Conserved Protein Domain Family
WTX

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pfam09422: WTX (this model, PSSM-Id:312801 is obsolete and has been replaced by 462794)
WTX protein
The WTX protein is found to be inactivated in one third of Wilms tumors. The WTX protein is functionally uncharacterized.
Statistics
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PSSM-Id: 312801
Aligned: 15 rows
Threshold Bit Score: 435.441
Created: 26-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
E1C2Q8         57 GMVRSRTHDGL-ADA-VLESGKKEDagggea-----qgkdapS------------------------RAAGGLGGSASSS 105  chicken
Q5JTC6         89 GLSKSKTHDGL-SEAaHGPEDVVSE-----------------G------------------------TGFSLPLPELPCQ 126  human
F1QGH6         60 ELVRSKTHDGLiTDTpSELDSHRKEesass-------dqlhaG------------------------TPDGVSTAPLRSS 108  zebrafish
Q8CCJ4         94 GMVRSRTHDGL-AEVlVLEGSKKEEppggsdhsgarpipgppK------------------------PSGPGLGSLASSS 148  house mouse
XP_007252366   59 ELARSKTHDGLvTDVpSDLEGSKKEdscssdll-------------------------------hsapvegvSLAPVRSA 107  Mexican tetra
XP_015354321  101 GMVRSRTHDGL-AEVvVLEGSk--------------------KeepraggdsgrgrgggrpnpgpprAAGTGVGSLANSS 159  Alpine marmot
CAF94426       74 EIIRSKTCDGL-MSSnSDADGQR-E-------------------------------------------GLASLEAGPVRS 108  spotted green...
XP_005803382   77 ELVRSKTHDGL-TGSnNEAVGQRGE-------------------------------------------GLTSLEAGPVRS 112  southern plat...
XP_005471779   77 ELVRSRTHDGL-TSSnNDADGQRGE-------------------------------------------GLAGLEVGPVRS 112  Nile tilapia
XP_004872318   89 SLRKSKTHDGL-SEVaHGPKD-VSE-----------------G------------------------TGFSLPFPESPCR 125  naked mole-rat
E1C2Q8        106 VAKSHSFFSLLR-----KNGRPENGKAAENAEQRAGGRQKKGLKGIFSSMRWHRKDKIGKEERGE----ASEipsg---- 172  chicken
Q5JTC6        127 FPSSQSAHGALEtgsrcKTSVAGATEKAVAEKFPSMPKPKKGLKGFFSSIRRHRKSKVTGAEQSEpgakGPE-------- 198  human
F1QGH6        109 ITKSFSFFSLLR-----RSSSRAGDGT------TTVGRRGRGLKGLFSSMRWRRKPQIQEDTle---vaKEVkegdlils 174  zebrafish
Q8CCJ4        149 VAKSHSFFSLLK-----KNGRSETGKGDHAEASKAGGKQKRGLKGIFSSMRWHRRDKRGKEEEEKa--vRAAgpgn---- 217  house mouse
XP_007252366  108 ITKSFSFFSLLR-----RNSTRVGDGAA------TLGHRGRGLKGLFSSMRWRRKPPPREDSSEIqevaKEVkegdvilp 176  Mexican tetra
XP_015354321  160 VAKSHSFFSLLK-----KNGRSENGKGDPADASKAGGKQKRGLKGIFSSMRWHKKDKRGKEEEKEa---HAAgqgs---- 227  Alpine marmot
CAF94426      109 LSKSLSFFSLLR-----RGSFKSSEGGG-----SGLVRRGRGLKGFFSSMRWRRKDKSNEKEIEElvgkRKEdgki---- 174  spotted green...
XP_005803382  113 LSKSLSFFSFLR-----RGSFRTSENGG-----TGIVRRGRGLKGFFSSMRWRRKEKTSEAEGEEvegkKARdtdat--- 179  southern plat...
