Conserved Protein Domain Family
GCSF

pfam16647: GCSF (this model, PSSM-Id:339790 is obsolete and has been replaced by 406939)

Granulocyte colony-stimulating factor

GCSF is a family of higher eukaryotic granulocyte colony-stimulating factor proteins. Granulocyte colony-stimulating factors are cytokines that are involved in haematopoeisis. They control the production, differentiation and function of white blood cell granulocytes. GCSF binds to the extracellular Ig-like and CRH domain of its receptor GCSFR, thereby triggering the receptor to homodimerize. Homodimerization result in activation of Janus tyrosine kinase-signal transducers and other activators of transcription (JAK-STAT)-type signalling cascades.

Links

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Source:	pfam
Taxonomy:	Boreoeutheria
PubMed:	2 links

Protein:	Representatives
	Specific Protein
	Related Protein
	Related Structure
	Architectures

Statistics

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PSSM-Id:	339790
Aligned:	3 rows
Threshold Bit Score:	258.393
Created:	25-Mar-2019
Updated:	18-Jul-2019

Structure

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PubMed References

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Sequence Alignment

include consensus sequence

Format: Row Display: Color Bits: Type Selection:

P09919  51 VRKIQGDGAALQEKlvsECATYKLCHPEELVLLGHSLGIPWAPLSSCPSQALQLAGCLSQLHSGLFLYQGLLQALEGISP 130 human
P35833  42 VRKIQADGAELQER---LCAAHKLCHPEELMLLRHSLGIPQAPLSSCSSQSLQLTSCLNQLHGGLFLYQGLLQALAGISP 118 cattle
P09920  57 VRKIQASGSVLLEQ---LCATYKLCHPEELVLLGHSLGIPKASLSGCSSQALQQTQCLSQLHSGLCLYQGLLQALSGISP 133 house mouse

P09919 131 ELGPTLDTLQLDVADFATTIWQQMEELGMAPALQPTQGAMPAFASAFQRRAGGVLVASHLQSFLEVSYRVLR 202 human
P35833 119 ELAPTLDTLQLDVTDFATNIWLQMEDLGAAPAVQPTQGAMPTFTSAFQRRAGGVLVASQLHRFLELAYRGLR 190 cattle
P09920 134 ALAPTLDLLQLDVANFATTIWQQMENLGVAPTVQPTQSAMPAFTSAFQRRAGGVLAISYLQGFLETARLALH 205 house mouse

Citing CDD

Jiyao W et al.(2023). "The conserved domain database in 2023.", Nucleic Acids Res. 51(D1):D384-D388.

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