Conserved Protein Domain Family
Gb3_synth
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pfam04572: Gb3_synth (this model, PSSM-Id:335841 is obsolete and has been replaced by 428017)
Alpha 1,4-glycosyltransferase conserved region
The glycosphingolipids (GSL) form part of eukaryotic cell membranes. They consist of a hydrophilic carbohydrate moiety linked to a hydrophobic ceramide tail embedded within the lipid bilayer of the membrane. Lactosylceramide, Gal1,4Glc1Cer (LacCer), is the common synthetic precursor to the majority of GSL found in vertebrates. Alpha 1.4-glycosyltransferases utilize UDP donors and transfer the sugar to a beta-linked acceptor. This region appears to be confined to higher eukaryotes. No function has been yet assigned to this region.
Links
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Statistics
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PSSM-Id: 335841
Aligned: 110 rows
Threshold Bit Score: 80.326
Created: 26-Mar-2017
Updated: 23-May-2017
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q17JV2       242 HEFAESCLNDLALNFDGTQWAANGPFMVTRNLRKFCN-VTD---VSQMN--R-QQCGGq--LTVYPPDVFYRIRYPRHDW 312 yellow fever mo...
EFX81016     224 HPIIRKMITYLASSYHPEEWTYSGPAMFQSIVLKYCR-KRL---PKPTH--PaFLCPG---VKIMPRKYLYPYKFADWKE 294 common water flea
XP_002416293 179 HRFLKTVMKKCAEVYNPTEWTTCGPNLLQSLYQS--------------G--G-SSAQN---LTFLKAETFLAIGWKRWKW 238 black-legged tick
EFX67819     167 HPFLHFLMKYMVLAFEPDNYISLGPDTLRDAMFYFCN-RET---LPANH--W-VNCRHnssIFIQPPESFYAINNSRMET 239 common water flea
EFX82302     191 HKLLKFFMRWMQRSYKPNERSVIGPNGLSRAFQMLCN-HPSkviSDSVY--D-FKCHDgveIRLHNKTAFHPITYFEQNR 266 common water flea
XP_002404889 159 HRFITALMDNCLKGYDPDDYNTCGPGLLQQMY--------------EDG--G-SLATD---MSFLRKETFLAIDIERSGW 218 black-legged tick
EFX60079      98 HPIVRKMMTYLASSYHPKEWSYSGPAMFQSVLLKYCQ--RR---APLPTypV-FLCPD---IRVLPKTYLYPYKFAEWKR 168 common water flea
EFX73043     203 HPLLRFLMKSMILAFRSDNYLSLGPPALTEAILEFCN-RND---LPANK--W-LSCWRnssLFIQPADSFYAIGSGRADA 275 common water flea
EFX70227     228 HPFLQFLMKYMVFAFKPEEYISLGPATLTDSIKYFCD-RTE---LPAEE--W-FMCRNs-sMILQPPRAFYAINNRRQNA 299 common water flea
EFX82299     186 HELLNQYMRLMEREYDPLGRESIGPLAFLKAAREFCGfDVC---DGCNFgqL-WVCRDnwnLTVLYTEAFYPIPFRNRER 261 common water flea

Q17JV2       313 FFYPE-RSEVVMNSIKNDVLVHMWNKATSGIQLKITSTAAYIQLAQQFCPNVVMNV 367 yellow fever mosquito
EFX81016     295 CFRND-VP-RGRDQTSKSYAVHIYNKLSKNEPVLVGSNQIYSRIARIHCPLTYAHA 348 common water flea
XP_002416293 239 FFEQT-RTTAVFQEVRESYGVHLSNHLSKHTTFQIGSGCAYELLAVWNCPRSYKHL 293 black-legged tick
EFX67819     240 FYQPEfDPNDWHLLHRNSFLSHIYGA---GHGRIAPPGSLYAELARKYCPVSYAMA 292 common water flea
EFX82302     267 FYEEN-FDEEELDTFSQSYSVHVYGS---GHGARVPQTSLFAFMANQFCPSTYQfh 318 common water flea
XP_002404889 219 FFDRD-RTASVFKEVRESYGVHIYNSQTKNRTFDIGSGCAYELLAIMNCPRAYEAL 273 black-legged tick
EFX60079     169 MFRfsnv--sgdDAIFQSYAVHTYNKLSKNEPVYVGSNQLYSKIARLHCPITYAHA 222 common water flea
EFX73043     276 FYHpevdpadwiKL-KNSFLSHIYDSGS---RRKIPSSSLYAQLARKYCPIIYRTe 327 common water flea
EFX70227     300 FYHpeadpsdyeDL-RHSYLSHIYDAGN---GRSVPKKSLYGMLAQEFCPTTYQMA 351 common water flea
EFX82299     262 FYEpnfplteldNL-QTSYVVHVYGAGH---GAQVAPSSLYGFLAQRFCPAVYGAg 313 common water flea
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