2AXN,2BIF


Conserved Protein Domain Family
6PF2K
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pfam01591: 6PF2K (this model, PSSM-Id:334602 is obsolete and has been replaced by 396253)
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6-phosphofructo-2-kinase
This enzyme occurs as a bifunctional enzyme with fructose-2,6-bisphosphatase. The bifunctional enzyme catalyzes both the synthesis and degradation of fructose-2,6-bisphosphate, a potent regulator of glycolysis. This enzyme contains a P-loop motif.
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Statistics
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PSSM-Id: 334602
Aligned: 13 rows
Threshold Bit Score: 275.753
Created: 24-Apr-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2AXN_A    26 SCGPKlTNSPTVIVMVGLPARGKTYISKKLTRYLN----WIGVPTKVFNVGEYRREAVKQ-------YSSYNFFRPDNEE 94  human
EEF47903 336 MLGPK-EDRHLAIVLVGLPARGKTFTAVKLTRYLR----WLGHDTKHFNVGKYRRLKHGA-------NQSADFFRGDNPE 403 castor bean
P40433   174 LISKEdSGSKLVIVMVGLPATGKSFITNKLSRFLN----YSLYYCKVFNVGNTRRKFAKEhg---lkDQDSKFFEPKNAD 246 Saccharomyces cerev...
Q06137    74 DSGNLfHAGRILVVLVGLPATSKTLLSVAITRYTR----WLGVRTKSFHFSEYKESAKNI-------PSDYFCVVPTSKE 142 Saccharomyces cerev...
P32604     4 STISNdNDIKVCVIMVGLPARGKSFISQKIIRYLS----WLSIKAKCFNVGNYRRDVSGNv------PMDAEFFNFENTD 73  Saccharomyces cerev...
Q21122    26 VRVPN------VIVMVGLPARGKTYISKKLCRYLK----WTGFTTKVFNVGEYRRSDANAada--ihGANASFFSPNNAD 93  Caenorhabditis elegans
P26285    30 SWASYmTNSPTLIVMIGLPARGKTYVSKKLTRYLN----WIGVPTKVFNLGVYRRQAVKS-------YKSYDFFRHDNEE 98  cattle
Q16875    26 SCGPKlTNSPTVIVMVGLPARGKTYISKKLTRYLN----WIGVPTKVFNVGEYRREAVKQ-------YSSYNFFRPDNEE 94  human
P07953    33 SSIPQfTNSPTMVIMVGLPARGKTYISTKLTRYLN----WIGTPTKVFNLGQYRREAVSY--------RNYEFFRPDNTE 100 Norway rat
Q91348    31 STVPQfTNCPTMVILVGLRRPGKTYISRKLTRYLN----WIGMPTRVFNVGQYRREAVQS-------YKNYEFFRHDNEE 99  chicken
P25114    33 VCMTN---CPTLIVMVGLPARGKTYISKKLTRYLN----WIGVPTREFNVGQYRRDMVKT-------YKSFEFFLPDNEE 98  Norway rat
Q12471    87 PTYTNgKVNKFMIVLIGLPATGKSTISSHLIQCLKnnplTNSLRCKVFNAGKIRRQISCAtiskpllLSNTSSEDLFNPK 166 Saccharomyces cerev...
2BIF_A    33 VCMTN---CPTLIVMVGLPARGKTYISKKLTRYLN----FIGVPTREFNVGQYRRDMVKT-------YKSFEFFLPDNEE 98  Norway rat

2AXN_A    95 AMKVRKQCALAALRDVKSYLAkEGGQIAVFDATNTTRERRHMILHFAKENd--------FKAFFIESVCDDPTVVASNIM 166 human
EEF47903 404 GMEARNEVAALAMDDMIAWMQ-EGGQVGIFDATNSTRERRNMLMKMAEGN---------CKIIFLETICNDERIIERNIR 473 castor bean
P40433   247 STRLRDKWAMDTLDELLDYLLeGSGSVGIFDATNTSRERRKNVLARIRKRsp------hLKVLFLESVCSDHALVQKNIR 320 Saccharomyces cerev...
Q06137   143 GVAFVEKLRMQMLNDILAFFNdLSGQLAIYDALNIRKIDRKNLETTFSEIg--------VKVLFIESIVSDQEIMNRNIA 214 Saccharomyces cerev...
P32604    74 NFKLRELAAQNAIKDIVNFFTkEDGSVAVFDATNSTRKRRKWLKDICEKNn--------IQPMFLESWSNDHELIINNAK 145 Saccharomyces cerev...
Q21122    94 ALKVRAESARRAMEDMADYLNsGTGGVAIFDATNTTKDRRRIIIDFCKKQr--------LRCFFIESVCDDPAIIDCNVT 165 Caenorhabditis elegans
P26285    99 AMKIRKQCALVALKDVKAYLTeESGQIAVFDATNTTRERRDLILNFAEENs--------FKVFFVESVCDDPDVIAANIL 170 cattle
Q16875    95 AMKVRKQCALAALRDVKSYLAkEGGQIAVFDATNTTRERRHMILHFAKENd--------FKAFFIESVCDDPTVVASNIM 166 human
P07953   101 AQLIRKQCALAALKDVHKYLSrEEGHVAVFDATNTTRERRSLILQFAKEHg--------YKVFFIESICNDPEIIAENIK 172 Norway rat
Q91348   100 AMQIRRQCALAALQDVRTYLSsEEGQVAVFDATNTTRERRALIMQFARENg--------YKVLFVESICDDPAIIEENIK 171 chicken
P25114    99 GLKIRKQCALAALNDVRKFLSeEGGHVAVFDATNTTRERRAMIFNFGEQNg--------YKTFFVESICVDPEVIAANIV 170 Norway rat
Q12471   167 NNDKKETYARITLQKLFHEINnDECDVGIFDATNSTIERRRFIFEEVCSFntdelssfnLVPIILQVSCFNRSFIKYNIH 246 Saccharomyces cerev...
2BIF_A    99 GLKIRKQCALAALNDVRKFLSeEGGHVAVFDATNTTRERRAMIFNFGEQNg--------YKTFFVESICVDPEVIAANIV 170 Norway rat