XP_005471779  113 LSKSLSFFSLLR-----RGSFRSSENGG-----AGLVRRGRGLKGFFSSMRWRRKDKTNEGDGEEaeakKDKdgdaa--- 179  Nile tilapia
XP_004872318  126 FPSSQSAHGALEidyrhKKSVAGSTKKAGVDKLPPVPKPKKGLKGFFNSIRRHRKSRIAGAEQSEpnakASE-------- 197  naked mole-rat
E1C2Q8        173 ------limpG--SLTASLECIKEETPKPLSEtpngagDTGVESQQEKRGGDAC--VSAEEPqa------gGGESRDSKT 236  chicken
Q5JTC6        199 ----------R--VRARPHEHVSSAPQVPCFE------ETFQAPRKENANPQDApgPKVSPTpe-----psPPATEKMAC 255  human
F1QGH6        175 s-ssgsvkteK--DMTLTLEPLPQVFEESPLPgdsdkwKVASMQGIQGTNEVECgnCGPSVSqq---------------- 235  zebrafish
Q8CCJ4        218 ------lvlpG--SLTASLECVKEEPPRAARRpdspgqDASRHAAGEPAGGEQAp-ASAESApericleagSPTGSGDQS 288  house mouse
XP_007252366  177 stsnkvetleD--SVTLTLEPTVRVFEECPTEdnsgtwDKNSLEEVKSSNEE----------------------SRKSSC 232  Mexican tetra
XP_015354321  228 ------lilpG--SLTASLECVKEETPRAACEpetpsqDAPRDPAGELGGGEEVpaSA-DRApartcreaeSPGCPNDKS 298  Alpine marmot
CAF94426      175 ------ddseKlkDVTLTLEP----------PphhhheDCGDAGTEPN---TETpsTSVTLTpsqc-vagsEPSAELDS- 233  spotted green...
XP_005803382  180 -----esetlK--DITLTLEP----------PphhhqeDCASAETGSNLQASDTptTSVTMTpthc-vampGPSGEPDS- 240  southern plat...
XP_005471779  180 -----daekvK--DITLTLEP----------PphnhqaDCGDAEAGPNLQALETptTSVTMTpphc-vampGPSGEPDS- 240  Nile tilapia
XP_004872318  198 ----------G--ARARSHEHVSSSP-LPCSE------ETCQATTKENAKPQAVlgPKISPApe-----psSPATEKIAC 253  naked mole-rat
E1C2Q8        237 PPGEDpaAAARRLEELCGERPDPGAGEVGTAKDAAITGDIpittippvephc--dsgqetaaapdpSS--VDPPSEQSID 312  chicken
Q5JTC6        256 KDPEKpmEACASAHVQPKPAPEASSLEEPHSPETGEKVVA--------------------------GE--VNPPNGPVGD 307  human
F1QGH6        236 -----htVTEESPAPSPLRVQTGGLQNHKHSSSTHLSSIPtcalt----------------ppmehST--ADPQSEQSVD 292  zebrafish
Q8CCJ4        289 SRGED--AEGHRREEKPGAALESGAGEVQAAEDASKTGDVpiktvplvdseg---gsgrasavpdpSS--VDPPSDPSAD 361  house mouse
XP_007252366  233 SLVQE--ITEESPAPSPLRVPTEGPLRANTSGSACLTSIPasamt----------------pplehSS--VDPPSEPSVD 292  Mexican tetra
XP_015354321  299 ARGED--AAGHRRAEKPRAPPESGAGEVHTAEDASRTGDVpiktvplvdsec--gsgrasavpdpsS---VDPPSDPSAD 371  Alpine marmot
CAF94426      234 -------PFPYTPTDSPLRPPI-------QKTKASISSLTpslatp---------------pldrcST--GDPPSEPSVD 282  spotted green...
XP_005803382  241 -------PFPYTPTDSPLRPSI-------QKAKASISSLTpslttppldrcsigdqpsepsvdrlcSIlfTDVTSLKSFD 306  southern plat...
XP_005471779  241 -------PFPYTPTDSPLRPPI-------QKAKASISSLTpslatp---------------pldrcST--GDPPSEPSVD 289  Nile tilapia
XP_004872318  254 KNLEKsiGISASPLVLPKLAPESSILEESHR-QTGEKIIA--------------------------GE--LNPPNGPMGD 304  naked mole-rat
E1C2Q8        313 RI--C-LMFADV-----------------TSLKSFDSLTGCGDIIA------------------------DQEEDVGggs 348  chicken
Q5JTC6        308 PL--S-LLFGDV-----------------TSLKSFDSLTGCGDIIA------------------------EQDMDSM--- 340  human
F1QGH6        293 RL--C-SMFTDV-----------------TSLKSFDSLTGCGDIIA------------------------DPEEDSGngg 328  zebrafish
Q8CCJ4        362 RI--C-LMFSDV-----------------TSLKSFDSLTGCGDIIA------------------------DPEEEAG--- 394  house mouse
XP_007252366  293 RL--C-SMFTDV-----------------TSLKSFDSLTGCGDIIA------------------------DQEEDSG--- 325  Mexican tetra
XP_015354321  372 RI--C-LMFSDV-----------------TSLKSFDSLTGCGDIIA------------------------DQEEEAG--- 404  Alpine marmot
CAF94426      283 RL--CsLLFTDV-----------------TSLKSFDSLTGCGDIIA------------------------DADDEg---- 315  spotted green...
