Conserved Protein Domain Family
HoxA13_N
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pfam12284: HoxA13_N (this model, PSSM-Id:315049 is obsolete and has been replaced by 463521)
Hox protein A13 N terminal
This family of proteins is found in eukaryotes. Proteins in this family are typically between 149 and 306 amino acids in length. The family is found in association with pfam00046. This family is the N terminal of the Hox gene protein involved in formation of the digital arch of the hands and feet as well as in correct genital formation. Mutation of the protein is associated with hand-foot-genital syndrome.
Links
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Statistics
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PSSM-Id: 315049
Aligned: 23 rows
Threshold Bit Score: 81.4538
Created: 27-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q4SIW5        30 SKNMEGF-AGGNF-AANQCRNLMG------HPASLAPS------TAYSSCDVPASAIGEPVKQCSPCSAA-QNSSSASLP 94  spotted green p...
P50207        52 apSMDGL--GGSC-PASHCRDLLPhpvlarPPAPLGAPq----gAVYTDIPAPEAA-----RQCAPPPAP-PTSSSATLG 118 house mouse
Q3V600        31 SQTMEGL--SGNC-PATHCRDLMShpalgrHSGTIATHq----gSVYSDISSPDTG-----RQC---PAP-QSSSSASLS 94  Japanese medaka
ACL81457      31 NPGMEGL--SGNC-PATHCRDLIShpalgrHSSTIATHq----gPVYSDI-----AAPEAGRQC---PAP-QTSSSATLG 94  Menado coelacanth
XP_007248413  31 NPAMEGL--SGNC-PATHCRELIShpslgrHSGSLLSHq----gSVYPDIPAQDTG-----RQCP--AAP-QTSSGASLG 95  Mexican tetra
XP_002936691  31 SPAMEGL--SGNC-ASSHCRDFIShpalgrHSSAIGSHq----gPVYTDITSPEAA-----RQCT---AP-PSSSNASLG 94  western clawed ...
XP_004764951  12 AKAMEGLpGAG------GSRNLAArsplpsHPAAAGAPpllpaaVSYAPLDLPGSAEPP--KQCHPCPGVpQGTAPAAVP 83  domestic ferret
XP_002935723  10 qWEMEGLrGGGEGpSSNQCRNFLSspsvfgSPSSRTVPg-----LAYSAPDRSGSARAEAtKEGPTCPAS-TGPSGPSLG 83  western clawed ...
XP_004070510  31 SQTMEGL--SGNC-PATHCRDLMShpalgrHSGTIATHq----gSVYSDISSPDTG-----RQC---PAP-QSSSSASLS 94  Japanese medaka
XP_005995687  31 NPGMEGL--SGNC-PATHCRDLIShpalgrHSSTIATHq----gPVYSDIAAPEAG-----RQC---PAP-QTSSSATLG 94  coelacanth

Q4SIW5        95 YGYF-GSGYYPCRM--SHh----SSIKSCAaqSPSA----YGEKYMDTSA--T--SDDFP 139 spotted green pufferfish
P50207       119 YGYPfGGSYYGCRL--SHnv--nLQQKPCAy--------hPGDKYPEPSG--AlpGDDLS 164 house mouse
Q3V600        95 YGYPfGNPYYGCRL--SHshnvnLQQKPCSy--------hPAEKYAEPST--AlpSEELS 142 Japanese medaka
ACL81457      95 YGYPfGGTYYGCRL--SHshnvnLQQKPCSy----H----PAEKYAETssslpseelssr 144 Menado coelacanth
XP_007248413  96 CGYPfGSPYYGCRL--SHshgvnVQQKPCSy----H----PAEKYSEPSGtlP--SEELS 143 Mexican tetra
XP_002936691  95 YAYPfGSSYYGCRLsqSHnv--nLHQKPCSy----H----PAEKYPEPSNplP--SEEFS 142 western clawed frog
XP_004764951  84 YGYF-GGGYYSCRV--SR-----SSLKPCA--QAATlaayPAE----TAA--P--GEEYP 125 domestic ferret
XP_002935723  84 YGYHfGNGYYSCRM--SHgv--gLQQNPLKssSHASlggfPVEKYMDVSG--L------A 131 western clawed frog
XP_004070510  95 YGYPfGNPYYGCRL--SHshnvnLQQKPCSy--------hPAEKYAEPST--AlpSEELS 142 Japanese medaka
XP_005995687  95 YGYPfGGTYYGCRL--SHshnvnLQQKPCSy--------hPAEKYAETSS--SlpSEELS 142 coelacanth
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