3VH5,3V9R


Conserved Protein Domain Family
CENP-X
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pfam09415: CENP-X (this model, PSSM-Id:370474 is obsolete and has been replaced by 462793)
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CENP-S associating Centromere protein X
The centromere, essential for faithful chromosome segregation during mitosis, has a network of constitutive centromere-associated (CCAN) proteins associating with it during mitosis. So far in vertebrates at least 15 centromere proteins have been identified, which are divided into several subclasses based on functional and biochemical analyses. These provide a platform for the formation of a functional kinetochore during mitosis. CENP-S is one that does not associate with the CENP-H-containing complex but rather interacts with CENP-X to form a stable assembly of outer kinetochore proteins that functions downstream of other components of the CCAN. This complex may directly allow efficient and stable formation of the outer kinetochore on the CCAN platform.
Links
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Statistics
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PSSM-Id: 370474
Aligned: 87 rows
Threshold Bit Score: 46.3583
Created: 3-May-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3VH5_D                     11 KETVERLLRL-H-FRD-GR---TRVNGDALLLMAELLKVFVREAAARAARqAQAEDL----------------EK----- 63  ch...
ESX02858                   10 ATTIARLFHTvA-FDD-KS---IKISHKTLLLVSEYIKLFTSEAIVRSNVeRLEEGK----------------RDkeryr 68  Og...
Q6BJ85                     17 IATIARLFQTsA-FKN-EK---TRITQKTLQLSSEYIKLFINEALIRSNEeRLAEG------------------------ 67  De...
EGW33714                   11 VATIARIFRElS-FKN-DS---TRITMDTLELSSEYIKLFINEAIIRSNQeRLDEG------------------------ 61  Sp...
WGS:AACQ:CAALFM_CR10180WA  20 VTTIARLFKElS-FKD-PQ---TRITLSTLELSSEYIKLFINEAIIRANEeRIDEG------------------------ 70  Ca...
LoveMIT:GQ68_04122T0        8 KTTLARLFHTvA-FEE-PD---TRISSKTLELSIEYLKIFTKEAVIRADEvRRDRNG----------------QVrskyn 66  Ko...
EGG05239                   22 twtadRLSSLeA-TSE-PP---PKINDAALHLSVEYLRLFTIELIHRANEaAGGSED----------------KGnskdk 80  Me...
NP_001077843               12 ihaifkhIWArR-FRErERsdaIDATEAEVALGTTKKNRLASEAVQRAAIiAEAEGM----------------EK----- 69  th...
Q20071                      7 QSTVRSMLIVaR-RGK-KR---LNLDPDALAVLTALINLLAQESVARAAQsAANTGS----------------RH----- 60  Ca...
XP_011273965               11 iTTLSRLFQT-AvFEH-ED---SKITQQTLELSSEYLKMFIREAILRANDvRENPKDainkgdsdalqnqligDV----- 80  Wi...

3VH5_D                     64 --------------------VDI--EHVEKVLPQLLLD-F 80  chicken
ESX02858                   69 vdvde-----hldekqqdavLDT--RHLEAVAGLLTLD-F 100 Ogataea parapolymorpha DL-1
Q6BJ85                     68 -------------------------DTLTKVDGIDNLNkT 82  Debaryomyces hansenii
EGW33714                   62 -------------------------DSLTKVDGIDNVN-Q 75  Spathaspora passalidarum NRRL Y-27907
WGS:AACQ:CAALFM_CR10180WA  71 -------------------------DTLVQIDGIDNVT-S 84  Candida albicans SC5314
LoveMIT:GQ68_04122T0       67 iklenvedqpientdsnggiLDV--NHLSQISGSLILD-F 103 Komagataella phaffii GS115
EGG05239                   81 de------------tdseylIEV--RHLQKVAPGVLLD-F 105 Melampsora larici-populina 98AG31
NP_001077843               70 --------------------IEA--THLERILPQLLLD-F 86  thale cress
Q20071                     61 ----------------------VtkEHLKRVIAQLMLD-F 77  Caenorhabditis elegans
XP_011273965               81 --------------------LDA--QHLEEIAGLLVLD-F 97  Wickerhamomyces ciferrii
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