Conserved Protein Domain Family
TORC_C

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pfam12886: TORC_C (this model, PSSM-Id:315546 is obsolete and has been replaced by 463740)
Transducer of regulated CREB activity, C terminus
This family includes the C terminal region of TORC proteins. TORC (Transducer of regulated CREB activity) is a protein family of coactivators that enhances the activity of CRE-depended transcription via a phosphorylation-independent interaction with the bZIP DNA binding/dimerisation domain of CREB (cAMP Response Element-Binding). The C terminus region is negatively charged, resembling the transcription activation domains. When this domain, from all three human TORC proteins, was expressed as fusion proteins with the DNA-binding domain of GAL4 (GAL4-BD), and tested for induction of a minimal promoter linked to GAL4-binding sites (UAS-GAL4), UAS-GAL4 was potently induced by GAL4-BD fusions containing the C-terminal portion of all three human TORCs.
Statistics
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PSSM-Id: 315546
Aligned: 17 rows
Threshold Bit Score: 82.4268
Created: 28-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q0IHT3       563 PNIILT----DDSSN--SLSKDISNAVAGVSElGFDADNT---FQLDd--ELKLGPLSLDGLSMLSD-PDMvLPDPSIED 630 tropical clawed...
XP_783622    617 PDIIFTg--aGESPPrqELAREISNAMASMDS-NFEHDLL---FSTD---SLNVDPLDLEHLQMLSD-NDI-VADQATED 685 purple sea urchin
XP_001623716 718 PDLIVTd--aNDESQklDFARDLSSAMQGMGGdMYNNDDL----------RVELDPLDMESLQMLSGhGDAeVADQATED 785 starlet sea ane...
EFX87577     504 PDIVLQdfscTPEELarHNSHDLSSAMGS----SFEGVDF---YPTDdalRDGLDPIDFDGLQILTN-STL-VTDPSTED 574 common water flea
XP_008994678  67 PNIILTv--tGESPP--SLSKELTSSLAGVGDvSFDSDSQ---FPLDe---LKIDPLTLDGLHMLND-PDMvLADPATED 135 white-tufted-ea...
XP_011614882 478 PNIILTv--sGESPP--SLLKDLTGSLTT--DiSFDIDSQ---FPLDd---LKLDPLTLDGLHLLND-PDIvLADAATED 544 torafugu
AAH28886      79 PNIILT----GDSSP--GFSKEIAAALAGVPGfEVSAAGLelgLGLEd--ELRMEPLGLEGLNMLSD-PCAlLPDPAVEE 149 human
XP_006008651 661 PNIILT----GDSPP--GFSKEITNALAGIPGfEMDAP-----FGLDe--DLKIEPFTLEGLNMLSD-PYIvLPDPSVED 726 coelacanth
XP_007233417 765 PNIILT----GDSPP--GLSKEITSALSGVPGfEVDP------FSSDd--PLRMDPLALDGLGMLTD-GDLmLADPAVED 829 Mexican tetra
XP_002601596 398 PDIILTg--aGESPPrqDFAKDLGSAMASMAS-GFDSDTL---FAADdplKVGIDPLDLESLQMLTEpSDM-VADPATED 470 Florida lancelet
Q0IHT3       631 SFRSD 635 tropical clawed frog
XP_783622    686 SFRQD 690 purple sea urchin
XP_001623716 786 QFRMD 790 starlet sea anemone
EFX87577     575 HFRLD 579 common water flea
XP_008994678 136 TFRMD 140 white-tufted-ear marmoset
XP_011614882 545 AFRLD 549 torafugu
AAH28886     150 SFRSD 154 human
XP_006008651 727 SFRTD 731 coelacanth
XP_007233417 830 SFRSD 834 Mexican tetra
XP_002601596 471 SFRMD 475 Florida lancelet
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