2AXN_A   167 EVKISsPDYKDCNSAE-AMDDFMKRISCYEASYQPLDpdkCDRDLSLIKVID-VGRRFLVNRVQDhiQSRIVYYLMNIHV 244 human
EEF47903 474 LKIQQsPDYAEEPDFEaGYQDFKNRLVNYEKVYEPVE---EGSYIKMIDMVSgHGGQIQVNNISGylPGRIVFFLVNTHL 550 castor bean
P40433   321 LKLFG-PDYKGKDPES-SLKDFKSRLANYLKAYEPIE---DDENLQYIKMID-VGKKVIAYNIQGflASQTVYYLLNFNL 394 Saccharomyces cerev...
Q06137   215 LALES-NDYKGLSTDE-AIDEYMRRLSVNEPYYEMMT---HDEELSYIKYINlGKQIIVKDNIHGylVNKIVFFLMNLRQ 289 Saccharomyces cerev...
P32604   146 DIGSTsPDYENSEPHV-AEADFLERIRQYERFYEPLDp-qKDKDMTFIKLVN-IIEEVVINKIRTylESRIVFYVMNIRP 222 Saccharomyces cerev...
Q21122   166 DVKVNsPDYKGLMTAEqAKEDFMNRIENYKKQYEPLDe-sEDESLSFIKVIN-AGRSFKVHQVRGhvQSRVVYFLMNIHL 243 Caenorhabditis elegans
P26285   171 EVKVSsPDYPERNREN-VMDDFLKRIECYKVTYQPLDpdsHDKDLSFIKVIN-VGQRFLVNKVQDyiQSKIVYYLMNIHV 248 cattle
Q16875   167 EVKISsPDYKDCNSAE-AMDDFMKRISCYEASYQPLDpdkCDRDLSLIKVID-VGRRFLVNRVQDhiQSRIVYYLMNIHV 244 human
P07953   173 QVKLGsPDYIDCDQEK-VLEDFLKRIECYEINYQPLDe-eLDSHLSYIKIFD-VGTRYMVNRVQDhvQSRTAYYLMNIHV 249 Norway rat
Q91348   172 QVKLSsPDYKGCTPEE-AVADFLQRIECYKATYEPLDe-qLDSGLSYIKIFD-VGVRYLANRVQGhvQSRTVYYLMNTHV 248 chicken
P25114   171 QVKLGsPDYVNRDSDE-ATEDFMRRIECYENSYESLDe-eQDRDLSYIKIMD-VGQSYVVNRVADhiQSRIVYYLMNIHV 247 Norway rat
Q12471   247 NKSFN-EDYLDKPYEL-AIKDFAKRLKHYYSQFTPFSldeFNQIHRYISQHEeIDTSLFFFNVIN--AGVVEPHSLNQSH 322 Saccharomyces cerev...
2BIF_A   171 QVKLGsPDYVNRDSDE-ATEDFMRRIECYENSYESLDe-eQDRDLSYIKIMD-VGQSYVVNRVADhiQSRIVYYLMNIHV 247 Norway rat

2AXN_A   245 QP 246 human
EEF47903 551 TP 552 castor bean
P40433   395 AD 396 Saccharomyces cerevisiae S288C
Q06137   290 KK 291 Saccharomyces cerevisiae S288C
P32604   223 KP 224 Saccharomyces cerevisiae S288C
Q21122   244 LP 245 Caenorhabditis elegans
P26285   249 HP 250 cattle
Q16875   245 QP 246 human
P07953   250 TP 251 Norway rat
Q91348   249 TP 250 chicken
P25114   248 TP 249 Norway rat
Q12471   323 YP 324 Saccharomyces cerevisiae S288C
2BIF_A   248 TP 249 Norway rat
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