Conserved Protein Domain Family
P-type_ATPase_APLT_Dnf-like

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cd02073: P-type_ATPase_APLT_Dnf-like 
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. Yeast Dnf1 and Dnf2 mediate the transport of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine from the outer to the inner leaflet of the plasma membrane. This subfamily includes mammalian flippases such as ATP11C which may selectively transports PS and PE from the outer leaflet of the plasma membrane to the inner leaflet. It also includes Arabidopsis phospholipid flippases including ALA1, and Caenorhabditis elegans flippases, including TAT-1, the latter has been shown to facilitate the inward transport of phosphatidylserine. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.
Statistics
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PSSM-Id: 319770
Aligned: 34 rows
Threshold Bit Score: 1121.1
Created: 15-Dec-2004
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1: P-type ATPase signature motif, 7 residue positions
Conserved feature residue pattern:D K [TS] G T [LIVM] [TS]Click to see conserved feature residue pattern help
Evidence:
  • Comment:a characteristic P-type ATPase conserved sequence motif: DK[TS]GT[LIVM][TS], in which D is the reversibly phosphorylated Asp

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                      
Q9NTI2      30 DNQISTAKYSVLTFLPRFLYEQIRRAANAFFLFIALLQqipdvSPTGRYTTLVPLIIILTIAGIKEIVEDFKRHKADNAV 109  human
Q9UT43     233 QNSIVSSRYNKYNFVPLQIIAQFSKTANCYFLLIAIMQmipgwSTTGTYTTIIPLLIFISIAILREGFDNYRRYRQDRVE 312  Schizosaccharomy...
AAQ82704    57 SNFIRTSKYTLISFLPLSLLLEFKKVSNLYFLMNVIFSlipgvSPLSPATSIAPLSFVLIVALIKEGVEDIKRHQADNRA 136  Leishmania donovani
Q9Y2G3      41 DNRIISSKYTVWNFVPKNLFEQFRRVANFYFLIIFLVQlm-idTPTSPVTSGLPLFFVITVTAIKQGYEDWLRHNSDNEV 119  human
AAH53328    42 DNRIVSSKYTVWNFIPKNLFEQFRRIANFYFLIIFLIQai-vdTPTSPVTSGLPLFFVITVTAIKQGYEDWLRHRADHEV 120  African clawed frog
NP_775965   45 DNRIVSSKYTLWNFLPKNLFEQFRRIANFYFLIIFLVQvt-vdTPTSPVTSGLPLFFVITVTAIKQGYEDWLRHRADNEV 123  human
NP_573124   27 LNRVTTTKYTWFTFLPLNFYEQFRRAVYFYFLIITIVSff-vnETISPLVSLLPLLFVMIITALKEGLEDYSRSKSDKLV 105  fruit fly
Q12674     140 DNRITSSRYTFYSFLPRQLYAQFSKLANTYFFIVAVLQmipgwSTTGTYTTIIPLCVFMGISMTREAWDDFRRHRLDKEE 219  Saccharomyces ce...
EAL51558    41 GNKVSTTKYSIISFLPLFLYNQFKHVTNIYFLLVAIISlipqiSATNPITNVLPLVFVLCVSGIKEIIEDIRRWIADRGF 120  Entamoeba histol...
CAD60814    33 DNRIVSSKYTVWNFLPKNLFEQFRRIANFYFLIIFLVQvi-vdTPTSPVTSGLPLFFVITVTAIKQGYEDWLRHKADNEV 111  zebrafish
Feature 1                                                                                      
Q9NTI2     110 N---KKKTIVLRNGm----------------------------------------------------------------- 121  human
Q9UT43     313 N---RIQTQVLRHVdvdppiveehssffrrrrwrrsrsqesasrstirstderepertsedppqlppspsspsspalsvk 389  Schizosaccharomy...
