Conserved Protein Domain Family
3-PAP
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pfam12578: 3-PAP (this model, PSSM-Id:315286 is obsolete and has been replaced by 463634)
Myotubularin-associated protein
This domain family is found in eukaryotes, and is typically between 115 and 138 amino acids in length. Myotubularin is a dual-specific phosphatase that dephosphorylates phosphatidylinositol 3-phosphate and phosphatidylinositol (3,5)-bisphosphate. 3-PAP is a catalytically inactive member of the myotubularin gene family, which coprecipitates lipid phosphatidylinositol 3-phosphate-3-phosphatase activity from lysates of human platelets.
Links
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Statistics
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PSSM-Id: 315286
Aligned: 24 rows
Threshold Bit Score: 90.1342
Created: 27-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q3V1L6       553 QQQSLMVPGPPSsmwlfsrGTLTPLNQLCPWQDSSSLLAVSShwlprPARSSESLAdqEWGLPSHWGACPLPP-GLLLPG 631 house mouse
A2BGG1       551 LSLPSSAFKTPT-------KKGFFKDETDSLKKMLRVKRISR-----WMGSPDSPVvaSREFYESWQQRPLDYhGLLLPS 618 zebrafish
XP_006628855 570 KYHSSTMRGMPs------lRNGLMSEQDSIPRRNSLVLRLKPdf--sQLREPQDSP--SEQFFRDWLSRPPDLqGLLLPQ 639 spotted gar
XP_015461610 448 LSLPSSAFKTPP-------KKGFFKDETESLKKMLRVKRISR-----WMASPDSPAanTREFYEAWQRRPLDHhGLLLPW 515 Mexican tetra
XP_002412392 509 rayrNVWDWSGPesrlsaqDLELFQNPLYLLRRSRELLNAGRpv--pPPLPPSGSG--DRR------CAPSEDeDLLSMD 578 black-legged tick
XP_005467113 563 KAYSSTLRGPPTn-----lRNGVKGGEETLTRRSSLANELKSel----tPVKDESP--SERFFKDWFSRPADLqGLLIPL 631 Nile tilapia
XP_007241217 330 KNYSSTLRGVPTa-----lRNGVSNDHDTLPRRNSLMPRLRPdl--aQLREQQESP--AERFLQDWLSRPADPqGLLLPQ 400 Mexican tetra
XP_319467    527 AALTVPSASSSSsspqnpiQNSLFNARRAEDSNGQTIVNVVGk--------------lQLYFFPLNLVFNQNNeQFLEPQ 592 Anopheles gambi...
KFV43849     226 LSLPLTQTKPST-------KRGFFREETDHLIKNILGKRIGK-----FINSSDEPPnsFREFYDSWHSKPIDYhGLLLPR 293 Gavia stellata
CAH10604     210 LSLPLTQSKSSP-------KRGFFREETDHLIKNLLGKRISK-----LINSSDELQdnFREFYDSWHSKSTDYhGLLLPH 277 human

Q3V1L6       632 YLGPQIRFWKRCYLRGRPEVQMGSSAL------------TVSALQDELSHLQELLRQWTPRISP 683 house mouse
A2BGG1       619 LDGPSVRIWMQRYLRWIPEVHIMGGGSvai-------mtKLMELLSQVEDLKRVLEQRDPSLAT 675 zebrafish
XP_006628855 640 LLPSHIKLWKLYFLRWIPEAQINGGGFita-------fhKVSLLADEIEKLQNQLRQYKGNPCP 696 spotted gar
XP_015461610 516 LDGPAVRLWMQRYLRWIPEVQILGGGPvav-------tnKMAELLVQVQELRKKLDLKGCWQPE 572 Mexican tetra
XP_002412392 579 ATVKALSVWTQCYFRWVPKAEVVNGDPgtlflhnvrvarDIQFLAAQV----RLLREHRRDGVE 638 black-legged tick
XP_005467113 632 LMPSHMAFWKLFFLRWVPEACISKGGPvtt-------yhKLSQLVDEIEILQSQLRQYKGTSPG 688 Nile tilapia
XP_007241217 401 LLPSHLPLWKLYFLRWVPEARIPHGGPvta-------fhKLSVLADEIEMLQNQLRQYNGGAtp 457 Mexican tetra
XP_319467    593 CCLRDIELWQQCYFRWMPHLEIKYGGMaqcdlfnrillnNIFKLRQNLD---------QSVLSE 647 Anopheles gambiae str. PEST
KFV43849     294 VDGPEIKVWAQRYLRWIPEAQLHGGGTiat-------aaKILDLMEEVQSLQVKMDEEHSQAI- 349 Gavia stellata
CAH10604     278 IEGPEIKVWAQRYLRWIPEAQILGGGQvat-------lsKLLEMMEEVQSLQEKIDERHHSQQa 334 human
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