XP_005803382  307 SLtgCgDIIADAdeegpggnggsgtssssSGGGGGSLSTNVGRAVGltsatthasptkppipsqitqpmfSVPQ------ 380  southern plat...
XP_005471779  290 RL--CsLLFTDV-----------------TSLKSFDSLTGCGDIIA------------------------DADEEg---- 322  Nile tilapia
XP_004872318  305 QL--S-LLFGDV-----------------TSLKSFDSLTGCGDIIA------------------------EQDMDSM--- 337  naked mole-rat
E1C2Q8        349 GGCEKST----------------PGAGKLGA----PKK------------------------------------------ 366  chicken
Q5JTC6        341 TDSMASG----------------GQRANRDG----TKR------------------------------------------ 358  human
F1QGH6        329 SATSSGT----------------GSSSGGCM----GRRlsgagtnsercspakpplppqvss-----------lasihas 377  zebrafish
Q8CCJ4        395 PSCDKHV----------------PGPGKPVL----SKK------------------------------------------ 412  house mouse
XP_007252366  326 NGGSATSsgtgsssggcggrrviGAATERCS----PVKpplppqvtsrvsispy-------------------------- 375  Mexican tetra
XP_015354321  405 PSCDKHA----------------PGPGKPVL----SKK------------------------------------------ 422  Alpine marmot
CAF94426      316 PS----------------------------VpsslPARarapps------------------------------------ 331  spotted green...
XP_005803382  381 ------------------------SSAPVCL----PARtrvppp------------------------------------ 396  southern plat...
XP_005471779  323 PVGNGGS----------------GTSSSSSG----GGGgsvgvgigrvvgitssispskpplssqmsqpmfsvsqnsapa 382  Nile tilapia
XP_004872318  338 TDSMASG----------------GQRANRDG----TKR------------------------------------------ 355  naked mole-rat
E1C2Q8        367 -----------------HPTMVAYQGGGEEMASPD-----------------------QVDDTYLQEFW---DMLSQTEE 403  chicken
Q5JTC6        359 -----------------SSCLVTYQGGGEEMALPDdddeeeeeeeeveleeeeeevkeEEEDDDLEYLWetaQMYPRPNM 421  human
F1QGH6        378 cympahqrpraapkkpqGSGVVAYMGGGEEMASPE-----------------------GVDDADMQGLW---HMLPQKDE 431  zebrafish
Q8CCJ4        413 -----------------NASVVAYQGGGEEMASPD-----------------------QVDDTYLPEFW---DMLSQTED 449  house mouse
XP_007252366  376 --lsshqrmssspkkpqGSGIVAYMGGGEEMASPE-----------------------GVNDADMQGLW---HMLPQKGE 427  Mexican tetra
XP_015354321  423 -----------------NPSVVAYQGGGEEMASPD-----------------------EVDDTYLQEFW---DMLSQTED 459  Alpine marmot
CAF94426      332 -----------pqhhppGSGVVAYMGGGEEMASPE-----------------------GVDDADMQGLW---HMLPSTGD 374  spotted green...
XP_005803382  397 -----------pqqhsaGSGVVAYMGGGEEMASPE-----------------------GVDDADMQGLW---HMLPSAGE 439  southern plat...
