Conserved Protein Domain Family
MAJIN
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pfam15077: MAJIN (this model, PSSM-Id:317491 is obsolete and has been replaced by 464488)
Membrane-anchored junction protein
Membrane-anchored junction protein (MAJIN) is a meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. It is a component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes.
Links
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Statistics
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PSSM-Id: 317491
Aligned: 7 rows
Threshold Bit Score: 406.954
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q9D992         1 MSLKPFTYPFPETRFLHAGPNVYKFKIRYGNSIRGEEIEDKEVIVQELEDSIRAVLANMDSLQPFVTEHFIVFPYKSKWE 80  house mouse
XP_015316798   1 MSLKPFTYPFPETRFLHAGPNVYKFKIRYGNSIRGEEVENKEVIVQELEDSIRAVLGNLDNLQPFATEHFIVFPYKSKWE 80  cattle
XP_013006196   1 MSLKPFTYPFPETRFLHAGPSVYKFKIRYGHSVRAEEITDKEVIIQELEDSIRAVLGNLDNLQPFITEHFIVFPYKSKWE 80  domestic guinea...
EHB04907       1 MSLKPFTYPFPETRFLHAGPSVYKFKIRYGHSIRTVATLLKSFQIYLFQDSIRAVLENLDNLQPFVTEHFIVFPYKSKWE 80  naked mole-rat
XP_011719031   1 MSLKPFTYPFPETRFLHAGPNVYKFKIRYGNSIRGEEIENKEVIIQELEDSIRVVLGNLDNLQPFATEHFIVFPYKSKWE 80  pig-tailed macaque
XP_010597473   1 MSLKPFTYPFPETRFLHAGPNVYKFKIRYGNSIRGEEVENKEVIVRELEDSIRVVLGNLDNLQPFTTEHFIIFPYKSKWE 80  African savanna...
XP_013976763  12 MSLKPFTYPFPETRFLHAGPNVYKFKIRYGNNIRGEEIEDKEVIVQELEDSIRVVLGNLDSLQPFATEHFIIFPYKSKWE 91  dog

Q9D992        81 RVSHLKFKHGESILTPYPFVFTLYIEMKWFAEDLPSGKPADDIPLELVLAETEAEEATMRkwKRKLMEEPSSPSRQGPHR 160 house mouse
XP_015316798  81 RVSHLKFKHGEAVLVPYPFVFTLYVEMKCFHENLSPGKSMNSSPLGLVLAERKTAEAVLK--KRKRGEVPSSPARPGLDR 158 cattle
XP_013006196  81 RVSHLKFKHEEVVLIPYPFVFTLYVEMKWFHENLPPGKPINDSPLGSAVAEKKAAGDAGK--KRKLVEEHGSPRGTALPR 158 domestic guinea...
EHB04907      81 RVSHLKFKHEDVVLIPYPFVFTLYVEMKWFHENLSPGRPINDSPLGLVVVEKKAAGASKKq-KRKLVEQHSSPGGARQPR 159 naked mole-rat
XP_011719031  81 RVSHLKFKHGEIILIPYPFVFTLYVEMKWFHENLSPGKPISDSPLGLVPAEKKAVGAVMR--KRKHMDEPSSPSRPGLDR 158 pig-tailed macaque
XP_010597473  81 RVSHLKFKHGEVVLVPYPFVFTLYVEMKWFHENLSPGKLINDSPLGLVSAEKKSAEAMMR--KRRHTEVPSSPRKSGpdR 158 African savanna...
XP_013976763  92 SISHLKFKHGEIVLVPYPFVFTLYVEMKWFHESLSAGKPIKDSPLGLVLTERKAAGAMMR--KRKQVEVLSSPSRPGLDR 169 dog

Q9D992       161 A-KMETSSEASSNKKPLKESKRST---DEEAQQEYQDTPASNAIAVKEQDAALGHGLQGLVVPPLQHSSPPPPKEP---G 233 house mouse
XP_015316798 159 A-EMGTSSQGLSKKKPPMETRRNR---ERKTQQECQKTPAFDVTDVQDQDSKWEDSLVGKTIPPSQQNNPPPAEGPtelG 234 cattle
XP_013006196 159 AkMGSPSRRARSKKPPME--TTRN---RKKTQQETWKTVTSDTTDVQTQDSKRGHNLPGAMVPALQQSSSPPPQEP---G 230 domestic guinea...
EHB04907     160 D-KMRSSSQRPSTKKPPMGTRRNR---ERKPQQERQKTVASDTTDVQEQHSKWGHNLPGAIVPPLQQNNSPPPKEL---G 232 naked mole-rat
XP_011719031 159 T----------GKEKPNKDCRRLW---PLISLVSRNKILSG-GTACQ-----------GQLSHPCSTTH-LHLRSE---Q 209 pig-tailed macaque
XP_010597473 159 A-KVETSSEAPSKKKPPMETRRDRerkTEQEQQE---TPAFDATDVQEQGPKWGDSLAGQMAPSLQWNNPPPPKGPkelG 234 African savanna...
XP_013976763 170 A-KIGISSQSPSKKKPLMETRRNR---EGKTHQEWQETPAFNITDVQEQDSKSEDSPAGQIIPPLQQNNPLPPKGPtelA 245 dog

Q9D992       234 ARGFLGF 240 house mouse
XP_015316798 235 TSGFFGF 241 cattle
XP_013006196 231 TRSFFGF 237 domestic guinea pig
EHB04907     233 IRSFFGF 239 naked mole-rat
XP_011719031 210 PAASLGF 216 pig-tailed macaque
XP_010597473 235 TTGFFGF 241 African savanna elephant
XP_013976763 246 TGGFFGF 252 dog
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