Conserved Protein Domain Family
DEXXQc_Helz-like

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cd18038: DEXXQc_Helz-like 
DEXXQ/H-box helicase domain of Helz-like helicase
This subfamily contains HELZ, Mov10L1, and similar proteins. Helicase with zinc finger (HELZ) acts as a helicase that plays a role in RNA metabolism during development. Moloney leukemia virus 10-like protein 1 (Mov10L1) binds Piwi-interacting RNA (piRNA) precursors to initiate piRNA processing. All are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Statistics
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PSSM-Id: 350796
Aligned: 29 rows
Threshold Bit Score: 247.918
Created: 20-Jul-2011
Updated: 17-Oct-2022
Structure
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Aligned Rows:
 
ATP bindingDEAD box
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Comment:based on the structures of other Upf1-like helicase family members with bound ATP or ATP analogs
  • Comment:Walker A motif or motif I

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1              #                               ######                                     
Q99MV5        746 VLNENQKLAVRRILSgd--------crPLPYILFGPPGTGKTVTIIEAVLQVHYalp----------dsRILVCAPSNSA 807  house mouse
P42694        641 RLNAKQKEAVLAITTpla-------iqLPPVLIIGPYGTGKTFTLAQAVKHILQqq-----------etRILICTHSNSA 702  human
XP_417438     752 IGNSKQKLAISFIAGqats-----rrqVPPLLIYGPFGTGKTFTLAMATLEVIRqp-----------ntRVLICTHTNSA 815  chicken
XP_002297153  413 VENSDVSKPLNELQSsf--------vrMPPMVLSGPAGTGKTKTLMAAIADVLGllqpaqs--ielntnRVLVCAPSHAA 482  Thalassiosira...
ABO98305       13 VLNDEQLRVVEDVVSga--------gkQYPYIVWGPPGTGKTLTIVECVAHVLEmfp----------haRVLLAAPSAFA 74   Ostreococcus ...
CAZ80836      391 ELNYEQQKAVDTILQqn--------ygNVPYLISGPPGTGKTKTIVEVALQLIFtpsn--------pkhHILLCAPSQEA 454  Tuber melanos...
EFI93493      175 GLNEEQKIAASSIAThq---------fSVPYLISGPPGTGKTRTLVECVLQILRlqp----------eaCILLCAPSNPA 235  Schizophyllum...
CBJ30823      753 STNDSQRTAVRDIVTga--------hgQVPYIIFGPPGTGKTCTVIESILQLVKlrp----------ecRILAVGPSDTS 814  Ectocarpus si...
EGD73907      680 RVNQEQQLAVRAVLTrsrrlvsgsvkdLPPLVIHGPPGTGKTLTLVECIRQLLLdydmrshkrrkhrkpRILAVAPSNTA 759  Salpingoeca s...
XP_002670656  446 VEKYEKVDISFRFSRtpik-----lmhRALSMFFGPPGTGKTFVVSQCILEIMKqdp----------nhKILICAPSNQA 510  Naegleria gru...
Feature 1                                                                                         
Q99MV5        808 ADLVCLRLHESkvp---kpaAMVRVNATcrfeetiidaikp---------ycrdgediwrasrFRIIITTCSSAGLFYqi 875  house mouse
P42694        703 ADLYIKDYLHPyveagnpqaRPLRVYFRnrwvktvhpvvhqycli-ssahstfqmpqkedilkHRVVVVTLNTSQYLCql 781  human
XP_417438     816 ADIYIREYFHKyvtnghpwaVPLRIIATdrpinltdpttqmyccl-tkdqrsfrhptreeidkHPIIITTSMLSKHLKva 894  chicken
XP_002297153  483 CDVITRRLSVFlk-----rtEIFRMYDSarps---------------------------ntvpGDIVPFTCQLPKSDRqc 530  Thalassiosira...
ABO98305       75 ADILCSRLAKRltpf--kkkMIVRVNDVrrtpesyasvpfh---------ffkrpdplkhlkhARVVVCTCTSAALLRkl 143  Ostreococcus ...
CAZ80836      455 ADTLALRLVPYln-----prVLFRLQSStrtfpevpsellpysh---iandmfslpewkklmgFRVVVCSTRDAEILVea 526  Tuber melanos...
