Conserved Protein Domain Family
GPN3

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cd17872: GPN3 
GPN-loop GTPase 3
GPN-loop GTPase 3 (GPN3) is a small GTPase that is required for nuclear targeting of RNA polymerase II. It forms heterodimers with GPN1.
Statistics
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PSSM-Id: 349781
Aligned: 39 rows
Threshold Bit Score: 250.908
Created: 7-Aug-2017
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative active
Feature 1:putative active site [active site]
Evidence:
  • Comment:contains P-loop characteristic for ATP/GTP-binding proteins
  • Comment:based on homology to other members of the family

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1               ########                                                                 
EAW97914      73 YAQLVMGPAGSGKSTYCATMVQHCEaln----rsVQVVNLDPAAEHFNYsvmADIRELIEVDDVMEddslrFGPNGGLVF 148 human
CBH09749       4 YAVVVIGPAGSGKSTLCCTIAEHYAtkg----rsTHICNFDPAAEELRYspsIDVRDLISLEDAMEgk--gLGPNGGLVF 77  Trypanosoma bru...
XP_652636      4 CCQLIMGPAGSGKSTYCKYMKQYLEdlh----rkPFMVNLDPAIDESYYdidIDIRDLITVEDVMSel--hYGPNGALVY 77  Entamoeba histo...
EGG22743       4 HAQLVMGPAGSGKSTYCDAMRKYCEeik----rvVHVVNLDPAAEVFEYpvsVDIKNLITVDEVMEel--eYGPNGGLVY 77  Dictyostelium f...
XP_003079131  31 YAQLVVGPAGSGKSTYCHNVHQHCAslg----rtLSVINLDPAADEFRYpvtADVRELISLEDVMEee--eLGPNGALMF 104 Ostreococcus tauri
XP_002294773   5 AIQLVTGPAGSGKSTYCHILQEHCLtlsprhrrrVHVINLDPAAEHFRYqvsLDIRDLISVDDVMDel--qLGPNGSLVY 82  Thalassiosira p...
NP_499587      3 YAQLVMGPAGSGKSTYCSVMYNHCLstg----rtLRMVNLDPACEVFNYpavVDVRDLISVNDVQEdeeliLGPNGALVF 78  nematode
EFX70457       3 YAQIVIGPAGSGKSTYCTEMQRHAEtsr----rnIHIVNLDPAAESFEYkpsIDIRDLIHVDDAMEdeemhFGPNGALVF 78  common water flea
CCA21276       3 CCQLVMGPAGTGKSTYCNNIQEFCAasg----rmTYVVNLDPAAEQFEYpvaFDIRDLISVEDVMEel--gYGPNGGLVY 76  Albugo laibachi...
XP_001713535   3 NGLFIIGPAGSGKTSFCNELKKTIIsqr----ksVAIINLDPASEKLIYepeIDIKNLIKCYEVGEel--gLGPNGSLLF 76  Guillardia theta
Feature 1                                                                                        
EAW97914     149 CMEYFann-fdWLENCLGHVEd-DYILFDCPGQIELYTHLpVMKQLVQQLEqwe--frvCGVFLVDsqfmv-esfkFISG 223 human
CBH09749      78 CMEYLlsageqWICEQLGDHAe-DFIIIDMPGQVEVLSHVpAVPNFVRLLQrvg--ynvVVLFLLDalaatvdagkFVSG 154 Trypanosoma bru...
XP_652636     78 CLEYFldn-ieWFEEQLGDYDd-DYLIIDCPGQIELYSHLpVMSRFVDFMKren--yfmCGVFLVDsqvlt-dsakYVSA 152 Entamoeba histo...
EGG22743      78 AMEYLien-mdWFTDEIGDYDe-DYLIIDCPGQIELYSHIpVMRTLVETLKqng--ynvCAVFLVDsqfil-dsckFISG 152 Dictyostelium f...
XP_003079131 105 CMEYLednmddWLAEQLEGYMedDMVIFDCPGQLELYSHHsAFKSMTEKMTgwg--wkmVCVYILDaqfis-dgtkFIAG 181 Ostreococcus tauri
