Conserved Protein Domain Family
CENP_C_N

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pfam15622: CENP_C_N (this model, PSSM-Id:317934 is obsolete and has been replaced by 464778)
Kinetochore assembly subunit CENP-C N-terminal
CENP-C is a vertebrate family that forms a core component of the centromeric chromatin. On depletion of CENP-C proper formation of both centromeres and kinetochores is prevented. The N-terminal of CENP-C is necessary for recruitment of some but not all components of the Mis12 complex of the kinetochore.
Statistics
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PSSM-Id: 317934
Aligned: 13 rows
Threshold Bit Score: 350.71
Created: 5-Apr-2017
Updated: 23-May-2017
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q03188         7 DHLKNgYRRRFCRPSRARDINTEQGQNVLEILQDCFEEKslandfstNSTKSVPNSTR-KIKDTCIQSPSKE--CQKSHP 83   human
NP_001004098   7 DHLKN-YHRRFCRPSRAPNIPTKQGQNMLEILQDCFEEQ--------NSTESLSCSTP-KEKDIYVQSTGKE--RQASHS 74   Norway rat
XP_006931147   7 DHLKNdYRRRFCRPSRAPDINTKQGQNILEILQDCFEEKsltndfstNSTKSVLYSTP-KMEDICIQSSSKEaqCQKSHP 85   domestic cat
XP_012917820   7 DHLKNdYRRRFCRPCRAPDIKTKQGQNILEILQDCFEENslandfstNSTKSLLYSTP-KTGDICIQSPSKEaeCQKSHL 85   domestic ferret
XP_008538567  35 DHLKNdYRRRFCRPSRAPDINMQVGQNILEILQDCFEEEspandfsgNSTKSVVYLTP-KTKDLCVKSPSKEaqCQKSHP 113  Equus przewalskii
XP_003482452   7 DHLKNgYRRRFCRPSRAPDINTEPNQNILEILLDCFEEKslpsdfstNSTKSGLNSTP-KIKDNYIQSPREEiqCQKA-P 84   pig
AAI05483       7 DHLKNdYRRRFCRPSRVPDINTEQGQNILEVLIDCFEEKslandfskNATKSVLYSTP-KTKDICIQSSSKEtqSQKSHP 85   cattle
XP_010594007   7 nhlkndyrrrycrpsRAPDINVEQGKNILEILQDCFEEKslandfstDSTKSVPCSTP-KIKDTCIQSPSKEh--QKSRP 83   African savann...
XP_013001290   7 DHLKNdYRRRFCRPSrAPGINTEQSQNMLEILQNCFEEKslt--dvtNSPESVLYSTL-KIKNSFIQSPSKD--CQISFP 81   domestic guine...
XP_016278716  13 DHLKIsYRTRFCCTSRLPVTDLWQGQNLLENIQDCFEEKsydtgfstNPGSPTLCSTPcKLRNDSYSSPNKE--CQISPS 90   gray short-tai...
XP_005331772   7 DHLKNgYRRRFCRPFRVPDINTGQGKNMLEILQDCFEEKsltndfsiNSTKSVRYSTP-RVKDNSIHSSSKE----KSHS 81   thirteen-lined...
