Conserved Protein Domain Family
FAST_1
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pfam06743: FAST_1 (this model, PSSM-Id:310980 is obsolete and has been replaced by 461999)
FAST kinase-like protein, subdomain 1
This family represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases (EC:2.7.1.-) that contains several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis. Note that many family members are hypothetical proteins. This region is often found immediately N-terminal to the FAST kinase-like protein, subdomain 2.
Links
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Statistics
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PSSM-Id: 310980
Aligned: 135 rows
Threshold Bit Score: 45.5305
Created: 21-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q16XE8       415 RAIFCPFGYLDYQPV--NsnKFWETLDMYLDLNFTKIHPMEIIDIMFSYVSLERYPL-MFVNRIFNPYFLDV 483  yellow fever mosquito
XP_002411711 354 VNMVRAFGYLNLTPK--NpmGFFGSLEWLLREKFNVFRPDHLVEILVACVYLQRYPL-NFVKKVFSPYFLDR 422  black-legged tick
EFN68880     533 SSMLTPFGLLNIQPP--DptEFWKKFDEVISARFADLKLNDVLDIFLSCMYLEKYPV-KYLDRVFSSYLVNR 601  Florida carpenter ant
EFZ21923     348 SPILTPFGLLNLQPP--DssEFWKTFDEVMSVRFSDLKLNDALDIFLSCTYLERYPI-KLLDKVFSSYLMNR 416  red fire ant
XP_002602981 398 ASQIVPYGQLNYLPP--NayRFLEKVEQLLMARYHLFPLEMMVNMLFSFACVGRIPL-NFVNRVCSPYaelq 466  Florida lancelet
XP_013121503 479 QKLVFPFSRMSYRPS--NeqQFFSRLEEVVELKALS-SPLATVNILMSLFQLGHFPG-LVLHRVFSSAFISN 546  Nile tilapia
XP_008122664 206 qrLVFPFGRLDYRPA--NhqELFPRLVGSLGQAGPSPSPLAVLNVLLTLCQLQFWPPaALLQRVFSPAFLAN 275  green anole
EHJ69273     330 kSFIYTYGYLSYQPK--Ns-dFWPAAERVLLEKYNKMKIEDLTDIILSFMYCGQYPL-KLVQNVFKIEntsk 397  monarch butterfly
XP_009024727 417 lSVLKSFGQLGYIPSstSssEFFSAAEHWTQQKLNRIPFSDLLELLASFVYIERFPV-NFVDRVLNAQikdp 487  Helobdella robusta
EMC84927      10 QKLVFPFSRMNYRPS--NhsELFPKLEAILEQKAGS-SPLATVNILMSMFQLSHFPQ-TVLHQVFSPAFITN 77   rock pigeon
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