AAQ82704   137 N---SILVQVLRNGk----------------------------------------------------------------- 148  Leishmania donovani
Q9Y2G3     120 N---GAPVYVVRSGg----------------------------------------------------------------- 131  human
AAH53328   121 N---KSTVYIIEGSk----------------------------------------------------------------- 132  African clawed frog
NP_775965  124 N---KSTVYIIENAk----------------------------------------------------------------- 135  human
NP_573124  106 N---TARVTVIRNGk----------------------------------------------------------------- 117  fruit fly
Q12674     220 N---NKPVGVLVKDgnndaqevytlpssvvsstayltksaaaennp--------------------------plnddrns 270  Saccharomyces ce...
EAL51558   121 NnakYTRVNVSDGN------------------------------------------------------------------ 134  Entamoeba histol...
CAD60814   112 N---KYPVTVLEDGr----------------------------------------------------------------- 123  zebrafish
Feature 1                                                                                      
Q9NTI2     122 -----------------------WHTIMWK-----EVAVGDIVKVVNGQYLPADVVLLSSSEpqAMCYVETANLDGETNL 173  human
Q9UT43     390 pnidpqpplynstltttrsipanKPTFFWAscdrkDVRVGDIIRLTSDQTLPADVIALSSPNpnGAIYIETAALDGETSL 469  Schizosaccharomy...
AAQ82704   149 -----------------------LVSVHSK-----DIHPGDVMRIKNGEEVRADVVMLASSVeeGQAFIDTCNLDGETNL 200  Leishmania donovani
Q9Y2G3     132 -----------------------LVKTRSK-----NIRVGDIVRIAKDEIFPADLVLLSSDRldGSCHVTTASLDGETNL 183  human
AAH53328   133 -----------------------CVKKESE-----KIKVGDIVEVRDNETFPCDLVMLSTSCrdGTCTVTTASLDGESNF 184  African clawed frog
NP_775965  136 -----------------------RVRKESE-----KIKVGDVVEVQADETFPCDLILLSSCTtdGTCYVTTASLDGESNC 187  human
NP_573124  118 -----------------------EEIINSQ-----FIVPGDLVVVRNDGDVPCDLVLLQSSSadRKCFVNTANLDGETNL 169  fruit fly
Q12674     271 sqghfldthfnnfellknkynvhIHQKKWE-----KLRVGDFVLLTQDDWVPADLLLLTCDGenSECFVETMALDGETNL 345  Saccharomyces ce...
EAL51558   135 -----------------------LISITSA-----EVRTGYVLELKTNDRIPADCIPLSSSNddGIVFVQTAALDGETNL 186  Entamoeba histol...
CAD60814   124 -----------------------SVKKESE-----KIKVGDVVEVVEDETFPCDLILLQSSRedGTCFVTTASLDGESNH 175  zebrafish
Feature 1                                                                                      
Q9NTI2     174 KIRqgl-shTADMQTREVLMKLsgTIECEGPNRHLYDFTGNLNldgk---------slvALGPDQILLRGTQLRNTQWVF 243  human
Q9UT43     470 KTRlvnstlRSLCKDINDLIRLsgTCTVEDPNGDLYNFNGSMKldsi--------qgeiPLSNNDVLYRGSNLRNTSELF 541  Schizosaccharomy...
AAQ82704   201 KSRkal-eaTWALCEVEAIMNStaVLHTSKPDPGLLSWAGLLEing----------eehALSLNQFLYRGCVLRNTDWVW 269  Leishmania donovani
Q9Y2G3     184 KTHvav-peTALLQTVANLDTLvaVIECQQPEADLYRFMGRMIitqqm------eeivrPLGPESLLLRGARLKNTKEIF 256  human
AAH53328   185 KTYhav-peTAIMGSYEDLNAFsaTIECEQPQPDLYKFHGRIDvntnq------dvkarSLGPENLLLKGATLKNTKKIY 257  African clawed frog
NP_775965  188 KTHyav-rdTIALCTAESIDTLraAIECEQPQPDLYKFVGRINiysnsl-----eavarSLGPENLLLKGATLKNTEKIY 261  human
NP_573124  170 KTIcv---pTNYLLAGDHELQGkdCIVCEPSSADLYTFNGRLElrsgndgagssagdalPLTIDNLLLRGVRVKSTERVV 246  fruit fly
Q12674     346 KSKqphpelNKLTKAASGLANInaQVTVEDPNIDLYNFEGNLElknhrn----dtimkyPLGPDNVIYRGSILRNTQNVV 421  Saccharomyces ce...
