4OWW


Conserved Protein Domain Family
Ints3
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pfam10189: Ints3 (this model, PSSM-Id:313427 is obsolete and has been replaced by 431123)
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Integrator complex subunit 3
The Integrator complex is involved in small nuclear RNA (snRNA) U1 and U2 transcription, and in their 3'-box- dependent processing. This complex associates with the C- terminal domain of RNA polymerase II largest subunit and is recruited to the U1 and U2 snRNAs genes. This entry represents subunit 3 of this complex.
Links
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Statistics
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PSSM-Id: 313427
Aligned: 38 rows
Threshold Bit Score: 250.183
Created: 28-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4OWW_A        270 LWKDIIHNPQALspq-ftGILQLLQSRTSRKFLA-CRLTPDMETKLLFMTSRVrfg---qqKR----YQDWFQRQYLSTP 340  human
EPB87097      245 IWDDVVNHPQKLspk-fgGIQTMLNSPTPRDFLK-CRLTPDIEHKLLFILQNLrit---hfQK----NLNWFTQRFLSAP 315  Mucor circine...
XP_004365555  347 LWTDLIHRPTTLnah-fpGVKQILRTDTRARFLV-GRTTLDLESKLRFLLTTVkhg---elRR----YYQWFAKKYLEAP 417  Capsaspora ow...
CBY18143      242 FWATLLHNPNSLipk-fnGLQELLKIRTPTKFVK-LNISVELQNKISFILAKVrfg---qhLH----HEKWLSKQYLSSL 312  Oikopleura di...
GAA50283      224 LWDDILQNMPLLssh-fsSVADVLEITTPQCFTQ-TLIPHEMEQWARWMMKNVhcvprvpvNR----YQEFFQRKFFATP 297  Clonorchis si...
CTP82011      250 IWKQLLYNPNKLgpn--inIEELMNRMCPHTFPL-YRISVAMQRKLEFIFAKVkpg---thER----HLDWFKKQYLSNP 319  Brugia malayi
XP_006676969  235 LLLSIMQSPSPEypn-ipSLSDFLDRPTPREFLI-SRLTPDMEIRIVFILNSVp-------KRlsftFIEQFRKRFL-TL 304  Batrachochytr...
NP_001293424   85 IWKDIVANPASF------GVSNLEEYMTKQNVLQhVRISIELERKVQFMVVNGgk----nlLT----YFTWLNNKFFRAN 150  Caenorhabditi...
XP_002975151  229 IWRDLLANPASFrvpsftDIGQLYVVKTHTRYFQ-SRLTPEMEAQIKFMLTHVrmg---sqRR----YQGWFTQRFLSTP 300  Selaginella m...
NP_001293423  249 IWKDIVANPASF------GVSNLEEYMTKQNVLQhVRISIELERKVQFMVVNG--------GKnlltYFTWLNNKFFRAN 314  Caenorhabditi...

4OWW_A        341 DSQSLRCDLIRYICGVVHPSNEVLSSDILPRWAIIGWLLTTCTSNVAASNAKLALFYDWLFFSPDK-D-SIMNIEPAILV 418  human
EPB87097      316 ESEPFYVDVVRYLVAGWYPSNQILQSDIVPRYVVIGSMIRSIKSNIVAANVRTALIFDWLFFKP-T-D-NIMFIEPAMLL 392  Mucor circine...
XP_004365555  418 ESEAMLPDLIRYVCCAYHPTNEVLASDVAPRWMTISWLMWRAKSPTAMADVRLALFYDWMFFDPAR-S-NIMNIEPGILL 495  Capsaspora ow...
CBY18143      313 TSQTLLPDIMRFIVACVVPTNEILASDVLPRWAFCGYILSQCNNLQVTSATRLSLIWDWLLFNENR-N-TIMDIEPGLLL 390  Oikopleura di...
GAA50283      298 ESQSLRVCLLRYIVTFFYPDNEMLASTLIPRWNVISWILSQSTCAVVTANAKLALFYDWLFFKP-N-G-CIMNLEPALLA 374  Clonorchis si...
CTP82011      320 EAGSLRSELVR--CAIFLSCGEIPQVGQEMKAIFIASMFPQTNSIMEQQWCKLHLLWDWLCYDPAN-G-GHVLIEPAFHV 395  Brugia malayi
XP_006676969  305 ESETLLPDIIRYICGAIHPNNAILASDIVQRWHLISILLRGIKAPACAQSCKLSLYFDWLFFNHAS-D-SVMSLEPGILV 382  Batrachochytr...
NP_001293424  151 DGPALRAECVRYVLSMNLDPAKALPNAQENRVQLLHLLISTVPSGPELQWLKLCLFADWFGCDDKN-SaNLMCVENSFSV 229  Caenorhabditi...
XP_002975151  301 ESETLVCDLIRYVCCVHHPSNQILQSDILPRWALIGWLLKCCKSNHVEANAKLALLYDWLFFVPKT-D-NIMNIEPGILV 378  Selaginella m...
NP_001293423  315 DGPALRAECVRYVLSMNLDPAKALPNAQENRVQLLHLLISTVPSGPELQWLKLCLFADWFGCDDKNsA-NLMCVENSFSV 393  Caenorhabditi...

