1DVP,3ZYQ


Conserved Protein Domain Family
VHS_Hrs
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cd03569: VHS_Hrs 
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VHS (Vps27/Hrs/STAM) domain of Hepatocyte growth factor-regulated tyrosine kinase substrate, Hrs
Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) plays a role in at least three vesicle trafficking events: exocytosis, endocytosis, and endosome to lysosome trafficking. Hrs is involved in promoting rapid recycling of endocytosed signaling receptors to the plasma membrane. Together with STAM or STAM2, it comprises the ESCRT (Endosomal Sorting Complex Required for Transport)-0 machinery, which functions to bind and sequester cargoes for downstream sorting into intralumenal vesicles. Hrs contains an N-terminal VHS domain, which has a superhelical structure similar to the structure of ARM (Armadillo) repeats, a FYVE (Fab1p, YOTB, Vac1p, and EEA1) zinc finger domain, a Double Ubiquitin-Interacting Motif (DUIM), a P(S/T)XP motif that recruit ESCRT-I, a GAT (GGA and TOM) domain, and a short peptide motif near the C-terminus that recruits clathrin.
Links
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Statistics
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PSSM-Id: 340771
Aligned: 26 rows
Threshold Bit Score: 215.58
Created: 1-Mar-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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FYVE domain
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:FYVE domain interface [polypeptide binding site]
Evidence:
  • Structure:1DVP; Drosophila melanogaster Hrs protein; contacts at 4A between the VHS and FYVE domains
    - View structure with Cn3D
  • Comment:VHS domains are often found in tandem repeats together with FYVE domains
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                        ##  #   #                                        ##          
1DVP_A      4 SSFCKNLENATSHLRlePDWPSILLICDEINQkdvTPKNAFAAIKKKMns-pnPHSSCYSLLVLESIVKNCGAPVHEEVF 82  fruit fly
BAE93270    6 SNFEKVFEKATSNLLlePDLDSMLQLCDMIRGgdvKVREAAALIKMRVieepnPHVQLFAIHVMDTVMKNCGDEIHKCII 85  Ciona intestinalis
ELU04728    7 STFDRLLEKATSHLLlePDWDSILQICDLIRQgdvPPKHAVVSVRKKIgh-enPNVGMFALQCLESMMKNCGSFVHDEVA 85  Capitella teleta
EFX87902    6 SEFDKQLEKATSHLLlePDWQSIIQICDIICQgdcQPKYAITAIKKRFyn-qnPYVALYALQVLESVVKNCGSPIHEEVA 84  common water flea
CBY18102    6 SNFEKLLDKCTANTLlePDWQGMLQLCDMIRGneiKAREAVSYIIKSLnn-qnPYQQFYGFCVLDTVVKNCGPPVHQEVI 84  Oikopleura dioica
CCD82002    7 SKFDKLIEKATSEMLieSDIESIIAVCDNVRSqeiSPKYAVQCLKKRLqc-dnPNVILRSFDVLESLMKNCGTPVHEEVC 85  Schistosoma mansoni
KFD67680    4 KKFERLLDKATDSTLmeADWEMIMSCTDAVRSgevPPKVALSSVRKRVhs-dnPHVAHHALTVLEALVKNCGQRVHKEVA 82  pig whipworm
EUB57490    5 SRFDKLLAKSTSELLmeADWETNLTICDLVRGqevTPKDAINSLKKRLnp-enPHVLMLGLSVLEALMKNCGTPIHDEVL 83  Echinococcus granu...
EGD83121    3 TAFKKALDKATSEELleSNLALYIGVLDHIRGmdvPAKVAMGIMRKRLmh-knPNVALRTLEVIEMAVKNCGAEIQSEVA 81  Salpingoeca rosetta
NP_501375   3 TKFQRVLDQATDSTLvePNWEGIILCTDMIRSgevPAKPSLQAIRKRMqh-enPHVVNHTLLVLDACVKNCGHKVHAEVA 81  Caenorhabditis ele...

Feature 1                                                                        
1DVP_A     83 tKENCEMFSSFLes--------tPHENVRQKMLELVQTWAYAFRssdkYQAIKDTMTILKAKGHTFP 141 fruit fly
BAE93270   86 tESYLEKLKDLVkt--------tKAETIKTKLLDMIQAWGVGFKqskdYKISADLYNIMKAEGYKFP 144 Ciona intestinalis
ELU04728   86 tKEFMEFLRETAhlsepgcgqhgNSNPVKEKVLELIQVWAHAFRsesqYKACQDAYNILKMEGHTFP 152 Capitella teleta
EFX87902   85 sKAFMDELREMVhk--------tTNDKVRAKILELTQTWAFAFRntpkYSIIPDTLNILKAEGYTFP 143 common water flea
CBY18102   85 kHEILEQFRDVVqk-------gsASEDVTKKILEMIQLWGVAGRskseFKVATDVFNVMKAEGYEFP 144 Oikopleura dioica
CCD82002   86 sTDFIQQLVGMVe----------TSPDVRTKLLECLQNWAYVFRdkpgYVAVIDAYENLKNAGYIFP 142 Schistosoma mansoni
KFD67680   83 tKEFMEDLKHLTs---------dCSDKVKDKILELIQCWAHAFRenpdYRIVKDTHNLMKLEGHVFP 140 pig whipworm
EUB57490   84 gTDFVTYLLEYTh----------TNEEVRSRIFGFIQNWEFAFKksenYHYLHEAYDEIKRSGYPLP 140 Echinococcus granulosus
EGD83121   82 tEAFMNDMRKLLk---------sDAVDLRKKVLEVLQVWALAFEkqpaYRVVVDTYNVLRMEGYPFP 139 Salpingoeca rosetta
NP_501375  82 tREFMEDFKNLVte--------nKYDEVKNKSLEMLQCWATAFAnkpeYKMVVDTHNLMKLAGFDFP 140 Caenorhabditis elegans

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