Conserved Protein Domain Family
Borealin
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pfam10512: Borealin (this model, PSSM-Id:313691 is obsolete and has been replaced by 463127)
Cell division cycle-associated protein 8
The chromosomal passenger complex of Aurora B kinase, INCENP, and Survivin has essential regulatory roles at centromeres and the central spindle in mitosis. Borealin is also a member of the complex. Approximately half of Aurora B in mitotic cells is complexed with INCENP, Borealin, and Survivin. Depletion of Borealin by RNA interference delays mitotic progression and results in kinetochore-spindle mis-attachments and an increase in bipolar spindles associated with ectopic asters.
Links
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Statistics
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PSSM-Id: 313691
Aligned: 34 rows
Threshold Bit Score: 84.297
Created: 27-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q9VLD6       187 RNSRSKLRTPM-ASRaka-----fsADRtplkq--------------kqmrSGSPTTPPMA------FLRYPKPGEVALS 240 fruit fly
Q7PSN3       219 RISRPKLRTPLpDGSrkgrttqavsADR-----------------------GMSQIMLKVEpntplaFIRYPRAGESVYS 275 Anopheles gambi...
Q16QC6       186 RTSRAKIRTPM-TNArka-----isVDR-----------------------IYGAITPKVQpnaplaLIRHARLGEPVYS 236 yellow fever mo...
Q7QHK0       203 RTSRSKLKSSLaTNRpka-----isADR-----------------------GYGVITPKVQpyaalaMIRHAKQGESVFS 254 Anopheles gambi...
Q16QC7       203 RLSRSKFRTPVpGSRlkq----tvsADR-----------------------GMTMITPKVQpntpmaIMRHARLGESIYS 255 yellow fever mo...
ETN66209     209 RLSRLKMRTPM-QET----------TKRargqa-------------vstdrGISQITLKVNlntpitFLRHPRVGESVFS 264 Anopheles darlingi
EFA07677     102 RQSRTKNRVPK-TTR----------ISRsqslrtknvtevyktpaqrvpanSYGTVTPKVKpntpqvLLRRPKQGEVALS 170 red flour beetle
ETN67187     200 RTSRAKHKTPM-IGRpka-----isADR-----------------------GYGVITPKVQpytplaLIRHAKLGESVFS 250 Anopheles darlingi
XP_001870165 208 RHSRSKFRTPNaAAGrlq----tvsTDR-----------------------GLSLITPKVQpntpmaLLRHARAGESIYS 260 southern house ...
XP_012545696 130 RRSRSVYRTPAcNKN----------AST-----------------------YYPAITPKVTpqtpltVLRQPRQGEMVVS 176 domestic silkworm

Q9VLD6       241 KYGSPMVAQ----VMPDKFANVNIPIRNG-VLSLRPKK-LdaDEVEsn-lLENLDEDTLNQIKTLHENLQMIVNK 308 fruit fly
Q7PSN3       276 LTGSPVVNT----VMSKNTANVNIPVPDG-MLSLQPTD-L--EDMDre-lLPKIDYATLEHLKKLQANLNKVMQY 341 Anopheles gambiae st...
Q16QC6       237 ITGSPVITS----NILEATANVNIPIENG-MLSIRPTE-M--DSVDpt-lVRKIDPNVLAELKQLQDNLNVIMRS 302 yellow fever mosquito
Q7QHK0       255 LTGSPVVTA----NMLESSANVNIPVSNG-MIAIRPTE-L--DVIDes-lIRKIDPNVLMELKQLQTNLDKIMST 320 Anopheles gambiae st...
Q16QC7       256 ITGSPVITA----AMVEEMANVNIPIQNG-ILSLRPTE-M--DSIDtg-lVQKIDSDTLEHLKKLQMNLNKIMQM 321 yellow fever mosquito
ETN66209     265 QSGSPVVNA----TAYRQTRHINIPVPNG-MLALQSDE-Lh-dEMVpe-mMPHLDSDTMDYLKG-RSRLQMVayk 330 Anopheles darlingi
EFA07677     171 LQGSPLLTGn---VVTDNVANINIPLEDGrLFSIQPQRgLr--VSQ----IPELDLETKRQLETLRDNLNKVCSl 236 red flour beetle
ETN67187     251 LTGSPVVTS----NMLEATANVNIPVANG-MLSIRPTE-M--DVVDet-lVRKIDANVLMEIKQLQSNLEKILNT 316 Anopheles darlingi
XP_001870165 261 MTGSPVITA----AMVEETANVNIPVANG-MLSIRPTD-M--ESFDag-lLQRIDPGTLEHLKKLQRNLNKIMQI 326 southern house mosquito
XP_012545696 177 MSGSPVMVPtcytMQPDEMANCNILLQDGtMLSLQPKQ-L--RQSQayipFSLMDTNVLNQLKTLKDNLDKVVKl 248 domestic silkworm
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