XP_008266024   7 DHLKNdYRRRFCRPSRARNINKEQGQNMLEFLQDCFEERslandfstNSTKSVLCSTP-KVKDSCFQSPGKE--IQKSCP 83   rabbit
XP_015448424  11 DHLKNgYRRRFCRSSRPPDINMGQGQNILVILQDCFEEKslandfstNSTKSVLYSTP-KIKDTCLPSPSREaqCQKSHP 89   black flying fox
Q03188        84 ----KSVPVSSKKKEASLQFVVEPS----EATNRSVQAHEVHQKILATD-VSSKNTPDSKKISS--RNINDHHSEADEeF 152  human
NP_001004098  75 ----ESVPISSRRKEASLQVPAKPS----DPADEPVQANEVHQKILSTD-VVSKSTPDSTKTSS--KGVKGHHGASDE-L 142  Norway rat
XP_006931147  86 ----KSVPVSSRKKEASRQFTVEPR----EVVNRSVQDHEVHQQILATD-VGSKNTPDSRKMSS--EKLKRHHGGVDEeF 154  domestic cat
XP_012917820  86 ----NSVPVSLRKKEASV-----PS----EVDSRSGQDHEVHQQILTAG-IGSKSTPGSRKMSS--KKLKDCHSEADKeL 149  domestic ferret
XP_008538567 114 ----KSIPVSSRKKEASLQFLVEPS----EAANRSVQAHEVHQEILATD-VGAKNTPDSRKMSS--KKVKDHHNEVSEeF 182  Equus przewalskii
XP_003482452  85 ----ESDPVSSKKKQASMQLIVEPG----EAVNTSVQAHEVHHKILAPE-VHSEHTSDLRKMSG--KKLKDHHKEADEeF 153  pig
AAI05483      86 ----KSGPVSSRKKEVPLQLTVEPN----EAVSKSVQDHEVHQKILATD-VHSKNTSDLRKMSS--KKLKDNHNEADEeC 154  cattle
XP_010594007  84 ----KLLPASSRKKEG---FIVEPN----EEISKSVQAPEVHQKTPATD-VGSENTTDLKNVSS--RKQNDHHNEVDEeF 149  African savann...
XP_013001290  82 vssrKSLPFSSRKK-ASLQGVIEPS----EAASRSVQVHEINQKVPEAD-VGSKSTPDLGKKSD--KKTNGLCAETDEeF 153  domestic guine...
XP_016278716  91 ----KTDCVSSVKKKAKTSVLSHQTimlqSQGNNSVLPPEIPQKLSQADlVDLKNTPNLKYASSgaEEFNKIPNEVVEeF 166  gray short-tai...
XP_005331772  82 ----KSVPVSSRKKEAPLQDIIEPN----ETAHKSVQGHEVLQKILATD-IVSRNTPDLKKKSS--KKPSDHPSEAEEeF 150  thirteen-lined...
XP_008266024  84 ----KSVPVSSKKKEDFLPCFEEPS----KTSNRSVQAYEVHQKSLATD-VGSRNTPDSKKISS--RKLDDYESESDEeF 152  rabbit
XP_015448424  90 ----KSVPVSSRKKETSLQLTVEPN----EAVSKSVHTHEVHQKTLATD-VGSKNTPDSRKMSN--KKLKDHHNEADEeF 158  black flying fox
Q03188       153 YLSVGSPSVLLDAKTS----VSQNVIPSSAQKRetYTFENSVNMLPSSTEVSVKTKKRLNFDDKVMLKKI--------EI 220  human
NP_001004098 143 YLPGGSPVVLLGARVS----GSQKAISSGGQKR--VTSRRSADMQSSNTDISFKTRKRLNFEDKVISNTA--------EI 208  Norway rat
XP_006931147 155 YLSVGSPFVLLDAKTC----VSQSAVSSIAQNRktYTSEKSVNTLSSSTEISLKTRKRLNFEDKNISKKV--------EI 222  domestic cat
XP_012917820 150 HLPVGSPFVLLDAKAS----VSQNVISSIAQKK------NSVNTLSSSMEISLKTRKRLNFEDKIALKEV--------EI 211  domestic ferret
XP_008538567 183 YMSVGSASVLSDAKTS----VSKNAVASVVEKRetHSLKNSISMLSSGTESSHKTKKRLNFDD--VLKKV--------AI 248  Equus przewalskii
XP_003482452 154 YLSIGSPS-DLDAKAT----LLQKAVPSVAQKRetYTSENSVNTMSSSTESSRKTKKRLNFGDKDVLKKV--------EI 220  pig
AAI05483     155 YLSIGSPS-DLDIKAS----SLQKGSPSVAQKRetYTSENSVNMLSSSTQISHKTRKRLSFEDKDVSKKV--------EI 221  cattle
XP_010594007 150 YISVGSSSVVLDAKAS----LSQNAIPSIAQKKetYTSENSLNVLSSSTEISCKTKKRLNFED--ISKKV---------- 213  African savann...
