3TDU,4GBA,2IS9


Conserved Protein Domain Family
Cullin_binding
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pfam03556: Cullin_binding (this model, PSSM-Id:308909 is obsolete and has been replaced by 460971)
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Cullin binding
This domain binds to cullins and to Rbx-1, components of an E3 ubiquitin ligase complex for neddylation. Neddylation is the process by which the C-terminal glycine of the ubiquitin-like protein Nedd8 is covalently linked to lysine residues in a protein through an isopeptide bond. The structure of this domain is composed entirely of alpha helices.
Links
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Statistics
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PSSM-Id: 308909
Aligned: 209 rows
Threshold Bit Score: 79.1129
Created: 18-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3TDU_A        77 KLKAQI-PKMEQEL-KEP-Gr-FKDFYQFT------FNFAKN---PGQ--KG--LDLEMAIAYWNLVLngr--------- 130 human
Q4Q0J0       118 aahdAI-VDLNNTI-RSNeEk-RSKFYQFL------YNWCLKgndASD-------RVDSAKELWSCFFsaspvsltveea 181 Leishmania major
Q4CTL1       116 AMRSHV-DEIDEVL-HKDpDq-FRKFYRFI------FGWVRSpetTARslGElgMNIATAVELWQMLFpeyk-------- 178 Trypanosoma cruzi
Q38A65       115 ALRNHV-ETLDGAL-RGDvTk-FRHFYRFI------YKWVQSpltMERnmGQvgMSIETAVELWRMLFphyr-------- 177 Trypanosoma brucei
CBN75644     150 QLRQKL-KDLRVVVdDRR-SptFREFYMFC------FEYAKE---RGK--KS--IELDVCLSVWELVLtgpe-------- 206 Ectocarpus sili...
XP_002617989 116 GMRSYI-DKQHYELrANR-Nr-FEQFYRYV------FDFVRG---RGAg-KT--LPAPDAAAYWHLLFidsmasneh--- 177 Clavispora lusi...
ETO14151     183 vvKAKL-ASLETEVq-------FRQFYKFCimfiwvFQHVKEd--EKK--KT--IPVTLAVQVWKIALgskqk------- 241 Reticulomyxa fi...
XP_001468767 117 QMRQNV-TEWVKDV-RESgGs-FLLMYNYL------YDYIR-----GEedRR--MTLTTALSAWDVFFskn--------- 171 Leishmania infa...
XP_001564670 125 QLRQKL-GEWVKDV-RESsGa-FLLMYTYM------YDYIR-----GEedRR--MTRTTAINGWDVFFgqn--------- 179 Leishmania braz...
XP_002504293  89 egLATLfSSLTREFavd--pqrFAAFYHFF------FFVARD---RGH--RN--LADATAVEGWRFLLgggr-------- 145 Micromonas sp. ...

3TDU_A       131 ---------fkfLDLWNKF-LlEH-------HKr-------sIPKDTWNLLLDFSTMIa-------dDMSNYDEEGAWPV 179 human
Q4Q0J0       182 rrkftayvcfprINQWLDF-ItMLgekatesKsgrvaveqsgVSFDTWTQLLLFArf---------dNYDAYDDEDSWPV 251 Leishmania major
Q4CTL1       179 --------tflkMNDWITF-CtTKeifh-----------reaISRDLWEQLLEFTSLT---------RYDTYDVNDAWPS 229 Trypanosoma cruzi
Q38A65       178 --------efkrLDDWITFcMsKKlfp------------hgiISRDLWEQLLEFTFVT---------DYSKYDVSDAWPS 228 Trypanosoma brucei
CBN75644     207 ---------fplLKDFSEY-LrGA-------KVp-------vVTKDMWAQTLAFFCQVd-------pDLSNFDESDAWPV 255 Ectocarpus sili...
XP_002617989 178 ----qdevlvkrVEQWCEF-VeNAar---------------pVTRDTWNMWLRFYYEVmep---apkTLAAYNEMDAWPS 234 Clavispora lusi...
ETO14151     242 --------elplLEKWIAW-CeQS-------KDvn------vVNRDVWEQVYDFLKETk--------TLNTYDDSGAWPV 291 Reticulomyxa fi...
XP_001468767 172 ----------dlYAKWKAWaVaNVkg---------------gVSRDLWRQLGIFFTMDttaaqrfgdQISAL----PWPS 222 Leishmania infa...
XP_001564670 180 ----------krYAKWKTWaVaNLtg---------------dVSRDLWRQLGIFLTMDtdatqssddQVLAL----SWPS 230 Leishmania braz...
XP_002504293 146 ---------falLEPWCAF-VrERreg------------gkgVSEDTWCQVLDFAHSCndasrggggCLDAYDPHGAWPV 203 Micromonas sp. ...

3TDU_A       180 LIDDFVEF 187 human
Q4Q0J0       252 TMDDFVVY 259 Leishmania major
Q4CTL1       230 AIDDFVEY 237 Trypanosoma cruzi
Q38A65       229 AMDDFVEY 236 Trypanosoma brucei
CBN75644     256 VVDEFVEa 263 Ectocarpus siliculosus
XP_002617989 235 LVDEYVDW 242 Clavispora lusitaniae ATCC 42720
ETO14151     292 QIDEFIAW 299 Reticulomyxa filosa
XP_001468767 223 AIADFLdq 230 Leishmania infantum JPCM5
XP_001564670 231 AIADFIEt 238 Leishmania braziliensis MHOM/BR/75/M2904
XP_002504293 204 LVDEFVDH 211 Micromonas sp. RCC299
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