EAL51558   187 KEVf-----VPKDLNNIDTLKMvgTMHCNPPNEYFNQYNATISiqdeng-----stkdiPVSAANLLIGGAVIKDTEKCT 256  Entamoeba histol...
CAD60814   176 KTH------YTVPDIERDLQVLtaAIECEQPQPDLYKFVGRMHiykpeq-----eeavrSLGPENLLLKGATLKNTKEIY 244  zebrafish
Feature 1                                                                                      
Q9NTI2     244 GIVVYTGHDTKLMQNSTKAp-lKRSNVEKVTNVQILVLFGILLVMALVSSAGALywnrshgeknwyikk------mdtts 316  human
Q9UT43     542 ALVIFTGEESKIRMNAVRNvsvKAPSMQKVTNRIVIFIFALVVSMAIYCTAAYFvwqkkverklwyl---------tnsk 612  Schizosaccharomy...
AAQ82704   270 GMVAYAGVDTKLFRNLKPKp-pKSSNLDRKLNYFIIAILIFQNIMLFILASMAVwwnskyretpylrffi----sfrknv 344  Leishmania donovani
Q9Y2G3     257 GVAVYTGMETKMALNYKSKs-qKRSAVEKSMNTFLIIYLVILISEAVISTILKYtwqaeekwdepwynqktehqrnsski 335  human
AAH53328   258 GVAVYTGMETKMALNYQGKs-qKRSAVEKSINAFLIVYLCILVSKATICTSLKYlwqsnpandepwyndktrkekeafki 336  African clawed frog
NP_775965  262 GVAVYTGMETKMALNYQGKs-qKRSAVEKSINAFLIVYLFILLTKAAVCTTLKYvwqstpyndepwynqktqkeretlkv 340  human
NP_573124  247 GCAIYTGMHTKLQLNSRYTg-nKSASSEKYINRFMVALIVGMIVVVVVLYLIERhkeakivptmpyqgpp----tnfnsa 321  fruit fly
Q12674     422 GMVIFSGEETKIRMNALKNprtKAPKLQRKINMIIVFMVFVVATISLFSYLGHVlhkkkyidqnkawy-------lfqad 494  Saccharomyces ce...
EAL51558   257 ALVCHCGKHSKLALNQPSLr-tKFAHTDARMNQFVFGIFCFKIVIVIVATIAGSlflvrtgrdswyldm-----edisvg 330  Entamoeba histol...
CAD60814   245 GVAVYTGMETKMALNYQGKs-qKRSAVEKSINAFLLVYLCILISKAVVCTTLKYvwqskegqdepwynektqkeketnmy 323  zebrafish
Feature 1                                                                                    ##
Q9NTI2     317 dnfgynlltFIILYNNLIPISLLVTLEVVKYTQALFINWDTDmyyig-------ndtpaMARTSNLNEELGQVKYLFSDK 389  human
Q9UT43     613 lsfvpilvsFIILYNTMVPISLYVSMEIIRVFQTFLVQSDIDlyype-------ndtrcEVRSSSILEELGQVTHVFSDK 685  Schizosaccharomy...
AAQ82704   345 tlwgyrylsYFILLSYCVPISLFITIEVCKVVQAQWMRVDCLmmeyms-----nrwrhcQPNTSNLNEQLAMVRFIFSDK 419  Leishmania donovani
Q9Y2G3     336 lrfisdflaFLVLYNFIIPISLYVTVEMQKFLGSFFIGWDLDlyhee-------sdqkaQVNTSDLNEELGQVEYVFTDK 408  human
AAH53328   337 lkmftdflsFMVLFNFIIPVSMYVTVEMQKFLGSFFIAWDMEmfdke-------inegaLVNTSDLNEELGQVEYVFTDK 409  African clawed frog
NP_775965  341 lkmftdflsFMVLFNFIIPVSMYVTVEMQKFLGSFFISWDKDfydee-------inegaLVNTSDLNEELGQVDYVFTDK 413  human
NP_573124  322 wqifedflsFLLLFNYMVPISAYMNIEVYRIFGMHFMHNDLHlydee-------tdqpcRVNASNLNEELGQVNILFSDK 394  fruit fly
Q12674     495 agvaptimsFIIMYNTVIPLSLYVTMEIIKVVQSKMMEWDIDmyhae-------tntpcESRTATILEELGQVSYIFSDK 567  Saccharomyces ce...
