Conserved Protein Domain Family
PV-1
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pfam06637: PV-1 (this model, PSSM-Id:310914 is obsolete and has been replaced by 461970)
PV-1 protein (PLVAP)
This family consists of several PV-1 (PLVAP) proteins which seem to be specific to mammals. PV-1 is a novel protein component of the endothelial fenestral and stomatal diaphragms. The function of this family is unknown.
Links
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Statistics
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PSSM-Id: 310914
Aligned: 10 rows
Threshold Bit Score: 624.9
Created: 26-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q9BX97         1 MGLAMEHgGSYARAG-----GSSRGCWYYLRYFFLFVSLIQFLIILGLVLFMVYGNVHVSTESNLQATERRAEGLYSQLL 75  human
Q91VC4         1 MGLSMDR-SPYARTG-----DQQRGCWYYLRYFFLFVSLIQFLIILGLVLFMIYGNVHATTESSLRATEIRADSLYSQVV 74  house mouse
XP_006768478   1 MGLAMEHgGAYTRAA-----GSSRGCWYYLRYFFLFVSLIQFLIILGLVLFMVYGNVHESTESNLQATKHRAESLHNQLQ 75  Myotis davidii
XP_541953      1 MGLPVEHgGAYARAG-----GSPRGCWYYLRYFFLFVSLIQFLIILGLVLFMVYGNVHVSTESNLQATERRAEGLYSQVV 75  dog
ELR46074       1 MGLAMEHgSPYSRAG-----SSSRGCWYYLRYFFLFVSLIQFLIILGLVLFMVYGNVHVSTESNLQATERRADGLYGQVV 75  Bos mutus
XP_003464240   1 MGLAMQPgAPYTRAG-----GSARGCWYYLSYFFLFVSLIQMLIILGLVLFMVYGNVHEGTEANLQDTExRAAALHAQVV 75  domestic guinea...
ELW67180       1 MGLPMEHgGAYARAG-----GSPRGCWYYLRYFFLFVSLIQFLIILGLVLFMVYGNVHVSTEDNLQATERRAEGLFSQVV 75  Chinese tree shrew
XP_012664866   1 ----MDRgGAYSRAG-----GSPRGCWYYLRYFFLFVSLIQFLIILGLVLFMVYGNVHVSTESNLQATERRAGDLYSQVL 71  small-eared galago
XP_003760899   1 ----MDRsSSYSRTGlhissSENRGCWYYLKYFFLFVSLIQFLIILGLVLFMVYGNAHAGTEAHLEVTEKRADTLSGRLL 76  Tasmanian devil
XP_005333070   1 MGLAMEHrGAYSRAG-----DSPRGCWYYLRYFFLFVSLIQFLIILGLVLFMVYGNVHLSTESNLQATERRAESLYSQVV 75  thirteen-lined ...

Q9BX97        76 GLTASQSNLTKELNFTTRAKDAIMQMWLNARRDLDRINAS-FRQCQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSC 154 human
Q91VC4        75 GLSASQANLSKQLNISLLVKETVMQQLLTTRREMERINAS-FRQCQGDLITYINYNRFIAAIILSEKQCQEQLKEVNKTC 153 house mouse
XP_006768478  76 GLSASHANLTKELNLTARAKESIMQMLLVARREVDRINAS-FRQCLADRNVYMNNQKYMAAIILSEKQCQEQLKETNNSC 154 Myotis davidii
XP_541953     76 GLTASQANLSKELNLTSRAKETIMQLLLNARRDLDRINASfCQ-CQADRVVYMNNQRYMVAIILSEKQCQEQLKETNKSC 154 dog
ELR46074      76 GLTASQANLTKELNLTARAKEAINQMMLSARRDLDRINAS-FRQCQADRVIYMNNQRYMAAIILSEKQCQEHLKEANKSC 154 Bos mutus
XP_003464240  76 GLAGARANLTRDLNLTARAKDAIMQMLLSTRRDLDGLNNS-FRQCQADRVTYTIHQQYMAAIIQSEQQCQEQLKTDNKTC 154 domestic guinea...
ELW67180      76 GLTASQTNLSKELNLTSRAKDAIMQMLLSARRDLDRINAS-FRQCQGDRIIHANNQRFMAAIILSEKQCQEQLRESNKTC 154 Chinese tree shrew
XP_012664866  72 GLMASQTNLSKELNLTSRAKDSIMQMLLSARRDLDRINAS-FRQCQSERVIHTNNERYVAAIIVSEKLCQDQLKEMNKSC 150 small-eared galago
XP_003760899  77 NLGALNTNLSKELNITTRSREAIMQLLVGSRRDLDRINAS-YRQCQVDVNQHENNMKFVVAIVKSEEACRQQLAEHLRNC 155 Tasmanian devil
XP_005333070  76 GLSAAQVNLSKELNITARTKDNIMQMLLSARRELERINAS-FRQCQSERAVYISREKYIVAIILSEQECQEQLKQANKSC 154 thirteen-lined ...

