Conserved Protein Domain Family
Delta_COP_N

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cd14830: Delta_COP_N 
delta subunit of the F-COPI complex, N-terminal domain
Delta subunit of the heterotetrameric F-COPI complex, which consists of one beta-, one gamma-, one delta-, and one zeta subunit, where beta- and gamma- subunits are related to the large adaptor protein (AP) complex subunits, and delta- and zeta- subunits are related to the medium and small AP subunits, respectively. F-COPI forms a coatomer together with the B-COPI subcomplex, which assembles with a small GTPase, ADP-ribosylation factor 1 (ARF1), playing an important role in the formation of COPI complex-coated vesicles. COPI complex-coated vesicles function in the early secretory pathway mediating the retrograde transport from the Golgi to the ER, and intra-Golgi transport.
Statistics
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PSSM-Id: 341434
Aligned: 60 rows
Threshold Bit Score: 144.2
Created: 14-Jan-2014
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q5XJY5     4 LAAAVCTkAGKAIVSRQFvemtrtrieglLAAFPKLMNTGk---qHTFVETesVRYVYQPME-KLYMVLITTkn-sNILE 78  house mouse
CBH13575   4 IVAGIVNkQGGIVLSRHFnditrvrveglLSAFPRLMEAStn-kqVTYVDAgaVRYVYQPLD-DLFLVLITTrs-sNIVE 80  Trypanosoma brucei ...
CBZ50029   4 ISACIMS-RQKPLLARQFveiskvrieglMNAFLKLVEHAga--dHTYVESdcARYVYQPLD-NVYLVLITTkh-sNILE 78  Neospora caninum Li...
EAY19238   3 LSVAIINqNGKPLVARQFskvskaqilnqLGVFPKLLTKTs----QSYVESqnIRYVYQNLD-KLYFILITTkd-sNILE 76  Trichomonas vaginal...
AAM46844   4 LSAVIST-KSKILVSRQFrniskcdldslTIPFHNLIERErs--dHTYIETdkVRYVYQPLD-NIYIFLITNin-sNIIE 78  Plasmodium falcipar...
CCF73032   4 ISTGFSS-KTQILLSRQNyeiskqevdttLFNFIKQLNAQcg--dHTYFEFnnHRYIYQPVE-SLYVFVITTkn-sNVIE 78  Babesia microti str...
EAY02606   3 NCVAIITqNGRILIVRRFthssdsnieghLGAFPQLVKNSg----HNYIDTetSRLVYQEVG-DLYVIISVSkd-tNIIE 76  Trichomonas vaginal...
EAN31685   4 LSTGLAS-EMRILVSRQHtqmtreeiescFSNFLRLIENKsg--dHTFVESdkNRFLYQLVD-NFYVFVMTTld-sNIIE 78  Theileria parva str...
EPY35353   4 LAVGVVNrHGRVLVSRQPgditrsrveglLSSFPRLLQSTknrqiATYIDGgeVRYVFMPFMnEFFLVLLTEkedsNIVE 83  Angomonas deanei
EDO06155   4 YGTGIAS-KKRVLLSRQHcelkradlemaLSCFNRMVEKNds--dFTYVETegIRFVYQPVD-DYYVFVMTSid-sNIVR 78  Babesia bovis T2Bo
Q5XJY5    79 DLETLRLFSRVIPEYCra-------------lEENEISEHc----------FDLIFAFDEIVal-----------gyREN 124 house mouse
CBH13575  81 DLDTLHLMGRLITEHVg---------------TVSEVFLQek--------aFKVFFALDEVIvg-----------grREN 126 Trypanosoma brucei ...
CBZ50029  79 DLQTLRVFATIVQDACsgegl------sggvnVEQVVLENa----------FSIIFMVDELIsf-----------glREA 131 Neospora caninum Li...
EAY19238  77 DLELLSMLIDLTRTIIpt-------------iDETTVLSHn----------LDLIFAYDEVIfd-----------gyRQT 122 Trichomonas vaginal...
AAM46844  79 DLEIIKVLSQIIQDICqg------------niNESTILKKc----------FTIIFYIDELIkn-----------gvREI 125 Plasmodium falcipar...
CCF73032  79 DLEVVKMLSQIAQTVTkq------------cvSEKTIMDNi----------FDLIFYMDEIVid-----------gnREA 125 Babesia microti str...
EAY02606  77 ALDAVTLFVDVTRSVVge------------ivEDKIIVNA-----------IDLIFAYDECVfd-----------gfVRN 122 Trichomonas vaginal...
EAN31685  79 DLIVLKTLCEIVQNLVkp------------viNEENILKNi----------FDILFYMDELVsn-----------nqGEN 125 Theileria parva str...
EPY35353  84 DLSTLHLVGRVLSEHMp--------------qTGYDYLDLdfdmlwggalwGDEEGNFDETVehgkgaagegdtsklEES 149 Angomonas deanei
EDO06155  79 DIGIVHTLAEIVQVYGcvnvlmtllqsllqsdIDEGVREQf----------FDIIFYMDELItn-----------kqPED 137 Babesia bovis T2Bo
Q5XJY5   125 VNLAQIRTF 133 house mouse
CBH13575 127 TTTEQIQTY 135 Trypanosoma brucei gambiense DAL972
CBZ50029 132 ISLAQIKTF 140 Neospora caninum Liverpool
EAY19238 123 VSVNDVSEF 131 Trichomonas vaginalis G3
AAM46844 126 VNSNQIKTY 134 Plasmodium falciparum 3D7
CCF73032 126 LTMDQLETY 134 Babesia microti strain RI
EAY02606 123 IIVSDVSRF 131 Trichomonas vaginalis G3
EAN31685 126 MAFDQIKVY 134 Theileria parva strain Muguga
EPY35353 150 IENTGIQIL 158 Angomonas deanei
EDO06155 138 LTIDQIKEY 146 Babesia bovis T2Bo
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