Conserved Protein Domain Family
DUF3508
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pfam12018: DUF3508 (this model, PSSM-Id:314831 is obsolete and has been replaced by 463432)
Domain of unknown function (DUF3508)
This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is about 280 amino acids in length. This domain has two conserved sequence motifs: GFC and GLL. This family is also known as UPF0704.
Links
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Statistics
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PSSM-Id: 314831
Aligned: 53 rows
Threshold Bit Score: 140.014
Created: 27-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q28ZP3       222 NTSSAFQLALDGAAKMQSLcQAAIDEMIyld---------pkDTTMTYRVPLEHLQRLNQFTIIYTMQQRCLDALHRSYe 292 Drosophila pseu...
Q57VI3       221 SLREHIEKELEEAISACAR-YVAVLRSPst-----------pVEGSMREAICAEYHRQLQLLLNIRMAKQQLDTLNNQI- 287 Trypanosoma brucei
CDS39435     157 TTVETLDKQLKEVETYASL-FTSLYLKLaavdvn--tetqanVSAIEAKKMGISRSLLKAATINARQLAVYLRLIRRDLv 233 Echinococcus mu...
GAA27962     157 KTLSTLHDQLLKAREVAAR-NASLFMKLtahdpspgvlssanATIRAAEQSGVTPDLLRAVVINARQYEAFLEVLEKELi 235 Clonorchis sine...
XP_001987562 225 NTNAGFNAALERLKNLCDRcQTAVSDQLqfn---------ckETQLLYRVPLEQLHRINQFTVTFYMLQRCLTALKRSYe 295 Drosophila grim...
XP_002059457 225 NTSAAFDAVLERLKDLSGKcQAAISEQLqfn---------ckETTLYYRVPLEQLQRINQFTVTFNSLMRCLLELQRSYe 295 Drosophila virilis
XP_002063261 224 NTEEAFHTALKQASQMRSFcQMAVEENIkid---------anDMTLSYRVPLERLQRLNQFSLMYAMFYRCLNTLHLSYe 294 Drosophila will...
NP_611498    223 NTEAAFAASMGRAVKMQSTcQAALDDLInid---------hkDETLTYRVPLEHLDRLNQFAATYFMLHRCLTTLNEHYq 293 fruit fly
XP_001959181 223 NTETAFAASMEKANGVRNIcQALLEELVtid---------smAETISYKVPLEHMDRLNQFSLTYCMLHRCLTTLNSNYq 293 Drosophila anan...
XP_016665121 229 KVMMTTSWILQ-----CYKvYTEILAPIf------------vIRINFATVTIKKLNDYKTVLVFYLQYQKNLEIIKNDLn 291 pea aphid

Q28ZP3       293 stvylIEVERKRYECVVAKINDTLAMRT----------AIDSELIFPHF----VYISQVWSNLNNFLNHVV---ELNKLR 355 Drosophila pseu...
Q57VI3       288 -----FGELLPSYEAALEAVKDVLGTRSmrsdgvslrkNVSKATVYPKF----IELAEVYEEAQRSFQSFEdikALMTLS 358 Trypanosoma brucei
CDS39435     234 nlesgHREDKEKLVLVLGEILNCLRANQ----------N----TLHPSFqkhlLELSRLWMKFKENVTFIA---MLSNLL 296 Echinococcus mu...
GAA27962     236 gmtanVDRLCNIFRSQLKKLRELISDRL----------AIPSMEVYPRF----LELSATWSKLHDELTLLS---VLTSTL 298 Clonorchis sine...
XP_001987562 296 htaylVSVETGRYECVVAKINDTLSMRT----------SIQSELIFPHF----VYLSKVWSNLNHYFNHIV---ELNKLR 358 Drosophila grim...
XP_002059457 296 htaymVSVESGRYNCVIAKINDTLYMRS----------AIDSELIFPHF----VYLSKVWGNLNHYFNHIV---ELNRLR 358 Drosophila virilis
XP_002063261 295 ntkylVNVEQKRYQCVIAKINDTLSMRT----------AIESELIFPHF----VYLSQVWTNLNNFLNHIV---ELNKLR 357 Drosophila will...
NP_611498    294 ktvylIEVEHKRYQCVICKIDDTLSMRT----------AIDSELIFPHF----VYLSQVWGNLNNYLNHIV---ELNKLR 356 fruit fly
XP_001959181 294 ttaylIEVELKRYNCVVAKINETLSMRT----------AIESELIFPHF----VYIAQVWGNLNNFLHHIV---ELNKLR 356 Drosophila anan...
XP_016665121 292 klkieLPALLIKFNIILKEIKQ-LKNTN----------DFGEDTICPEF----NNVTIIWSEIRGIMNHLS---ITCNLI 353 pea aphid