Q9BX97       155 DALLFMLNQKVKTLEVEIAKEKTICTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFE 234 human
Q91VC4       154 EALLFKLGEKVKTLEMEVAKEKAVCSKDKESLLAGKRQTEEQLEACGKARERQQQEQQVTEENLRKVQSLCIPLDQEKFQ 233 house mouse
XP_006768478 155 NALLLELNQKTKTLELELAKEKAVCAKDKEGLGLSKRIVEEQLAECGKAREQQRQERQLAESHLQKVQSLCLPLDKDKLA 234 Myotis davidii
XP_541953    155 NALFLMLNQKAKTLEMEVAKEKQVCTKDKEALVLSKRVVEEQLAECGKAREQQRQERQLAEDRLQKVQTLCLPLDKDKFE 234 dog
ELR46074     155 DALALTLTQKAKTLEVELAKEKLVCTKDKDGLTVGKRVAEEQLAECGKTRDQQQQERQLAEDRLRKVQAFCIPLDRNKFE 234 Bos mutus
XP_003464240 155 HDRFFVLEQKIKVLEMEMAKDKALCSREKEALALARHQVETQRSECERAQGQLAQQKQLSEERLQQVQALCAPLDRNRLE 234 domestic guinea...
ELW67180     155 DALLLMLGQKAKTLEVELAKEKAVCTKDKESSSLSKRVVEDQLAECGKAREQLRLERQLVEGRLQKVQSVCLPFDKEKFE 234 Chinese tree shrew
XP_012664866 151 EALHLRSGEMAKKLEVELVKEKVVCTKDKEGLLLSKNVMEEQLTQCSKAQEQHQQERQLAEDKLQKVQSLCFQLDKDKFE 230 small-eared galago
XP_003760899 156 TAQIQALEEKAKTAQAVQETLKMACNKDKESLMAAKGLVESQFKACSAEKMSNFGEYQLVVGELQRVRDMCAAVDKEKLV 235 Tasmanian devil
XP_005333070 155 NALLYVWDQKAKALEMELAKEKVVCAQDKEGLLASKRAAEQQLVACNQVREQQQQERQLAQDRLQKVQALCLPLDKDKFE 234 thirteen-lined ...

Q9BX97       235 MDLRNLWRDSIIPRSLDNL----GYnlYHPL--GSELASIRRACDHMPSLMSSKVEELARSLRADIERVARENSDLQRQK 308 human
Q91VC4       234 ADVLSAWRDSLIYRTLETL----PY--HYQL--MPEYASLRRTCESLPGIMTTKIEELARGLRAGIERVTRENAELRRQK 305 house mouse
XP_006768478 235 VDLRNLWRDSIIPRTLDAL----TYspYHPM--GSDLVSIRRICDQMPNMMRTKVEELAQSLRSGIQRVAQENADLQRQK 308 Myotis davidii
XP_541953    235 TELRNLWRDSIIPRTLDTM----SYnlYHPL--GSEITSIRRSCDHMPTLMSTKVEELARSLRAGIERVARENADIQRQK 308 dog
ELR46074     235 TDLRNLWRDSIIPRTLSTL----SFnlYHPL--GSELPSIQRACDSLPSIMTSKVEELARSLRAGIDSVTLENEKLQRQK 308 Bos mutus
XP_003464240 235 TELRMVWRDSVIARALDNLnfgaGYsmYHGP--GTDPVSLRRACDQLPAIMATKSEELAQRLRADIERVARENERLHAQK 312 domestic guinea...
ELW67180     235 TDLQNLWRDSIIPRTLDTF----GYglYSHI--NPELNSIRRTCDHMPTLMASKVDELARSLRSGIERVARENSDLQRQK 308 Chinese tree shrew
XP_012664866 231 NDLRNLWRDSIIPRTLDSL----SYgvYHPL--GSDILSIQRMCNQLPSLMSTKVEELARSLRASIESVARENSDLQRQK 304 small-eared galago
XP_003760899 236 SKMEQVWRESLLYKSLDSI-----AllYY----NPEVEKVVHRCRELPRVMLDKVESLARELKVGIEQVARENTELKRQK 306 Tasmanian devil
XP_005333070 235 MDLRNLWKDSIVSRSLETL----GYnmGYPMisHSDVISIRRTCDQMPSIMSTKVEELARSLRAGIERVARENSDLQRQK 310 thirteen-lined ...

