHkr- 222 pea aphid
6_pfamImport 132 LRRL--EECNTkLVRWGPL-TQVEKIIAQNRLVVMTALLFIYNQHISCLQKY--SLDQLCKVVSK----LVTQGF-Nkpg 201
Q9FMI8       224 --------TASvGVLSPQLePQI-AVKSTKRASIVGVGLQCYFKEISQMPAW--SKLEFCKFSAswagqdCDCKEKIded 292 thale cress
ERN00949     190 ------------GVVSPPLePQT-AVKSTKRASIVGVALDLFYRKIAVMPMR--SKLDLCNFAAswagqnCPCCHQLddl 254 Amborella trich...
ESO07396     152 LDRWhvHNSHQsKIKNVTYlKATDSVTNKNKLTIMIHALQRYNEHISDFSDL--SHLTLCKFCM---------MFTKtk- 219 Helobdella robusta
XP_009112116 203 --------VASvGVLSPQLePQV-AVKSTKRAGIVGVGMQCYFKEISQMPAW--SKLELCSFAGawagqdCDCKEKIdge 271 field mustard
ESO07683     262 clspia--------nqhcstsgDNGSWQKDPESMHQ-------------------------------------------- 289 Helobdella robusta
3_pfamImport 202 ----------------------HSNFLKVERTNDIR-------------------------------------------- 215
1_pfamImport 201 gfr-------------skvlesESPREVIEDFSRKP-------------------------------------------- 223
CRZ23519     236 alv-------------srvfgsSFHHKEFDDFSKKP-------------------------------------------- 258 Brugia malayi
XP_016660375 223 --------------------stSFTNSDISTSTTLP-------------------------------------------- 238 pea aphid
6_pfamImport 202 krv----------------------syssdVPRVLP-------------------------------------------- 215
Q9FMI8       293 edkvl----------altngfgD-SSSFNGSSG-RSleieedfdrlairene----------------------eqlssn 338 thale cress
ERN00949     255 nvgslqiamenldlqnhnnsepSPSSPRSSSSSLSSrsvvqeeedgpsakirvsleendhgqypeirappsreegeeiri 334 Amborella trich...
ESO07396     220 --------------------kdNPNVESQADNNIMP-------------------------------------------- 235 Helobdella robusta
XP_009112116 272 gdkvl----------altngfvDSSSSLNGSSEIEAeeveeeeeeqvis-----------------------------sn 312 field mustard
ESO07683     290 ----------KIPFDESLIIEILVGIYYLMFNGLSKLCMQAVDDIHLRASYDLNYPVLLVTNAFLNSLHLNNTSPdlSQE 359 Helobdella robusta
3_pfamImport 216 ----------RVQITSSVMLSILRSVYFALYNGCRSYAISAIEAAKMRGCYEMCPKVQLFCNAVLNSTLQEDDQN--LGN 283
1_pfamImport 224 ----------RQKVTAEFLNHLLRGCYLALFNGAADLALRAIDSIHMRAQYEMLPETLLVVNSLRNSLLDNMWSK----- 288
CRZ23519     259 ----------RLRISSQYLLESLNGLYFALFNGTPELAVQAVDAVHQRALYEFYADVILVTNSISETLLESNFHK----- 323 Brugia malayi
XP_016660375 239 ----------RIPLSPKFLIHLLYCLYISIFNCGKAEAFQALEDIYYRACYSCYCEVILLANAIKNSCQGSFEG----GQ 304 pea aphid
6_pfamImport 216 ----------RIPVSQKFLLEVLYSLYYSIFNGDVILALQAVEEVHQRACYQGYSDVMLVTNAIKNATPPAHSGQ--ITD 283
Q9FMI8       339 gggggvgrgvRIPLPWELFQPTLRILGHCLL------------------------------------------------- 369 thale cress
ERN00949     335 reearvssegRIPLPWELLQPVLRILGHCLL------------------------------------------------- 365 Amborella trich...
ESO07396     236 ----------KH-------------------NGQSEAGLMAVSSLYKRAHYDLLPASIMSIGALMSFISNAQNDEddDNN 286 Helobdella robusta
XP_009112116 313 gvgvgvgggvRIPLPWELLQPILRILGHCLL------------------------------------------------- 343 field mustard
ESO07683     360 DSKSLSVTASPIQT--------------------------HRHskFP-KDAITNASFRTRKLPD 396 Helobdella robusta
3_pfamImport 284 SPLGLPTLLTPILS--------------------------RSSssVS-RHAVTAKSIKDHKWKH 320
1_pfamImport 289 ---EKRGELMWTRP--------------------------QHKdmIRrKDLVTNASLKMKRMPE 323
CRZ23519     324 ---NEELTAQWVRP--------------------------GKLdnHKrNEVVTNASLRLKKMPE 358 Brugia malayi
XP_016660375 305 TPNVSSVGTPVSSN--------------------------TCStpVS-KSMITNASFRTKKLPD 341 pea aphid
6_pfamImport 284 NPMGISLAISPSTA--------------------------PTV--VS-KSMITNASFRTKKLPD 318
Q9FMI8       370 ------------------------------------------------------SPLNTEDVKD 379 thale cress
ERN00949     366 ------------------------------------------------------APLNPQEVRD 375 Amborella trichopoda
ESO07396     287 GDNAATTTTTTTTSqlkkllprhlqqhdaqqkflsqqqsqQQQqqLT-REAITNATFRTQTMPE 349 Helobdella robusta
XP_009112116 344 ------------------------------------------------------SPLNSEDVKD 353 field mustard
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