EFI93493      236 TDTLVMRLRHFlk-----psEMLRLNDQyrtfaevpveifsycr---ienekfaippwpelmkFRVVVTTCYDASILVna 307  Schizophyllum...
CBJ30823      815 ADVICERLSRHms-----rdQLVRINWWqrltagvhpnilsycp----qdsnrgmfvppstitHQVVVCTCGTAGMLSvl 885  Ectocarpus si...
EGD73907      760 ADIIVDRLSNTeaay--pstNILRVNWYqrdqasmdprlsatfavpsacsagyelpsaerlkqARVVVCTCDIVGHLShi 837  Salpingoeca s...
XP_002670656  511 ADIIVERLVDSnln---plvKMMRMNSVqrdpntftkrwiikfsn--kldqgfeipelheiakYDVIISTCTSSGYLYsk 585  Naegleria gru...
Feature 1                                                                                         
Q99MV5        876 gvr---------------------------------------vgyfTHVFVDEAGQASEPEcliplg------------- 903  house mouse
P42694        782 dle---------------------------------------pgffTHILLDEAAQAMECEtimpla------------- 809  human
XP_417438     895 p------------------------------------------gyfTHIMIDEAAQMLECEalipls------------- 919  chicken
XP_002297153  531 frsflllksnnlg------------------taasgpfeymdnpffSHLFIDEAAQATEPEilcplscvv---------- 582  Thalassiosira...
ABO98305      144 pmpvds---------------------------------vvenwtpTHIFVDEAAQALVPEtlipls------------- 177  Ostreococcus ...
CAZ80836      527 rctnkdlarweksvfdslrgigdesdgndptasgvvekgqivnvhwTALLLDEAAQGIEPEvavavsvvv---------p 597  Tuber melanos...
EFI93493      308 qctntalaklehyvm--------------salhptkevsrgvvphwTHLLIDEAAQGSEPEllipisvvvprqqdhpdik 373  Schizophyllum...
CBJ30823      886 gvd---------------------------------------enyfTHIFVDESSNAMETEllvpl-------------- 912  Ectocarpus si...
EGD73907      838 tgdah-----------------------------------pmqgffTDILFDEAAQAMEPEawivlr------------- 869  Salpingoeca s...
XP_002670656  586 gvk---------------------------------------pghfSHIIIDESGESVIPEalipfs------------- 613  Naegleria gru...
Feature 1                           #                                                           ##
Q99MV5        904 --lisdinGQIVLAGDPMQLGPViksrlamayGLNVSMLERLMsrpaylrden------afgacgaynpLLVTKLVKNYR 975  house mouse
P42694        810 ---latqnTRIVLAGDHMQLSPFvysefarerNLHVSLLDRLYehyp-------------------aefPCRILLCENYR 867  human
XP_417438     920 ---yatfeTRIVLAGDHMQITPKlfcv-adgqSAYHTLLNRLFqfyqke--------------khevamKSRIIFNENYR 981  chicken
XP_002297153  583 dpypggklVEVGFIGDPRQLSPQifsdesakyGLGRSFMERLLrrpvec--------------mggqdeSLTIFLTENYR 648  Thalassiosira...
ABO98305      178 ---lasseTSIVLAGDSKQLGPNvhskeaaqaGLRKSLLEMWMdhskee---------------vargvWNGTQLRACYR 239  Ostreococcus ...
CAZ80836      598 peeasvdrPIFVMAGDQRQLGPRtvs---rvpQLDMSLFERLFlrely-----------------sqhpLARQSFTHAYK 657  Tuber melanos...
EFI93493      374 pesnflftPQLVLCGDCHQLGPIvassrarssELDVSLLERLFlrplya--------------ehplsrGELDFLKKNYR 439  Schizophyllum...
CBJ30823      913 ---syagrAQIILCGDPRQLGAAvrspaaralGLEVSLQERLMeqemyskhaqaptalssatsngaadvRCMTQLLNNYR 989  Ectocarpus si...
EGD73907      870 ---lasaaTNVVVAGDHCQLGPLvrspeadrgGLGKSWQERLLelpaya---------------dctnpLFKTTLLRNFR 931  Salpingoeca s...
XP_002670656  614 ---lkgdnTVVVLAGDPKQLGPIvrsplaveyGLGESLLEHLVklg--------------------dncCSITQLQQSYR 670  Naegleria gru...

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