Conserved Protein Domain Family
CAML
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pfam14963: CAML (this model, PSSM-Id:317387 is obsolete and has been replaced by 464408)
Calcium signal-modulating cyclophilin ligand
Calcium signal-modulating cyclophilin ligand was originally identified in a screen for cyclophilin B-interacting proteins. It is likely to be involved in calcium signalling. It has also been shown to interact with many other signalling molecules including proto-oncogene tyrosine-protein kinase LCK, tumor necrosis factor receptor superfamily member 13B and EGFR.
Links
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Statistics
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PSSM-Id: 317387
Aligned: 14 rows
Threshold Bit Score: 414.582
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q90700        19 SASQRRAELRRRKLLMNSEERINRIMGFHRPAAG--KDD---ESHv---eSKlQHEQDK---SNSLPLPSVSKRI--VLG 85  chicken
Q6DGG9        21 SASQRRAELRRRKLLMNSEQRINRIMGFHRPGSG--AEE---ENQt---kSK-PLDSDI---LNPLGVPSVSKRV--VLG 86  Norway rat
NP_990293     19 SASQRRAELRRRKLLMNSEERINRIMGFHRPAAG--KDD---ESHv---eSKlQHEQDK---SNSLPLPSVSKRI--VLG 85  chicken
XP_002744210  23 sasqrraeLRRRKLLMNSEQRINRIMGFHRPGSGa--EE---ESQt---kSK-QQDSDK---LNSLSIPSVSKRV--VLG 88  white-tufted-ea...
XP_003756505  25 SASQRRAELRRRKLLLNSEQRINRIMGFHRSGSA--TEE---EINt---eSK-QRDIDK---LNSLPVPSVSKRV--VLG 90  Tasmanian devil
XP_005807258  12 SAAQQRAEKRRRKLLLNSEDRMNRIVGFAKTEPDhsaag------lrsvePRfHLDLDRsepws---------------- 69  southern platyfish
XP_004076103  18 SAAQRRAEMRRRKLLLNSEDRLNRIVGFAKNGSDnnGAS---RRPaep---rfhLDLDR---TEPWSPSSSSQRPspFLP 88  Japanese medaka
CAG08807       2 SAAQKRAEIRRRKLLMNSEERMNRIVGCTTNSSEnh-------------ePRfHLDLDR---TEPVSSSSSPKRS----- 60  spotted green p...
XP_011609657  13 SAAQRRAEIRRRKLLMNSEERMNRIVGYTKNDSEssagas-----rrstePHfHLDLAR---TEPVSSSSSPKPS----- 79  torafugu
XP_003451453  15 SAAQKRAEIRRKRLLMNSEDRMNRIVGITKNEPEnnGASrrpAEPrfhlpLEpWSTASSsprPSPGI------------- 81  Nile tilapia

Q90700        86 DSvsnvSGAADHA-GSVGDLKG----DK--DLFskTPQLVSEGTGE-------------LRHRNRGELpSE-AAARPPRH 144 chicken
Q6DGG9        87 DSv--dGGVTDYQpSGGADIRGaqlgDKl-DSFikAPECSSKDGVE-------------LRQRNRGDL-TAdSAPRGSHH 149 Norway rat
NP_990293     86 DSvsnvSGAADHA-GSVGDLKG----DKdlFSK--TPQLVSEGTGE-------------LRHRNRGEL-PSeAAARPPRH 144 chicken
XP_002744210  89 DSv--sTGTTDQQ-GGMAEVKGtqlgDKl-DSFikPPECSNDVNLE-------------LRQRNRGDLtAD-TVHRGSRH 150 white-tufted-ea...
XP_003756505  91 DSt--sTGTVDHQ-SGTTEIKGtqlvDKk-DSLinPPDSSNDGNLE-------------LRHRKR-DLtTE-TVQRSSQH 151 Tasmanian devil
XP_005807258  70 ---spsprPGARShTATPERRGsplpDFg-QPR---RASLEGDVGG-------------LRHRAK----ASdEAGGSPRR 125 southern platyfish
XP_004076103  89 ES----SALSSLShTATPERRGsplpDCs-EPP----PAVEDDVGA-------------LRQRLKGERaPSdNISGSPRR 146 Japanese medaka
CAG08807      61 ------SAHGSRShSATPERRAsplpGFs-ESL---GGSLEDDLAG-------------IRKRTRGDR-VSdDLNSSARP 116 spotted green p...
XP_011609657  80 ------SGHGSRShSATPERRAsplpGF-----------------SetlcgsleddlagIRKRTRGDR-VSdDLNSSPRP 135 torafugu
XP_003451453  82 ------G---SHShSSTPERRGsplpELs-SEP--PGGSSEDDIGG-------------VRRRPRGER-PSdDVSGSPRP 135 Nile tilapia