XP_002294773  83 CMEYLlen-mdWLQDNLEEYDedEYLIIDCPGQIELYTHIpVMNKIIDQLRtwgygesmVSVFVVDatfit-daakFISG 160 Thalassiosira p...
NP_499587     79 CMEYLvqn-leWLHDELDEGEd-DYFVIDCPGQIELYSHLpVMRQIVDALKswd--fnvCSVFLIDtnfvl-daekFISG 153 nematode
EFX70457      79 CMEFLlen-lpWLENQLGEDDd-DYFIFDCPGQIELYTHLnVMKKLLEALElwn--frlCAVFILDshfmi-nassFISA 153 common water flea
CCA21276      77 CMEYLiqn-ldWLENLLTEYSddDYFIFDCPGQIELYSHLpVMKNLCEALQcwg--faiCGVYLIDslfia-dankFISG 152 Albugo laibachi...
XP_001713535  77 CMEYLldn-lnWLIKEISFFRntNFLIFDFPGQIEIIMNNsYMNDLIYELEkkle-islLKFFLLDaqfis-diskYIGG 153 Guillardia theta
Feature 1                           ## ##                                                        
EAW97914     224 ILAALSAMISleipQVNIMTKMDLlskkakkeiekfldpdmyslledst---sdlrskkfkkltkaicgliddysmVRFL 300 human
CBH09749     155 CTFALSSMVCfdcpFMTVLTKCDLlppdvkegdlehycycnfdhvnl------kplqgrwqemvrtmasvihdfnlVSFR 228 Trypanosoma bru...
XP_652636    153 VLCCLSVMTSleipHLNVLSKMDLwsknmqntetfydflendplftssl---deqvgdryhnlnvalvelvqsyslVGFS 229 Entamoeba histo...
EGG22743     153 SLMCLSAMIRlevpHINVLTKVDIikrsqqikdiesflemevpdiverl---dsethnryhklnraigklledyslVSFL 229 Dictyostelium f...
XP_003079131 182 CLQAQSAMLHlalpHVNILSKVDMlqdksvlepylcpdhqrlaneld------ermdpkyrklnhaiasvmedfalISFA 255 Ostreococcus tauri
XP_002294773 161 SLLALSAMISmqlpHVNVLSKCDLveeasslarerrwnr-----------------------ltesicsllddfsmVGFI 217 Thalassiosira p...
NP_499587    154 ALTALSAMVAietpAINVLTKMDLlsernkqlvdefletdtrsivdqd----etvwnskhrkltrtiaqvledysiVKFV 229 nematode
EFX70457     154 SMAALSAMTTlevtFISILSKIDLlskkskkqlerflepdvkdicandtavvnskwnqkhqmltemigrvledyslIKFA 233 common water flea
CCA21276     153 VLCSLSAMVQlelpHINVLTKCDLvdekelekyknkyldpssdrlietl---vsntgakwrslntaicnvindysmVAFV 229 Albugo laibachi...
XP_001713535 154 ILTSFICMIIndqtQYNILSKANYvknfpkeiinkylnpcmsdfffel----niihgksykklnfsvlklledfsfMKFI 229 Guillardia theta
Feature 1          ###              
EAW97914     301 PYDQSdeESMNIVLQHIDF 319 human
CBH09749     229 PMDITdtAYVSNICQQMDE 247 Trypanosoma brucei gambiense DAL972
XP_652636    230 PLNIKneETIDVLLQKIDT 248 Entamoeba histolytica HM-1:IMSS
EGG22743     230 PLDITdqESLNVLLQHIDN 248 Dictyostelium fasciculatum
XP_003079131 256 PLDISdeESLQFVLYQCDC 274 Ostreococcus tauri
XP_002294773 218 PLNINdeDSIAHVLATVDH 236 Thalassiosira pseudonana CCMP1335
NP_499587    230 PLNCEdeESIDQLLLTIDT 248 nematode
EFX70457     234 PLNITdeDNLANILFMVDN 252 common water flea
CCA21276     230 PMNITkeDSIANVLMHVDH 248 Albugo laibachii Nc14
XP_001713535 230 PLEITnvNYLVNIYKLLVN 248 Guillardia theta

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