Conserved Protein Domain Family
RabGGT_insert
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pfam07711: RabGGT_insert (this model, PSSM-Id:311580 is obsolete and has been replaced by 462239)
Rab geranylgeranyl transferase alpha-subunit, insert domain
Rab geranylgeranyl transferase (RabGGT) catalyzes the addition of two geranylgeranyl groups to the C-terminal cysteine residues of Rab proteins, which is crucial for membrane association and function of these proteins in intracellular vesicular trafficking. This domain is inserted between pfam01239 repeats. This domain adopts an Ig-like fold and is thought to be involved in protein-protein interactions and might be involved in the recognition and binding of REP.
Links
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Statistics
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PSSM-Id: 311580
Aligned: 10 rows
Threshold Bit Score: 153.351
Created: 21-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
NP_001006728 243 IRCVMVSLDEPCVSVTFSHPVEV---QEDLILFLNN-RPIFVSWRTAGRKEKRSLFWVCDLPKECINDPCCQY-NFQVLW 317 western clawed ...
XP_002607448 243 IRCLHVCRPLNRLVATFSKHLKAs--AATLNVVKDG-EVITGRWHTPRGTDTFEQVLIFEFPEHSLTPDRDQHiHVTLDT 319 Florida lancelet
XP_007233482 266 ISCVYVSREGERVAVAFSKPVNAl--TEGLMLVLDGqQQQRVEWRSAHPRFRHSPVWLCELPPGSVSDINNEH-NLTVHW 342 Mexican tetra
NP_001070131 260 ISCVYASREGERVSVAFSKPVHAg--SVGLMLVLDG-QPQQVQWRNAHPRLRHSPVCLRDLPAGSISDTSNEH-NLTIHW 335 zebrafish
XP_010729388 285 ISCVYVSRDEERVAVAFSRPVNAq--SVGLLLVLDG-QPQRVEWRSVHPRFKHSPVWICDLPPGTISDITNEH-NLTVHW 360 large yellow cr...
XP_008533653 245 LRCLHVSRDEACLTVSFSRPLLVgs--gTLLLMVDE-SPLAVEWRTPDGRNRPSHVWLCDLPAASLNDQLPQH-TFRVIW 320 Equus przewalskii
XP_003755932 245 IRCLHVSRNEACLTVCFSRPIIVgpgIETVMLLVDE-SPLPVEWRTPDGKKRPNHVWLCDLPADSFNDQDSQH-SFFLMW 322 Tasmanian devil
XP_001515941  17 VLCLHVSRDDACLTVGFSRPLAVgpgAERLLLLVDE-SPLAVEWRTPDGRNGPGNVWLCDLPAAslNDQWPQH-TFRLLW 94  platypus
XP_016852482 127 IRCVYVNREDTSLAVAFSHPVAIapaSHDLIIFGDE-SPLVVRWRTPDGRNRPGFMWLCDLPASALNDHWPQH-TFRILW 204 green anole
XP_011472015 171 ISCVYVSREDERVAVAFSRPINAr--CVGLLLVLDG-QPLRVEWRSVHPRFRHSPVLICDLPPGTINDVTNEH-NLTVHW 246 Japanese medaka

NP_001006728 318 KDGEAKKECILYPGRRESW 336 western clawed frog
XP_002607448 320 EAGLVGRECVLGAGHPEVF 338 Florida lancelet
XP_007233482 343 MEKHTHRDCALYTGRPESW 361 Mexican tetra
NP_001070131 336 TDKHTHRDCALYTGCAESW 354 zebrafish
XP_010729388 361 TEKHTHRDCALYTGRTESW 379 large yellow croaker
XP_008533653 321 TAGDAQKECVLFKGRQETW 339 Equus przewalskii
XP_003755932 323 --GDVQKECVLYKGRKESW 339 Tasmanian devil
XP_001515941  95 RGGDAQKECVLFKGRREGW 113 platypus
XP_016852482 205 SEGQSQKECVLFKGHRDCW 223 green anole
XP_011472015 247 TGNHTHRDCALYTGRVESW 265 Japanese medaka
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