XP_005471779  383 slpartraqpqpqqhppGSGVVAYMGGGEEMASPE-----------------------GVDDADMQGLW---HMLPSTGD 436  Nile tilapia
XP_004872318  356 -----------------SSCLVTYQGGGEEMALPDddeeeedev-----eleeeeevkEEDDDDLEYLWanaQMYPRPDF 413  naked mole-rat
E1C2Q8        404 TetgGGGGGGGGTKT------------PEGLKENRGTegaqnrvavkrggln----------------------qipihl 449  chicken
Q5JTC6        422 N---LGYHPTTSPGHhgymlldpvrsyPGLAPGELLT------------------------------------------- 455  human
F1QGH6        432 D-------SPAPRRAepv------lhhAPArlekrppqvkalglskip----------------------vsgssktgkq 476  zebrafish
Q8CCJ4        450 Q---GQGTQEGAAKAatasd---iklaPETSSDTRCGeaakdmssvkrrrlh----------------------ripies 501  house mouse
XP_007252366  428 D-------SPALPRSdpi------vhhPPGrqekkhpqvkslglskip----------------------vcgisktgkq 472  Mexican tetra
XP_015354321  460 Q---GQGPQEGAAKAaaale---tkvvPETSKDARSVeaskdvslvkrrrlnr--------------------ipieshp 513  Alpine marmot
CAF94426      375 N-------SPALPRShqlpsstptstyPPRATSGLPSsylpsgprsvdrkqsqvktlglskipvvggattkagktplsha 447  spotted green...
XP_005803382  440 S-------SPALPRQyqpssstltstyPPR--SNSPSalrpsaqrsaerkapqvkslglskipvvggagsragkpplpha 510  southern plat...
XP_005471779  437 N-------SPALPRShqpssstptstyPPR--TNPASsylpsasrssdrkvpqvkalglskipvvggagsraakpplpha 507  Nile tilapia
XP_004872318  414 N---LGYHSTTSPAHhgymlldpvqsyPGLAPGELLT------------------------------------------- 447  naked mole-rat
E1C2Q8        450 nnkeeqkgREKEQHEGVPNSDEGYWDSTTPGPE---EDS---TTSIQKETLPRDSYSGDALYDLYaEPDENPPGGPP--- 520  chicken
Q5JTC6        456 --------PQSDQQESAPNSDEGYYDSTTPGFE---DDSgeaLGLVRRDCLPRDSYSGDALYEFY-EPDDSLENSPP--- 520  human
F1QGH6        477 qpsrpsppPVDKELQDAPPSDEGYWDSPTPGPE---DED---STFLRRDGLLRDSCSGDALYDLY-DPDSPSAAGSD--- 546  zebrafish
Q8CCJ4        502 qqkeepkhPEKEHQEGVPNSDEGYWDSTTPGPE---EESisnSSSSKKVVIPRDSDSGDALCDLYvEPEASPATLPA--- 575  house mouse
XP_007252366  473 qsahpsppPTDKELHDAPPSDEGYWDSPTPGPE---DED---NGFTRRDGLLRDSCSGDALYDLY-DLDSPGAGGSD--- 542  Mexican tetra
XP_015354321  514 keqpkhpeKEKEQQEGVPNSDEGYWDSTTPGPE---EES---ASSGKKAGIPRDSYSGDALYDLYaDPDGSPAVPPA--- 584  Alpine marmot
CAF94426      448 hghnvtspGEKE-----PLRDEGYWDTPSATPTatpDDSg--LQQNQRIGLSRDSCSGDHLYDLYnDPEEEGEGCEQe-- 518  spotted green...
XP_005803382  511 hgrhpvspGEKE-----LLSDEGYWDTPSATPTatpDESg--LQRNQKIALSRDSCSGDHLYDLYnDPEEEGED--Qrgd 581  southern plat...
XP_005471779  508 hgrhptspSEKE-----PLSDEGYWDTPSATPTatpDESg--LQHNQNMALSRDSCSGDHLYDLYnDPEEEAED--Qggd 578  Nile tilapia
XP_004872318  448 --------PQSDQQESAPNSDEGYYDSTTPGFE---DDSgeaLGLVHRDCLPRDSYSGDALYEFY-EPDDTLENSPP--- 512  naked mole-rat
E1C2Q8        521 EEE-VTCMPRSK-PVS 534  chicken
Q5JTC6        521 GDD-CLYDLHGR-SSE 534  human
F1QGH6        547 -DD-ASSPTKSAgDLK 560  zebrafish
Q8CCJ4        576 TED-PPCLSRLK-PVS 589  house mouse
XP_007252366  543 DDDnMSSPTPSTgdlk 558  Mexican tetra
XP_015354321  585 NEE-TSCLSRLK-PVS 598  Alpine marmot
CAF94426      519 GQS-QSSLSPAS-ECK 532  spotted green pufferfish
XP_005803382  582 NDV-NSTPSPSA-EFK 595  southern platyfish
XP_005471779  579 EDP-NSSPSPST-EYK 592  Nile tilapia
XP_004872318  513 EDD-CLYDLHGH-SSE 526  naked mole-rat
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