EAL51558   331 knavqtffrYFGLLSYLIPISCAVSLEVAKFIQTMLMECDTDfniynidedgqlvtekmAAKTSILNDELALVEYVLSDK 410  Entamoeba histol...
CAD60814   324 lkmftdflsFMVLFNFIIPVSMYVTVEMQKFLGSFFIKWDNDffdpe-------ieegaLVNTSDLNEELGQVEYVFTDK 396  zebrafish
Feature 1      #####                                                                           
Q9NTI2     390 TGTLTCNIMNFKKCSIAGVTYGhfpelarepssddfcrmpppcsds---------------------------------- 435  human
Q9UT43     686 TGTLTDNIMLFRNLSVGGFAWQhvgaenpklvstsqksddldgeakppql------------------------------ 735  Schizosaccharomy...
AAQ82704   420 TGTLTENVMKFKLGDALGNPIDadnldeciaqlrk--------------------------------------------- 454  Leishmania donovani
Q9Y2G3     409 TGTLTENEMQFRECSINGMKYQeingrlvpegptpdssegnlsylsslshl----------------------------- 459  human
AAH53328   410 TGTLTENKMEFIECCIDGHKYAntdvmdglpltdgl-------------------------------------------- 445  African clawed frog
NP_775965  414 TGTLTENSMEFIECCIDGHKYKgvtqevdglsqtdgt------------------------------------------- 450  human
NP_573124  395 TGTLTKNLMKFVNCYVPGTNYQlqnthlvsegtde--------------------------------------------- 429  fruit fly
Q12674     568 TGTLTDNKMIFRKFSLCGSSWLhnvdlgnsednfednrdntnslrlppkahngssidvvsigdqnvldrlgfsdapiekg 647  Saccharomyces ce...
EAL51558   411 TGTLTENSMVFKMASVDGEVIEgkkleenfklywnidkekngmevmdkrn------------------------------ 460  Entamoeba histol...
CAD60814   397 TGTLTQNNMEFIECCIDGFQYRhrdahgeldgftvtdg------------------------------------------ 434  zebrafish
Feature 1                                                                                      
Q9NTI2     436 -----------------------------------------------------------cdfddprllkniedrhptapc 456  human
Q9UT43     736 -------------------------------------------------------eniqgttiqllqyvhdnphttfskr 760  Schizosaccharomy...
AAQ82704   455 -----------------------------------------------------------------------eaeskglgp 463  Leishmania donovani
Q9Y2G3     460 -------------------------------------------------------nnlshlttsssfrtspenetelike 484  human
AAH53328   446 ----------------------------------------------------------------------vcfgkasqdr 455  African clawed frog
NP_775965  451 ---------------------------------------------------------------------ltyfdkvdknr 461  human
NP_573124  430 ----------------------------------------------------------------------kfelekldad 439  fruit fly
Q12674     648 hrpsldnfpksrnsieykgnssaiytgrpsmrslfgkdnshlskqasvispsetfsenikssfdliqfiqryptalfsqk 727  Saccharomyces ce...
EAL51558   461 --------------------------------------------------------edinyvsdtkvtmkegvdevkaqa 484  Entamoeba histol...
CAD60814   435 -------------------------------------------------------------------plnklqekagrek 447  zebrafish
Feature 1                                                                                      
Q9NTI2     457 iqeFLTLLAVCHTVVPekdg---------------------dniiYQASSPDEAALVKGAKKLGFVFTartpf------- 508  human
Q9UT43     761 vriFLLNLAICHTCLPsfdee-------------------nqiykYQSISPDELALVHAAQQLGYIVIdrdidsltirlh 821  Schizosaccharomy...
AAQ82704   464 lqeYFLALALCNTVQPfkddtd------------------dlgvvYEGSSPDEVALVETAAAVGYRLIsrttks------ 519  Leishmania donovani
Q9Y2G3     485 hdlFFKAVSLCHTVQIsnvqtdctgdgp------wqsnlapsqleYYASSPDEKALVEAAARIGIVFIgnsee------- 551  human
AAH53328   456 eelFLRALCLCHTVQMkeechtdgp-----------sfsstdncaYISSSPDEIALVTGAKRYGFTYMgtennf------ 518  African clawed frog
NP_775965  462 eelFLRALCLCHTVEIktndavdg-------------atesaeltYISSSPDEIALVKGAKRYGFTFLgnrngy------ 522  human
NP_573124  440 aavLFEALAVCHTVEVlqevgdktlessesvseqshlmsrnivdrYQASSPDEKALLEGCASLGLVYEgqendv------ 513  fruit fly
Q12674     728 akfFFLSLALCHSCLPkkthnes---------------igedsieYQSSSPDELALVTAARDLGYIVLnrnaqilti-kt 791  Saccharomyces ce...
EAL51558   485 ikdYLLALAICNEARPkkeg---------------------dkinYQSQSPDEVALCQQAVDSNVLFFkrtqt------- 536  Entamoeba histol...
CAD60814   448 eelFLRALCLCHTVQVkee------------------------tlSDQIDGIDGVLPKAEEERGFIASspd--------- 494  zebrafish
Feature 1                                                                                      
Q9NTI2     509 -sviieAMGQEQTFGILNVLEFSSDRKRMSVIVRtps--grLRLYCKGADNVIFERLskds------------------- 566  human
Q9UT43     822 ypldphSHPIAKTYRILNIIEFTSKRKCMSVIVRmpn--grICLFCKGADSAIIKRLrlsnlakrkdksvtkaeqarksi 899  Schizosaccharomy...
AAQ82704   520 -itlllHDGTRKVYNILATLEFTPDRKMMSIIVEdsd-tkkITLYNKGADSFIRPQLsr--------------------- 576  Leishmania donovani
Q9Y2G3     552 -tmevkTLGKLERYKLLHILEFDSDRRRMSVIVQaps--geKLLFAKGAESSILPKCigg-------------------- 608  human
AAH53328   519 -msvrnQKDEIERYQLLHVLHFDPVRRRMSVLVKant--gkIFLFCKGADSSMFPRVard-------------------- 575  African clawed frog
NP_775965  523 -mrvenQRKEIEEYELLHTLNFDAVRRRMSVIVKtqe--gdILLFCKGADSAVFPRVqnh-------------------- 579  human
NP_573124  514 lsicryPSAEKVQFKRLHVLEFSSERQRMSVIVRdqs--dtIWLYSKGAESAIFPRCkasp------------------- 572  fruit fly
Q12674     792 fpdgfdGEAKLENYEILNYIDFNSQRKRMSVLVRmpnqpnqVLLICKGADNVIMERLhdrelaakkmadictstkerkda 871  Saccharomyces ce...
EAL51558   537 -mlyvsLFGEILEFKILAIFSFNSDRKRQSVIVQthe--gqIIMYTKGADSIIASRMihed------------------- 594  Entamoeba histol...
CAD60814   495 ---evaLVKGAMEYKLLHVLNFDPVRRRMSVIVQtks--gdTLLFCKGADSSIFPRV----------------------- 546  zebrafish
Feature 1                                                                                      
Q9NTI2         --------------------------------------------------------------------------------      human
Q9UT43     900 eidkaiirnsqstsrpsltasrpslsrrrndyinnvtswlder------------------------------------- 942  Schizosaccharomy...
AAQ82704       --------------------------------------------------------------------------------      Leishmania donovani
Q9Y2G3         --------------------------------------------------------------------------------      human
AAH53328       --------------------------------------------------------------------------------      African clawed frog
NP_775965      --------------------------------------------------------------------------------      human
NP_573124      --------------------------------------------------------------------------------      fruit fly
Q12674     872 eaelvlqqrkslermvdeeamartslrnslssvpraslslqavrkslsmknsrtrdpekqidsidqfletvkksdqeigs 951  Saccharomyces ce...
EAL51558       --------------------------------------------------------------------------------      Entamoeba histol...
CAD60814       --------------------------------------------------------------------------------      zebrafish
Feature 1                                                                                      
Q9NTI2     567 ----------------------------------------------------------------kymeETLCHLEYFAt- 581  human
Q9UT43     943 ---rekmgvvrprastsiletrrrpavgrhslaggerlmedkkylskqeeaegsiyeslnhndaklfeNTFEHVHAFAt- 1018 Schizosaccharomy...
AAQ82704   577 ------------------------------------------------------------------apDVQGHIENVEip 590  Leishmania donovani
Q9Y2G3     609 -----------------------------------------------------------------eieKTRIHVDEFAl- 622  human
AAH53328   576 -----------------------------------------------------------------qveRIKVHVEKNAl- 589  African clawed frog
NP_775965  580 -----------------------------------------------------------------eieLTKVHVERNAm- 593  human
NP_573124  573 -----------------------------------------------------------------lveQTDAQITKYAq- 586  fruit fly
Q12674     952 vvnksrkslhkqqiekygprisidgthfpnnnvpidtrkeglqhdydteilehigsdelilneeyvieRTLQAIDEFSt- 1030 Saccharomyces ce...
EAL51558   595 -----------------------------------------------------------------nfeATNKQLQDFSv- 608  Entamoeba histol...
CAD60814   547 --------------------------------------------------------------------RPEEVDRIRLq- 557  zebrafish
Feature 1                                                                                      
Q9NTI2     582 ------eGLRTLCVAYADLSENEYeewlkvyqeasTILKDRAQRLEECYEIIEKNLLLLGATAIEDRLQAgVPETIATLL 655  human
Q9UT43    1019 ------dGLRTLMYAHRFIDESEYqswklvndaalNSLSNRQQLLDEAADLIEKDLEFAGATAIEDKLQVgVPESINSLF 1092 Schizosaccharomy...
AAQ82704   591 ltemsssGLRTLLVCAKDITRRQFdpwfekfveagKSLHNRSSNIDKVCLEMEQDMRLVGATAIEDKLQDeVPETLSFFL 670  Leishmania donovani
Q9Y2G3     623 ------kGLRTLCIAYRKFTSKEYeeidkrifearTALQQREEKLAAVFQFIEKDLILLGATAVEDRLQDkVRETIEALR 696  human
AAH53328   590 ------dGYRTLCVAFKEISQELYdninkqleeakLALQDREERLAKVFDDIEVDMHLLGATAVEDRLQEqASETIEALH 663  African clawed frog
NP_775965  594 ------dGYRTLCVAFKEIAPDDYerinrqlieakMALQDREEKMEKVFDDIETNMNLIGATAVEDKLQDqAAETIEALH 667  human
NP_573124  587 ------nGLRTMAVGRRMLTDDELfhfeelyrkanTQLSNRNELIASCYETVENELDLLGATALEDALQEhVGETLEALQ 660  fruit fly
Q12674    1031 ------eGLRTLVYAYKWIDIGQYenwnkryhqakTSLTDRKIKVDEAGAEIEDGLNLLGVTAIEDKLQDgVSEAIEKIR 1104 Saccharomyces ce...
EAL51558   609 ------vGLRTLLVTKKEISQEQYnewrkrydeadSSVAGHDENVALIQDEMEVDLKLIGATAIEDKLQDgVPETIEFLI 682  Entamoeba histol...
CAD60814   558 ------dGYRTLCVAYKQLSAEEYaladtglrearLALQDREEKLMAMYNQVETGMSLIGATAVEDRLEE-AAETMEALQ 630  zebrafish
Feature 1                                                                                      
Q9NTI2     656 KAEIKIWVLTGDKQETAINIGYSCRLVSQNMAlillkedsldatraai-----------------------tqhctdlgn 712  human
Q9UT43    1093 RAGIKFWMLTGDKKETAINIGHSCGVIKEYSTvvvmgsldgvegsdetvsggqrlsldrpptndpaslmihqliscmnai 1172 Schizosaccharomy...
AAQ82704   671 SAGVIIWMLTGDKRETAVTIAATSTLCDPRNDfidhidighlnssdpkaierv-------------grdlevveqhialk 737  Leishmania donovani
Q9Y2G3     697 MAGIKVWVLTGDKHETAVSVSLSCGHFHRTMNilelinqksdsecae------------------------qlrqlarri 752  human
AAH53328   664 AAGMKVWVLTGDKLETAKSTCYACRLFQSNTEllelttkdleeyerkedrlqellle-----yhrklvqeapkmkgganr 738  African clawed frog
NP_775965  668 AAGLKVWVLTGDKMETAKSTCYACRLFQTNTEllelttktieeserkedrlhellie-----yrkkllhefpkstrsfkk 742  human
NP_573124  661 AAGLKIWVLTGDKVETAYNIGLACRHIPRGSKqhfiinttepae------------------------------llarld 710  fruit fly
Q12674    1105 RAGIKMWMLTGDKRETAINIGYSCMLIKDYSTvviltttdeniisk--------------------------mnavsqev 1158 Saccharomyces ce...
EAL51558   683 RGGIKVWMITGDKVETAINIGLSCNLLTKETFicklrnapdeienkeefttkkl-----------vemdeeidkeierck 751  Entamoeba histol...
CAD60814   631 GAGMKIWVLTGDKMETAKSTCYACRLFQRGTElleltvrtledgrskredrllellrd---yhrravqdappvktgvvtr 707  zebrafish
Feature 1                                                                                      
Q9NTI2     713 llgkenDVALIIDGHTLKYalsfev-------rrsflDLALSCKAVICCRVSPLQKSEIVDVVKkrv-kaiTLAIGDGAN 784  human
Q9UT43    1173 hsnslaHLVIVIDGSTLADiendpe------lfllfiNTAVEADSVICCRSSPMQKALMVQKVRntlekavTLAIGDGAN 1246 Schizosaccharomy...
AAQ82704   738 gthkerRCTLVIDGPALNIamehy--------fdqflRLSHQVNSAVCCRLTPIQKATVVRMFQkst-gktALAIGDGAN 808  Leishmania donovani
Q9Y2G3     753 tedhviQHGLVVDGTSLSLalreh--------eklfmEVCRNCSAVLCCRMAPLQKAKVIRLIKispekpiTLAVGDGAN 824  human
AAH53328   739 nwtgnqDHGLIIDGATLSLilnsncss--shykniflQICQKCSAVLCCRMAPLQKAQIVKMVKntkgspiTLSVGDGAN 816  African clawed frog
NP_775965  743 awtehqEYGLIIDGSTLSLilnssqdsssnnyksiflQICMKCTAVLCCRMAPLQKAQIVRMVKnlkgspiTLSIGDGAN 822  human
NP_573124  711 migddePEVLIVDGTTITAlleht--------prqfaDLALRCRAVLCCRLSPLQKSEIVTLIKrrk-kyiTAAIGDGAN 781  fruit fly
Q12674    1159 dsgniaHCVVVIDGATMAMfegnpt------ymsvfvELCTKTDSVICCRASPSQKALMVSNIRntdpnlvTLAIGDGAN 1232 Saccharomyces ce...
EAL51558   752 segkayNIGCVFEAGALQVvmaha--------kdlfrQVILKASVVICSRVTPKQKAMIAKTVKeat-kkvVLTIGDGAN 822  Entamoeba histol...
CAD60814   708 swsanqEYGFIIDGATLSLvmnpprdadaslyrglflQICQNCTAVLCCRMAPLQKAQIVKMVKnckgspiTLSIGDGAN 787  zebrafish
Feature 1                                                                                      
Q9NTI2     785 DVGMIQTAHVGVGISGNEGMQATNNSDYAIAQFSYLEKLLLVHGAWSYNRVTKCILYCFYKNVVLYIIELWFAFVNGFSG 864  human
Q9UT43    1247 DIAMIQEAHVGIGIAGREGLQAARSSDFSIGRFKFLIKLLFCHGRWSYVRLSKYILGTFYKEQFFFLMQAIMQPFVGYTG 1326 Schizosaccharomy...
AAQ82704   809 DVSMIREGRVGVGIIGLEGAHAALAADYAIPRFKHLRRLCAVHGRYSLFRNASCILVSFHKNITVSVVQFIFAFYVGFSG 888  Leishmania donovani
Q9Y2G3     825 DVSMIQEAHVGIGIMGKEGRQAARNSDYAIARFKFLSKLLFVHGHFYYIRIATLVQYFFYKNVCFITPQFLYQFYCLFSQ 904  human
AAH53328   817 DVSMILEAHVGIGIKGKEGRQASRSSDYAVPKFKHLRKLLLVHGHLYYVRIAHLVQYFFYKNLCFILPQFLYQFFCGFSQ 896  African clawed frog
NP_775965  823 DVSMILESHVGIGIKGKEGRQAARNSDYSVPKFKHLKKLLLAHGHLYYVRIAHLVQYFFYKNLCFILPQFLYQFFCGFSQ 902  human
NP_573124  782 DVSMIQEAHIGIGITGREGKQAARCADFSIARFEMLRRLFLVHGHYNSQRLAFLVLFYCYKNIIITGCMALYQVYDLYSA 861  fruit fly
Q12674    1233 DIAMIQSADIGVGIAGKEGLQASRVSDYSIGQFRFLLKLLFVHGRYNYIRTSKFMLCTFYKEITFYFTQLIYQRYTMFSG 1312 Saccharomyces ce...
EAL51558   823 DVAMINEGDIGVGLFGKEGTQAARASDYALRKFRHLAKLIMFHGRNSLLRNVTLIKMCFYKNASFFLILFWYSFFNGQSG 902  Entamoeba histol...
CAD60814   788 DVSMILEAHVGIGIKGKEGRQAVRNSDYAIPKLKHLKKLLLAHGHLYYVRIAHLVQYFFYKNLCFILPQFLYQFFCGYSQ 867  zebrafish
Feature 1                                                                                 
Q9NTI2     865 QILFERWCIGLYNVIFTALPPFTLGIFERSCtqESMLRFPQLYKITQNGEgfnTKVFWGHCINALVHSLILFWFP 939  human
Q9UT43    1327 QSLYESWGLTCFNTLFSSLCVIGLGIFEKDLsaSTVIAVPELYQKGINNEafnWRVYFGWCSIAFIQAFLVFYVT 1401 Schizosaccharomyces p...
AAQ82704   889 LTLFDGWMLTFYNVLLTSIPPFFMGIFDKDLpeDALLERPKLYTPLSHGEyfnLATLLRWFVESLTTAVILFYAA 963  Leishmania donovani
Q9Y2G3     905 QTLYDSVYLTLYNICFTSLPILIYSLLEQHVdpHVLQNKPTLYRDISKNRllsIKTFLYWTILGFSHAFIFFFGS 979  human
AAH53328   897 QPLYDAAYLTMYNICFTSMPILAYSLLEQHIniEILSTNPKLYMRISDNAmlqWGPFLYWTLLGAFEGLVFFFGV 971  African clawed frog
NP_775965  903 QPLYDAAYLTMYNICFTSLPILAYSLLEQHIniDTLTSDPRLYMKISGNAmlqLGPFLYWTFLAAFEGTVFFFGT 977  human
NP_573124  862 TNVYNSIYLWLFDIVYISFSFTVLAICDKDYseETLLSHPELYKPLAHNRqasMGVFSLWILNGFVQCFIIFFFT 936  fruit fly
Q12674    1313 SSLYEPWSLSMFNTLFTSLPVLCIGMFEKDLkpMTLLTVPELYSYGRLSQgfnWLIFMEWVILATTNSLIITFLN 1387 Saccharomyces cerevis...
EAL51558   903 MSMYDDYTMTFFNIFITSLPPVFIACLDKDLsyQVIKDNPEVHRGILRGSrmsLASFLDWLGQGIWQSLLLTFVF 977  Entamoeba histolytica...
CAD60814   868 QPLYDAAYLTMYNICFTSMPILAYSLLEQHIaiEILLDNATLYREIAKNAmlrWRPFLYWTVLGIFQGLLFFFGV 942  zebrafish

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