3AL3,3AL2


Conserved Protein Domain Family
BRCT_TopBP1_rpt7
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cd17738: BRCT_TopBP1_rpt7 
seventh BRCT domain of DNA topoisomerase 2-binding protein 1
TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the seventh BRCT domain. The Trp-X-X-X-Cys/Ser signature motif of the BRCT family is missing in this group.
Links
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Statistics
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PSSM-Id: 349370
Aligned: 75 rows
Threshold Bit Score: 70.2893
Created: 4-Apr-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
BACH1
Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:BACH1 interaction site [polypeptide binding site]
Evidence:
  • Structure:3AL3: Homo sapiens Topbp1 BRCT7/8-BACH1 peptide complex, contacts at 4A
    - View structure with Cn3D
  • Comment:the TopBP1-BACH1 interaction s critical for the activation of the DNA replication checkpoint at stalled replication forks
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1              #####      #                                #  #####                       
3AL3_A          9 QYIFQLSSLNpq---eRIDYCHLIEKlGGLVIEKqcf--dptCTHIVVGHp-LRNEKYLASVAAGKWVLHRSYLEACRTA 82   human
KYQ91456      424 TPYFLFSGFSke--gkFYEMLSVIQDlGGILQDRfmp---gvTTHLISKSp-IKSEKFMCSCAAGVWVLAPSYLDEVVEK 497  Dictyostelium...
XP_014676888    7 LRQFQLTGFSke---dRVHIRTLISSlGGACFECesf--kpvTTHLLCARp-TRSEKFLGSCILGIWILRTQYLYDCIAK 80   Priapulus cau...
XP_005842341  790 QPFVLVCGRTa----eRQEQVSIVRRlGGKSAYShhf--dpdTTHVLCTEl-RRTEKFLCACAKGIWILKPEYLQACAQN 862  Guillardia th...
XP_020433890  926 SNYLLLSGFGdkekipLMDSLSKIEK-FGFYHQSdpnitpgkTTHLIVCLp-KRSEKFLCALAAGIWCLKPTFLDAIIAT 1003 Polysphondyli...
XP_641820    1105 KYVFAISGITdd--aeQNQVKDIISRlGGLFEAVia----knVTHVVTKQi-SRSEKIMGGCASGAWILQVSYFTASSNS 1177 Dictyostelium...
XP_003294915  993 TMIFVLSGFAds--deLARYTAMLLRfGGFLESSin----kdVTHVITKQp-SRSEKVMGGSAAGSWILKPSFLVVSNEK 1065 Dictyostelium...
AAC78713     1061 PKFFIVSGPRs----qRNEYQQIIRRlKGKCCRDshqw-syqATHFIAPEi-RRTEKFFAAAASGSWILKTDYVADSKEA 1134 thale cress
XP_002967474  503 DYRFALSGHTe----eKRKHRLVIRSlHGHLCRDdhiw-keqTTHCVMGSplRRTEKLFAALASGRWILKFDYLEACAKA 577  Selaginella m...
OAE32121     1026 KKHFAVGGSTd----eRKNLHYIIKLlGAKVCTNryqw-kddITHVVLPVplRRTEKFLAGAAAGRWILQPEYVEASRKA 1100 Marchantia po...

Feature 1          
3AL3_A         83 G 83   human
KYQ91456      498 K 498  Dictyostelium lacteum
XP_014676888   81 G 81   Priapulus caudatus
XP_005842341  863 G 863  Guillardia theta CCMP2712
XP_020433890 1004 N 1004 Polysphondylium pallidum PN500
XP_641820    1178 G 1178 Dictyostelium discoideum AX4
XP_003294915 1066 G 1066 Dictyostelium purpureum
AAC78713     1135 G 1135 thale cress
XP_002967474  578 R 578  Selaginella moellendorffii
OAE32121     1101 G 1101 Marchantia polymorpha subsp. ruderalis

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