Conserved Protein Domain Family
BTB_POZ_ZBTB7B_ZBTB15

?
cd18327: BTB_POZ_ZBTB7B_ZBTB15 
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B)
ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.
Statistics
?
PSSM-Id: 349636
Aligned: 6 rows
Threshold Bit Score: 212.013
Created: 12-Sep-2017
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
O15156         9 IGIPFPDHSSELLSCLNEQRQLGhLCDLTIRTQGLEYRTHRAVLAACSHYFKKLFTeggggavmgag-gsgtatggagaG 87  human
NP_001079031   9 IGIPFPEHSSDLLSSLNEQRHSGvLCDITIKTRGLEYPTHRAVLAACSDYFRKMFTgmpgr--------------gkcpD 74  African clawed ...
XP_006002211   9 IGIPFPEHSNELLSSLNEQRHKGlLCDVTIKTRGLEYRTHRAVLAACSQYFKKLFTcgtm---------------agqqD 73  coelacanth
KPP79234       9 IGIPFPEHSNELLSCLNAQRRAGlLCDLTLTSRGARYSTHRSVMAAVSLYFRKLFGaeegesgd--------lgagggcS 80  Asian bonytongue
KQK76079      10 IGIPFPEHSSELLSCLNEQRQMGlLCDVTIKTQGLEYRTHRAVLAASSRYFKKLFAgpg-----------------pgqE 72  blue-fronted am...
AGN91186      10 IGIPFPQHSSELLRGLNEQRRRGlLCDLTLVTQGLEYRTHRSVLAACSLYFRRLFGgggggggggggggggrggvgghrN 89  elephant shark
O15156        88 VCELDFVgPEALGALLEFAYTATLTTSsaNMPAVLQAARLLEIPCVIAACMEILQ 142 human
NP_001079031  75 VCQLDFLkPDALGALLDFAYTATLTISngNMRDVLRAARLLEIPCVVHACVDILQ 129 African clawed frog
XP_006002211  74 VCELDFVePEVMGALLEFAYTATLTISssNMREMLHAAQMLEIQCVMDACADILR 128 coelacanth
KPP79234      81 VCQLDCVaPDALGALLEFAYTATLTIRssGMREVLKAAQLLGIQCVADACRDILG 135 Asian bonytongue
KQK76079      73 VCELDFVgPEALGALLEFAYTATLTISsaNMGEVLRAARLLEIPCVIAACVEILQ 127 blue-fronted amazon
AGN91186      90 VCELDFVpPEVLSALLEFAYTATLTISssNMREVLRASRVLEIGCVAQACADILG 144 elephant shark
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap