Conserved Protein Domain Family
RING-HC_RSPRY1
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cd16566: RING-HC_RSPRY1 (this model, PSSM-Id:319480 is obsolete and has been replaced by 438228)
RING finger, HC subclass, found in RING finger and SPRY domain-containing protein 1 (RSPRY1) and similar proteins
RSPRY1 is a hypothetical RING and SPRY domain-containing protein of unknown physiological function. Mutations in its corresponding gene RSPRY1 may associate with a distinct skeletal dysplasia syndrome. RSPRY1 contains a B30.2/SPRY domain and a C3HC4-type RING-HC finger.
Links
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Statistics
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PSSM-Id: 319480
Aligned: 16 rows
Threshold Bit Score: 71.2348
Created: 3-May-2013
Updated: 2-Oct-2020
Structure
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Aligned Rows:
Download Cn3D
 
Zn binding siteRING-HC finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Mus musculus RNF146 (4QPL) binds two Zn2+ ions through its RING-HC finger.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          #  #           # #   #  #      #  #    
Q96DX4       525 NCCSLCCDevADTQLKPCGHSDLCMDCALQLEtCPLCRKEI 565 human
NP_001038537 529 NCCTLCCDqmADTELRPCSHSGICMECALQLEtCPLCRQDI 569 zebrafish
ELU18082      58 DSCSLCFDsaAVATLQPCGHRGMCMDCAYQLEiCPLCREAI 98  Capitella sp. I Grassle & Grassle, 1976
XP_006812624 516 GACNLCFDklANTILKPCDHRGLCMECAIQVEiCPLCRTFI 556 Saccoglossus kowalevskii
EEN50252     433 NCCNLCFDnqADTELRPCGHRDLCMTCAIQIEsCPICREPI 473 Florida lancelet
ESO85848     495 DSCTLCFDkqANMELHPCGHNGFCDVCSLQLEtCPICRKPI 535 owl limpet
XP_011667742 371 TACSLCFDkeASVTFRPCGHGGFCPDCAIQLEqCPLCRTII 411 purple sea urchin
XP_013421219 128 DSCTICFDkqDTVMLLPCDHTGFCMDCAMQLEvCPLCRTNI 168 Lingula anatina
EDQ88443     667 DLCTICYAnvPDVIHRPCDHAGFCLTCSLQVEsCPLCRRSI 707 Monosiga brevicollis MX1
XP_013783175 494 DSCTLCFDgkATVRLEPCDHRGFCLHCALQLEvCPMCRSPI 534 Atlantic horseshoe crab

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