3KHQ,3KG5


Conserved Protein Domain Family
IgV_CD79b_beta
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cd16096: IgV_CD79b_beta (this model, PSSM-Id:319345 is obsolete and has been replaced by 409515)
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Immunoglobulin variable domain (IgV)
IgV: Immunoglobulin variable domain (IgV) in CD79B (Cluster of Differentiation 79B). Members of the IgV family are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond.
Links
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Statistics
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PSSM-Id: 319345
Aligned: 5 rows
Threshold Bit Score: 160.117
Created: 2-May-2015
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:homodimer interface [polypeptide binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1     #                           #                                       #           
3KHQ_A     25 RFAAKKRSSMVKFHCYTnh-sGALTWFRKrgs-qqPQELvseegrIVQTQNgsVYTLTIQniqyednGIYFCKQKcdsan 102 house mouse
NP_032365  51 RFAAKKRSSMVKFHCYTnh-sGALTWFRKrgs-qqPQELvseegrIVQTQNgsVYTLTIQniqyednGIYFCKQKcdsan 128 house mouse
NP_598217  51 RFAAKKRSSMVKFHCHTdy-sGVMTWFRQkgn-qrPQELfpedghISQTRNgsVYTLTLQniqyednGIYFCQQKcnste 128 Norway rat
EDM06394  112 RFAAKKRSSMVKFHCHTdy-sGVMTWFRQkgn-qrPQELfpedghISQTRNgsVYTLTLQniqyednGIYFCQQKcnste 189 Norway rat
3KG5_A     26 RFIARKRGFTVKMHCYMnsasGNVSWLWKqemdenPQQLklekgrMEESQNesLATLTIQgirfednGIYFCQQKcnn-t 104 human

Feature 1      #### ## #   
3KHQ_A    103 hNVTDSCGTELLV 115 house mouse
NP_032365 129 hNVTDSCGTELLV 141 house mouse
NP_598217 129 pDVTDGCGTELLV 141 Norway rat
EDM06394  190 pDVTDGCGTELLV 202 Norway rat
3KG5_A    105 sEVYQGCGTELRV 117 human

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