1W36,3E1S,5LD2,3UPU,5N8O,5FTF,5FHH,5FTB,5FHD


Conserved Protein Domain Family
DEXSc_RecD-like
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cd17933: DEXSc_RecD-like 
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DEXS-box helicase domain of RecD and similar proteins
RecD is a member of the RecBCD (EC 3.1.11.5, Exonuclease V) complex. It is the alpha chain of the complex and functions as a 3'-5' helicase. The RecBCD enzyme is both a helicase that unwinds, or separates the strands of DNA, and a nuclease that makes single-stranded nicks in DNA. RecD is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Links
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Statistics
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PSSM-Id: 350691
Aligned: 89 rows
Threshold Bit Score: 114.959
Created: 20-Jul-2011
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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ATP bindingDEAD box
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          #                        ########                                              
1W36_D        153 WQKVAAAVal-------tRRISVISGGPGTGKTTTVAKLLAaliqmadgercrIRLAAPTGKAAARLteslgkalrqlp- 224  Escherichia c...
5FHH_A         11 EQAAVLRAvl-------kGQSIFFTGSAGTGKSYLLKRILGslp------ptgTVATASTGVAACHI------------- 64   human
AAS20177      172 LQLNAAQQslvrematsgRAVQLALAPAGTGKTTAMQVLTRawqd----sggtVIGLAPSAVAAQELgasinlenpdtnt 247  Arthrobacter ...
YP_001096262  588 AKMAHSLLvt-------gEKLACAVGPAGTGKTASMAVVADawkn----eghkVLGLAPSARAAQQLgqd---------- 646  Corynebacteri...
YP_001740104  481 AQKHAAQIva------sgCGLGVVEGAAGSGKTTMLREAKKllda----egrqLVVLAPTLKGAQEAars---------- 540  Arthrobacter ...
NP_776232     451 DQAEAMRAvvs-----srYLASVVIAPAGAGKTSSLKAARAaweq----agkqVVGLAPTGKAADVMvged--------- 512  Corynebacteri...
P55418        385 EQKTAIEHva------gaERIAAVIGRAGAGKTTMMKAAREawea----agyrVVGGALAGKAAEGLeke---------- 444  Sinorhizobium...
YP_220461     579 EQRAAVTRvlt-----agHGIDAIVGVAGAGKSTLMEACRIgwda----tgttYAGATLAAVAAKNLtda---------- 639  Streptomyces ...
EDZ39038      439 EQHNAINHltt-----raGRIQILEGHAGAGKSTALVPVRYales----qgfeVVGCSLQGKKAAGLqkd---------- 499  Leptospirillu...
EDZ40407      423 EQKTMVRSit------heTSLVAVQGWAGTGKSTALKAALEiwek----ngfrVRGAALSGKAALGLseg---------- 482  Leptospirillu...

Feature 1                                                                                   #     
1W36_D        225 --------ltdeqkkripeDASTLHRLLGaqpgsqrlr----------------------hhagnplhlDVLVVDEASMI 274  Escherichia c...
5FHH_A         65 -------------------GGTTLHAFAGigsgqaplaqcval-------------aqrpgvrqgwlncQRLVIDEISMV 112  human
AAS20177      248 agtsknllngpwrpgrkkvRADTLAKLVWhakhgdapa-----------------------wmekinskTLVLIDEAGMA 304  Arthrobacter ...
YP_001096262  647 ----------------aniTAQTLAALTYrwrgvigdsprd-----------------innlgveinagDMLLVDEAGMA 693  Corynebacteri...
YP_001740104  541 ----------------leaAAFSVHKLLHangfrwdengrytrlkpgetdpntgkmyrgpqgdyrltkeARVVVDEAGML 604  Arthrobacter ...
NP_776232     513 ----------------vahSSSTLARVLRrvedqdveqa---------------------vatlgwstdHVIVVDEAGMV 555  Corynebacteri...
P55418        445 ----------------agiASRTLSSWELrwnegr----------------------------kqlddkTIFVLDEAGMV 480  Sinorhizobium...
YP_220461     640 ----------------sgiPARTVAAWLGeiengn-----------------------------glrgiDVLVVDEATMV 674  Streptomyces ...
EDZ39038      500 ----------------tgiRSQTIASLLRelqgferedgg------------------kvpptktltekTVVVVDEAAMN 545  Leptospirillu...
EDZ40407      483 ----------------sgiVSKTLAALEReigedgi---------------------------lpltshDILVVDEAGMV 519  Leptospirillu...

Feature 1                                           #                                             
1W36_D        275 DlPMMSRLIDAlp---------dhARVIFLGDRDQLASVeagavlgdicayanagftaerarqlsrltgthvpagtgtea 345  Escherichia c...
5FHH_A        113 EaDLFDKLEAVaravrqqnkpfggIQLIICGDFLQLPPVtkgsqpprfcf-------------------------qsksw 167  human
AAS20177      305 AtTDLAAAIDYits--------rgGQVRLVGDDRQLASVaaggvlr---------------------------------d 343  Arthrobacter ...
YP_001096262  694 TtADLAALTEIade--------tgAVIRLVGDPHQLDAVetgglfr---------------------------------t 732  Corynebacteri...
YP_001740104  605 DqDTALALTQLadq--------ygAGLVLMGDRAQLPAVgrggvld--------------------------------ha 644  Arthrobacter ...
NP_776232     556 StPEMVRVLELaha--------adARVVLVGDPYQYGAVkargglla-------------------------------tl 596  Corynebacteri...
P55418        481 SsRQMALFVETatk--------agAKLVLVGDPEQLQPIeagaafr---------------------------------a 519  Sinorhizobium...
YP_220461     675 DdRAAAVLVTEaar--------tgTKVVGIGDHLQLQAIgpggwfr---------------------------------e 713  Streptomyces ...
EDZ39038      546 DtRLMAGLIREtek--------agVRLILVGDESQVPPVaagnpfk---------------------------------t 584  Leptospirillu...
EDZ40407      520 GsRTMERILSKvhe--------sgAKLVLVGDVRQLPAIeagaafr---------------------------------a 558  Leptospirillu...

Feature 1                       
1W36_D        346 aslrdSLCLLQKSY 359  Escherichia coli K12
5FHH_A        168 krcvpVTLELTKVW 181  human
AAS20177      344 iahqiGAVTLSEVH 357  Arthrobacter aurescens
YP_001096262  733 lvrqsNAVELDTVM 746  Corynebacterium sp. L2-79-05
YP_001740104  645 akiavERADIDVVH 658  Arthrobacter sp. Chr15
NP_776232     597 ahevpDAVELREVF 610  Corynebacterium glutamicum
P55418        520 iadriGYAELETIY 533  Sinorhizobium fredii
YP_220461     714 vhrlvHGLTLTENR 727  Streptomyces sp. F11
EDZ39038      585 lkkelGCAELTENR 598  Leptospirillum sp. Group II '5-way CG'
EDZ40407      559 ilervGSSELSHIR 572  Leptospirillum sp. Group II '5-way CG'

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