Q9BX97       309 LEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMELAIRNSALDT 388 human
Q91VC4       306 LELERAAQAAQEARARAGTEAQARETQLRAECARQTQLALEEKAALRAQRDNLERELEARKRELEQLRTEVDVRISALDT 385 house mouse
XP_006768478 309 LEAEQALRVSQEAKEKVVKEAQAREAKLQAECARQTQLALEEKAALRKERDNQAKELEEKKREAEHLKIQLAVSNSALDT 388 Myotis davidii
XP_541953    309 LEVEQALKASQEAKEKLEKEAQAREAKLQAECARQTQLALEEKATLRKERDTLAKELEEKKRDAEQLRMQLAVSNSALDT 388 dog
ELR46074     309 LEVEQSLRASQEAKEKVEKEAQAQAVKLQAECARQTQLALEEKVALQKERDRLVKELEEKKRETEHLKLQLAVSNSALDT 388 Bos mutus
XP_003464240 313 LEAEQRVRAGQTAAEKAQQEAAQREAKFRAECSRQTDLALEEKTALRKERDALAKELEERKQQVAQLQMQVAVKSETLST 392 domestic guinea...
ELW67180     309 LEAEQNLQASQAAKEKVEKEAQGREAKLHAECARQTQLALEEKAVLRKERDNLAKELEEKKKEVEHLKMQLAVANSALDT 388 Chinese tree shrew
XP_012664866 305 LQAEQSLRASQEAKEKVEKEAQAREAKLQAECSRQTQLALEEKATLRKERDNMAKELEEKKREVEQLKMQLAVSNTALDT 384 small-eared galago
XP_003760899 307 EAGEKSLAACKEEKDKVLKETQERLQKVHEDCVKQARLALEEKVALQKEKDALKKELEEKKKELALTKGQLDINTATLET 386 Tasmanian devil
XP_005333070 311 LEAEQSLRASQEAKEQAEKEARAREAKIQAGCTQQVQLALEEKAVLRRERDNLAKELAEKKREVEQLKMQMDVRISALDT 390 thirteen-lined ...

Q9BX97       389 CIKTKSQPMMPvSRPMGPV--PNPQPIDPASLEEFKRKILESQR---PPAGIPVAPS 440 human
Q91VC4       386 CVKAKSLPAVP-PRVSGPP--PNPPPIDPASLEEFKKRILESQR---LPVVNPAAQP 436 house mouse
XP_006768478 389 CIKAKSLP-MSmPRPVAPA--PNPQPIDPASLEEFKKKILESQW---PPASNAVASs 439 Myotis davidii
XP_541953    389 CIKAKSQP-IPiPRPAGPA--PNPQPIDPAGLEEFKRRILESQR---PPAANAVAPS 439 dog
ELR46074     389 CIKAKSQLTIPgPRPAVPV--PNPPPIDPASLEEFKRRILDSQR---APASNVLVSA 440 Bos mutus
XP_003464240 393 CVKAKSQPLTP-SRAVAPV--PNPPPIDPVSLDEFRRKILESQR---GVVLQvrg-- 441 domestic guinea pig
ELW67180     389 CIKAKG------------A--GSRCPVDPASLEEFKKRILESQR---PPAGNLPAsp 428 Chinese tree shrew
XP_012664866 385 CIRAKSQP-IPlPRPVGPA--PNPPPIDPVSLEEFKKRILESQR---TSIGNPAAPS 435 small-eared galago
XP_003760899 387 CIRTKAQGSTLlPRPPVPA---KPAPLDLEALEEFKRRLMNTYQkasQPSGNPASg- 439 Tasmanian devil
XP_005333070 391 CLKAKSQS-IPlPRPVGPVpqPQPQPIDPASLEEFKKRILESQR---SPAGNPAVLS 443 thirteen-lined ground squirrel
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