Q28ZP3       356 EQLEILVpdqikdaaeatiaelqalhkriKVPQKIKFLDRIAVMtdyhtdg----------------------------n 407 Drosophila pseu...
Q57VI3       359 LSLGKVS----------------------NSSLPPTLLQEAINLekedgpadrcstearfesivtaslptkldrvfyard 416 Trypanosoma brucei
CDS39435     297 NSLQQFSfrry---------------vllEASRLLNLIHEAEVVcdemrkkattrvkpks----------edrsqwafpt 351 Echinococcus mu...
GAA27962     299 NTLQSFFvgrr---------------mkwTKEKEIHLISDAEFItddkikphgpiaeeprg--------pftwvypnsas 355 Clonorchis sine...
XP_001987562 359 EQLEQQVtkemthrakdtitqiqdlakrrKDWFECSFFERMDALkkyqtdg----------------------------n 410 Drosophila grim...
XP_002059457 359 EQLECQVpkemeqrakdtimeiqdlskhiKEMRECSFNERMELLkkyqtdg----------------------------n 410 Drosophila virilis
XP_002063261 358 EHLESLIpmdikslaestvaeilairqriKSDSVVSFDERMAALkmhqtdg----------------------------n 409 Drosophila will...
NP_611498    357 EQVEALVvddlmtltkatiaelqalhkriKKPKVCSFEERMDAVkelqtdg----------------------------n 408 fruit fly
XP_001959181 357 EQLEALVvddlvtmtkntiaelqalnkriKTPKVVTFDERMNAVkglktdg----------------------------n 408 Drosophila anan...
XP_016665121 354 LTMKQLTyeinniseein-nksimdtiltDTEELYTIFETYPLHpmcewhppt-----------------------tstd 409 pea aphid

Q28ZP3       408 fcnlaQAD----IKDFCALTLTItNGLLL--------PAKVSRKLCINVD----ITFGLRDHMYGRFTELCFEQFIPAFR 471 Drosophila pseu...
Q57VI3       417 aetlrARSavcaLNGMCPVTLLE-DGLCVegrvgsrdPAFPGFVMRSEVDnervEWYAFQTASKLLRFAASSQRFVDHAK 495 Trypanosoma brucei
CDS39435     352 pgsevKVD----LNGFCAWSIVRyQGLPI--------PCTPWIGVYVFEG----KKYGFSSVEAAMEFGSAPEKFVAELN 415 Echinococcus mu...
GAA27962     356 natnlSPE----LEGFCVFSLLKhQGLLV--------KGDMSLGLLITPDe--kRLYAFSSPEAVRDFLVVSDQLLQALP 421 Clonorchis sine...
XP_001987562 411 fcslaKAD----IKEFCGLTLAVtNGLLL--------PAKVQRKLCMNVD----IKFGFQDETYARIGELWFERFITALR 474 Drosophila grim...
XP_002059457 411 fcslaEAD----IKEFCGLTLAVtNGLLL--------PAKVLRKLCMNLD----IKFGFQDETYARIGELWFERFIIAFR 474 Drosophila virilis
XP_002063261 410 fcnlaRAD----INEFCALTLTItNGLIL--------PAHVQRKLCMNVN----ISFGFRDHRFARYAELRFEQFIEAFR 473 Drosophila will...
NP_611498    409 fcklnKAD----IKEFCSLAMTItNGLLM--------PAQVTRKLCSNVD----ITFGFRDPRYARFAELRFEPFIAAFR 472 fruit fly
XP_001959181 409 fcnlaKAD----IKEFCGLFMTMtNGLLM--------PAKVIRKLCSNMD----ITFGFRDPQFARFAELRFEHFIVAFR 472 Drosophila anan...
XP_016665121 410 dtrnlFAD------GYCVVMIVEtDGTLI--------KHDKSLGVIQYSD----EWFGFASIQAALHFGTKPTYYLYHFL 471 pea aphid

Q28ZP3       472 KVIFNSANLALLFKLD 487 Drosophila pseudoobscura
Q57VI3       496 TLVKSNMVMVGLFGLV 511 Trypanosoma brucei
CDS39435     416 EVVRNNPELIDLLSMA 431 Echinococcus multilocularis
GAA27962     422 TILRRLPELIQFLKLG 437 Clonorchis sinensis
XP_001987562 475 QAIFNSANLALLFKLD 490 Drosophila grimshawi
XP_002059457 475 QAIFNSANLALLFNLD 490 Drosophila virilis
XP_002063261 474 KVIFQNANLALLFHLD 489 Drosophila willistoni
NP_611498    473 KVVFNNANLALLFKLD 488 fruit fly
XP_001959181 473 SAVFNSANLALLFKLD 488 Drosophila ananassae
XP_016665121 472 NLMRSKTHLLSFFHLY 487 pea aphid
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