4OWW_A        419 MHHSM--------------KPHP-A-ITATLLDFMCRIIPNFY-PP-LEGHVRQGVFSSLNHIvEKRVLAHLAPLF---- 476  human
EPB87097      393 MERSA--------------ERYA-H-ITASLMQFLKRSVDEYF-PP-MKDYMSQCVACGMRVMlSKGVIRSLLPIY---- 450  Mucor circine...
XP_004365555  496 IQHML--------------NMNG-T-FAASLLEFVCLIATEFV-PS-LSSSITTSLRAAFYTCvSKRVIPSLSAIV---- 553  Capsaspora ow...
CBY18143      391 MQQSR--------------KIHP-Q-VTYGILDFLLRLVKEFY-PP-MEDEIRRGIVNSFRCCiKVGVAKSIEPILletq 452  Oikopleura di...
GAA50283      375 MMNHL--------------TPRT-QpIALSLVDFLVKIVGTYH-AP-MTDRIVAGVRSGLEEMiRLGVVKNINPLF---- 433  Clonorchis si...
CTP82011      396 LKHLL--------------HVQP-L-LANSLVDFMTRMSYELH-PQ-LQQRIITSVTNSFKFLiDHNILGSPSVIF---- 453  Brugia malayi
XP_006676969  383 MVKNL--------------QTSP-A-ISATMLEFLALIADRFL-PT-LSAHIYHNLKLSMSIVvEKRVITSLSLIL---- 440  Batrachochytr...
NP_001293424  230 VRYALfltptgpqqnsivqGSHCsQ-FANSLLEFLCKSVDVLL-PPaYAEPIRRNVNSAMRFI-KDRLQHNLPQIL---- 302  Caenorhabditi...
XP_002975151  379 MFQSI--------------PKYV-D-MTNSLLEFLFLLMEHYD-PP-RKELLHRGVAASVEILvGKGVVRNLEPLA---- 436  Selaginella m...
NP_001293423  394 VRYALfltptgpqqnsivqGSHC-SqFANSLLEFLCKSVDVLLpPA-YAEPIRRNVNSAMRFI-KDRLQHNLPQIL---- 466  Caenorhabditi...

4OWW_A        477 D-NPKLDKELRAMLREKFP 494  human
EPB87097      451 R-CPATDQVTRDYMQALFS 468  Mucor circinelloides f. circinelloides 1006PhL
XP_004365555  554 N-HTSIDEPLRDKFNTTFP 571  Capsaspora owczarzaki ATCC 30864
CBY18143      453 R-YASITPCLHNMIQLNLQ 470  Oikopleura dioica
GAA50283      434 EmLHRTSPDLLRALRSLLg 452  Clonorchis sinensis
CTP82011      454 D-NPVLQKNVRENFRDTFR 471  Brugia malayi
XP_006676969  441 L-SPQLDEFTKETVTKLFa 458  Batrachochytrium dendrobatidis JAM81
NP_001293424  303 E-NSKIDRKVSELLRNVFP 320  Caenorhabditis elegans
XP_002975151  437 T-APAIALPLREKLsql-- 452  Selaginella moellendorffii
NP_001293423  467 E-NSKIDRKVSELLRNVFP 484  Caenorhabditis elegans
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