Conserved Protein Domain Family
BTB_POZ_ZBTB25_ZNF46_KUP
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cd18213: BTB_POZ_ZBTB25_ZNF46_KUP 
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25)
ZBTB25, also called zinc finger protein 46 (ZNF46) or zinc finger protein KUP, is a transcription repressor that facilitates viral RNA transcription and replication. It interacts with viral RNA-dependent RNA polymerase (RdRp) proteins and modulates their transcription activity. It also functions as a viral RNA-binding protein, binding preferentially to the U-rich sequence within 5' UTR of vRNA. ZBTB25 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.
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Statistics
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PSSM-Id: 349522
Aligned: 5 rows
Threshold Bit Score: 255.975
Created: 13-Sep-2017
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
P24278          3 TASHSLVLLQQLNMQREFGFLCDCTVAIGDVYFKAHRAVLAAFSNYFKMIFIHQTSECIKIQPTDIQPDIFSYLLHIMYT 82   human
NP_001087954    3 SSCHSQVLLQQLNMQREFGFLCDCTVAIGDVYFKAHRAVLAAFSNYFKMIFIHQSSECIKIQPTDIQPDIFSYLLHVMYT 82   African clawe...
XP_021329052    3 VSGHSLFLLQQLNVQREFGFLCDCTVAIGNVYFKAHRAVLAAFSNYFKMIFIHQSSECIKIQPTDIQPDVFSYLLHIMYT 82   zebrafish
XP_007068062    3 TASHSLVLLQQLNMQREFGFLCDCTVAIGDVYFKAHRAVLAAFSSYFKMIFIHQTSECIKIQPTDIQPDIFSYLLHIMYT 82   green sea turtle
XP_014340771    3 VTSHSLVLLQQLNIQREFGFLCDCTVAIGDVYFKAHRAVLAAFSNYFKMIFIHQPSECIKIQPTDIQPDIFSYLLHIMYT 82   coelacanth

P24278         83 GKgPKQIVDHSRLEEGIRFLHADYLSHIATEMNQVFSPETVQSSNLYG 130  human
NP_001087954   83 GRcPKQSVDHVRLDEGIRFLHANLLTLSANDPIKMFSAETVQSSNLYG 130  African clawed frog
XP_021329052   83 GMgPKQPVDQGRLQEGIKFLHAYQLCRKAGESGPDASSDAIRMSNLYG 130  zebrafish
XP_007068062   83 GKgPKQTVNPSRLEEGIRFLHADYLSHIAIKMNQILSPETMQSSNLYG 130  green sea turtle
XP_014340771   83 GKgPRQSVDHSRLEEGLKFLHANHLSRISTELNQDSAHDNMQASNLYG 130  coelacanth
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