Q90700       145 GL--EQYLSRFDEALKLRNQLMNEKPSQENGNAVEEFDSFRIFRLVGCALLAIAVRAFVCKYLSIFAPFLTLQLAYMGLS 222 chicken
Q6DGG9       150 GL--EQYLSRFEEAMKLRKQLISEKPSQEDGRTTEEFDSFRIFRLVGCALLALVVRAFVCKYLSIFAPFLTLQLAYMGLY 227 Norway rat
NP_990293    145 GL--EQYLSRFDEALKLRNQLMNEKPSQENGNAVEEFDSFRIFRLVGCALLAIAVRAFVCKYLSIFAPFLTLQLAYMGLS 222 chicken
XP_002744210 151 GL--EQYLSRFEEAMKLRKQLISEKPNQEDGSTTEEFDSFrIFRLVGCALLALGVRAFVCKYLSIFaPFLTLQLAYMGLY 228 white-tufted-ea...
XP_003756505 152 GL--DQYLSRFDEAMKLRKQLISEKPSQENGSTGEEFDTFRIFRLVGCALLALGVRAFVCRYLSIFAPFLTLQLAFMGLS 229 Tasmanian devil
XP_005807258 126 GL--HQYLSRFDDAMKLRSQLANEKPAQDGDSDVEEFDPFRVFRLVGSVLLAVFVRVFVCKYLSIFAPFLTLELAYMGLS 203 southern platyfish
XP_004076103 147 GL--QNYLSRFDDAMKLRGQLASEKPTQDGGVETEEFDPFRVFRLVGSILLAVFVRMFVCKYLSIFAPFLTLELAYMGLS 224 Japanese medaka
CAG08807     117 GL--QKYLSRFDDAMKLRGQLASEKPVQDRGSDAEEFDPFVVFRLVGSVLLAVFVRLFVCKYLSIFAPFLTLELAYMGLS 194 spotted green p...
XP_011609657 136 GL--QKYLSRFDDAMKLRGQLANEKPAQDGGSDLDEFDPFIVFRLVGSVLLAVFVRLFVCKYLSIFAPFLTLELAYMGLS 213 torafugu
XP_003451453 136 GFlsASYLSRFDDAMKLRGQLANEKPAEDGGSDSEEFDPFRVFRLIGSVLLAVFVRVFVCKYLSIFAPFLTLELAYMGLS 215 Nile tilapia

Q90700       223 KYFPKSEKKVKTTVLTAALLLSGIPAEVISRSMDTYSKMGDVFTDLCVYFFTFIFCHELTLFFG 286 chicken
Q6DGG9       228 KYFPKGEKKVKTTVLTAALLLSGIPAEVINRSMDTYSKMGEVFTDLCVYFFTFIFCHEVLEYWG 291 Norway rat
NP_990293    223 KYFPKSEKKVKTTVLTAALLLSGIPAEVISRSMDTYSKMGDVFTDLCVYFFTFIFCHELTLFFG 286 chicken
XP_002744210 229 KYFPKSEKKIKTTVLTAALLLSGIPAEVINRSMDTYSKMGEVFTDLCVYFFTfIFCHELLDYWG 292 white-tufted-ear marmoset
XP_003756505 230 KYFPKSEKKVKTTVLTAALLLSGIPAEVISRSMDTYSKMGDVFTDLCVYFFTFIFCHELLVFWG 293 Tasmanian devil
XP_005807258 204 KYFPKVEKKSKTTVLTAALLLSGIPAEVISRSMDTYRRMGDVFSDLCVYFFTFIISHEILTLFG 267 southern platyfish
XP_004076103 225 KYFPKVEKKTKTTVLTAALLLSGIPAEVINRSMDTYRRMGDVFSDLCLYFFTFVLCHELLLLCG 288 Japanese medaka
CAG08807     195 KYFPKVEKKAQTTVLTAALVLSGIPAEVINRSMDTYRRMGDVFADLCVYFFTFILSHEILLLFG 258 spotted green pufferfish
XP_011609657 214 KYFPKVEKKAQTTVLTAALLLSGIPAEVINRSMDTYRRMGDVFADLCVYFFTFILSHEILLLFG 277 torafugu
XP_003451453 216 KYFPKVEKKTQTTVLTAALLLSGIPAEVINRSMDTYRRMGDVFADLCVYFFTFILSHEILLLIG 279 Nile tilapia
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