Conserved Protein Domain Family
LIP1
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pfam15904: LIP1 (this model, PSSM-Id:318176 is obsolete and has been replaced by 464931)
LKB1 serine/threonine kinase interacting protein 1
LIP1 is a protein found in eukaryotes. It represents the N-terminus of a leucine-rich-repeat protein that is implicated in Peutz-Jeghers syndrome. LIP1 interacts with the TGF-beta-regulated transcription factor SMAD4 to form a LKB1-LIP1-SMAD4 ternary complex. Mutations in SMAD4 lead to juvenile polyposis, suggesting a mechanistic link between these two diseases.
Links
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Statistics
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PSSM-Id: 318176
Aligned: 9 rows
Threshold Bit Score: 113.659
Created: 30-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q7ZWF6          6 AGQSRVVHRLATLLRNNGDSVLDGSSTLTLQVGCLQHLTQLFERHLLSR-THQHGFLALPSHPADTASLLEVQFLFDMLQ 84   zebrafish
Q5F479          7 AAAEPLVSGLARLLQDTGDLVLDGSSTLTLLTPTLQHLTRVFEQHLGSR-NQHRGFVALPSHPAETTAILQAQFLFDMLQ 85   chicken
XP_011918130    4 AQRDSLVWKLAGLLRESGDVVLSGCSTLSLLTPTLQQLNHVFELHLGPWgPGQTGFVALPSHPADSPVILQLQFLFDVLQ 83   sooty mangabey
XP_014762113    1 -mdpqkITELANLLRQNGDKILSSEFTLTLSGSLLRALNDSFTLIADTEvSHDQGFQVVKPINAKSSVFPDLQLLHDFVQ 79   Drosophila an...
XP_008110022    5 apkeIMLKSLAQLLQDSGDLILDGTSTLTLFTSTLQILTEIFEQHLLPR-NQNHGFIALSSHPAETSAILQAQFLFDVLQ 83   green anole
XP_011604677    6 SSQCPLVHSLAKLLRNDGDLVLDGSSTLTLTASSLQQLTRMFEQYLLPR-SKQHGFLALPSHPADTASLLQLQFLFDVLQ 84   torafugu
XP_011482066    6 SGQSSLVHSLATLLRNNGDVVLDGSSTLTLPAASLQQLTRLFEQHLLPR-SHQHGFLALPSHPADTVSLLELQFLFDILQ 84   Japanese medaka
XP_003272493    4 AQRDSLVCKLAGLLRESGDVVLSGCSTLSLLTPTLQQLNHVFELHLGPWgPGQTGFVALPSPPAHSPvixqlgfvvfsll 83   northern whit...
XP_006636762    6 SGGSTLVHSLASLLRNNGDSVLDGTSTLSLMASSLQHLTRLFEQYLLSR-THQHGFLALPSHPADTASLLQVQFLFDMLQ 84   spotted gar

Q7ZWF6         85 KTVSLKLVNPP 95   zebrafish
Q5F479         86 KTHSLKLIHVP 96   chicken
XP_011918130   84 KTLSLKLVHVp 94   sooty mangabey
XP_014762113   80 KTTLLKLTHFP 90   Drosophila ananassae
XP_008110022   84 KTLSLKLIHVP 94   green anole
XP_011604677   85 KTISLKlinpp 95   torafugu
XP_011482066   85 KTVSLKLINPP 95   Japanese medaka
XP_003272493   84 ptrgwgxglcl 94   northern white-cheeked gibbon
XP_006636762   85 KTISLKarlac 95   spotted gar
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