Conserved Protein Domain Family
GIT_SHD
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pfam08518: GIT_SHD (this model, PSSM-Id:369921 is obsolete and has been replaced by 462506)
Spa2 homology domain (SHD) of GIT
GIT proteins are signaling integrators with GTPase-activating function which may be involved in the organisation of the cytoskeletal matrix assembled at active zones (CAZ). The function of the CAZ might be to define sites of neurotransmitter release. Mutations in the Spa2 homology domain (SHD) domain of GIT1 described here interfere with the association of GIT1 with Piccolo, beta-PIX, and focal adhesion kinase.
Links
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Statistics
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PSSM-Id: 369921
Aligned: 62 rows
Threshold Bit Score: 42.3874
Created: 3-May-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EIE85587      16 ARQKLTRLSNSQFHELAMDVYDEVVRRTK 44   Rhizopus delemar RA 99-880
EEB14727     317 GRQKLGRLTEKEFNVLIFDILQEIKRRDT 345  human body louse
EFA09439     319 GRQKLARFSTPELKSLVFDILIDTQRRQL 347  red flour beetle
EFX84315     338 ARQKLGRLNAREFATLLIDLLSEAKRRQQ 366  common water flea
EDO44131     328 GRQKLALFNAQELTTLIIDILNEARRREQ 356  starlet sea anemone
XP_001944772 315 GRQKLACYGQKEFKKLVTQILIEINRRTQ 343  pea aphid
ROT69302     460 GRQKLARFNAREFATLIIDVLSDAKRRQt 488  Pacific white shrimp
XP_013770160 332 GRQKLARFNAHEFATLVIDILSEAKRRQQ 360  Pundamilia nyererei
XP_025016552 342 GRQKLARFSAKNFTSLLIDVLIESKRRQL 370  two-spotted spider mite
XP_028038181 325 GRQKLARLSPRELAALLRDVLLDATRRQR 353  wild silkworm
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