XP_013001290 154 YISVGSPSVLLHGKPS----ESQNAISS-AQKRetHT---SGNILSSGTEISLKIRKRLNFEDKDTFRKV--------ER 217  domestic guine...
XP_016278716 167 YLTVGSPGLL--AKETeilpLPKQATPT-AHDRwnHKFGNSVNQQPSLPTSSLKTKKSLNYEDITVWSAV---------- 233  gray short-tai...
XP_005331772 151 YLSVGSPAVLLDAKTS----VSQNTSSSLAQKRetYTFGNSLNMLSSSTEISLKTKKRLNFEDKDIFKKV--------EI 218  thirteen-lined...
XP_008266024 153 YLSVGSPSVVLSAKTS----TSQNAIPSVAQKRetYIFENSENMLSSSTEISLKTKKRLNFEDKDILKNI--------EI 220  rabbit
XP_015448424 159 YLSVGSPSVLLDPKTS----VSQNAISSIAQKRetYTFENSVNMLSSSTEISLKTKKRLNFEDKDISKKVdkdiskkaEI 234  black flying fox
Q03188       221 DNKVSDEEDKTSEG-QERKPSGSSQNRiRDSEYEIQRQAKKSFSTLFLETVKRKSESSPIVRHAATAPPHSCP 292  human
NP_001004098 209 ESSASQVEDSISEE-QEGTSSETSQKR-DDLSSEIQPQSKKSFSELYLETVNRKSKCSSVVRHTAAVPSPPYP 279  Norway rat
XP_006931147 223 PNELSETEDKVSEEpQERKSSRTSQKRvQDSEYEVQPQTKKSFSALFLETVKRKSESSPVVRHIATAPPHSSP 295  domestic cat
XP_012917820 212 ANKIPEIEDKGSEEpQERKLSRASQKRvPDLEDEIHPQTKKSFSTLFLETVKRKSESSPVVRHIATAPLHSSP 284  domestic ferret
XP_008538567 249 ESKVSEIEDKVSEGpQEKKPSGASQKRiQDSEYEIQPEAKKSFSTLFLETVKGKSESSPIVRHIATTPPHSSv 321  Equus przewalskii
XP_003482452 221 VNNTSEIGDKVSEGpQEKKQSGTSEKRiQGSEYEDQPQTRKSFSTLFLETVKRKNESSSVVRHT-TAPPHLSP 292  pig
AAI05483     222 MNEVSEIEDKVSEGlQERKQSGTSQKRiQDSEYENQPQARKSFSTLFLETVKRKSESSSVVRHIATVPPHLSs 294  cattle
XP_010594007 214 -----EIEDKVLEGpQGKKASGTPQKRtQDSEYEIQPKAKKSFSILFLETVKRKTESSPVIRHVATDPPHSSP 281  African savanna elephant
XP_013001290 218 ETDKSKVENKIL-GqEEKKVSETSSKRlQDTEYEIKSQAKKSFSTLFLETIKRNNESSSVVRHTSTAPSHSSP 289  domestic guinea pig
XP_016278716 234 --KTAEKDIKLSERrQKRIQSE-SEKGsQDTKQKIQQRAKTNFSTLLLEAAKGNCRNSSVHRHV-------SP 296  gray short-tailed opo...
XP_005331772 219 ENKVSEVENKIPEGqQERKPSETFQKSvQDLEHEIQPQTKKSFSTLFLETVRRKSEFSPIVKHIVTAPPHSSs 291  thirteen-lined ground...
XP_008266024 221 ENEVSEVEDKISER-QERKQSETSQKRiQSLELEIQPQATKRFSTLFLETVTRKSESSPIVRHTATASPHLSP 292  rabbit
XP_015448424 235 ENKVSDIQDEVSGRpQERKLAEASQKRiQGSEYEIQSQAKKSFSTLFLETLKRKSESSPVVRHIATAPLHSSP 307  black flying fox
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