Conserved Protein Domain Family
HAUS-augmin3
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pfam14932: HAUS-augmin3 (this model, PSSM-Id:291593 is obsolete and has been replaced by 464384)
HAUS augmin-like complex subunit 3
This domain is subunit three of the augmin complex found from Drosophila to humans. The HAUS-augmin complex is made up of eight subunits. The augmin complex interacts with gamma-TuRC, and attenuation of this interaction severely impairs spindle MT generation. Furthermore, we provide evidence that human augmin plays critical and non-redundant roles in the kinetochore-MT attachment and also central spindle formation during anaphase in human cells.The HAUS complex is required for mitotic spindle assembly and for maintenance of centrosome integrity.
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Statistics
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PSSM-Id: 291593
Aligned: 42 rows
Threshold Bit Score: 160.208
Created: 28-Jun-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q0WQE7        28 WPFQYDDARPILDWICSSLRPSNVLSLAELSLYEQFQRDGK-LLEGDDLDQAYDSISafsSRRNNQ--EAVFGAEESIKE 104 thale cress
Q16G91        23 WLLHDESFKEFFDWFGKSVTEDNLASDSLLREYSDLERNDL-VLSEEEVQVELELLCkdfPNILEYndDDVEIYEEQLEE 101 yellow fever mo...
XP_002055549  22 WIVYDEQFEKFFNFLSENVTDSNILTARELLERDEMMQRGE-WLQESERILKLQQIEsenPGLLKYtnQDVETLAAAVEV 100 Drosophila virilis
XP_002010566  22 WIIYDEQFEKFFNFLSENITDSNILTEREVLESEEMKQRGa-WLKESERVLKLQQIEsenPGLLKYtaHDVDALALEVEA 100 Drosophila moja...
XP_001991893  22 WIIYDERFEKFFQFLFKNISDSNILTDHELLARDEMMQHGE-WLNETERQLKLQQIEaewPGLLEHtdEDLEALSAEIEQ 100 Drosophila grim...
XP_001959134  22 WILYDEQLEKFFKFLSQDVTDANILTESQVLEREEMRRR-NeWLEESDRELKLLQIEsesPGLLKFnrQDVSGLTMEIAS 100 Drosophila anan...
XP_002074800  22 WILYDEQFERFFNFISENITDANILTEQELLERDEMVLNGN-WLDKPECELALRRIDaenPGLLKHkpQNVTALSSEIAV 100 Drosophila will...
XP_002025926  22 WLLYDEKLEKFFKYLSVSITDSNILTEQEVLERDEMQHRAN-WLTGSELQLKQQEIEaenPGLLTHtqQDVDALSAVGAA 100 Drosophila pers...
ETN61091      23 WVVHDENFRDFFDWFAK-VDDDNLITDALDKDYDELKRHDD-VYEESEVDALLKQLDtqySNILDYtdRDVTELEQQLEQ 100 Anopheles darlingi
XP_314793     23 WIIHDETFREFFDWFTK-IDDDNLVTDMLLKNYQELDRNGt-VLNDALLEEQLHALNhefSGILEHtdRDVEALELQLEQ 100 Anopheles gambi...

Q0WQE7       105 VRDATLAHKAEALELQRQLRRLQTQYDLLTGQSSALIQGRRARVAATSAVSGQITAIEDSLSARNLQMNGVLGRLAStsq 184 thale cress
Q16G91       102 LVAIEEQYEKLLADAKQTEKGLTKELSELDMQLMDAEFNQGKMATECMEKARFVEEIQSNSQQQIFDMHQCYVQAQN--- 178 yellow fever mo...
XP_002055549 101 IEEATNDYSTLIDEMQNTKHSIISKLSELESTILLLHNTEREMLVECQAKARQLEELQRENCKLSEDTNKGFTLPQ---- 176 Drosophila virilis
XP_002010566 101 IKEATKDYCILIDEMQNTKHSQSSKLSELECTILSLSNGERELLGECQAKARLLEEVQRENAKLSEEANKGFTMQQS--- 177 Drosophila moja...
XP_001991893 101 LQQATNDYNVLIDEMKNTKHSININLSELEYEIRPLQVAERELLGECQKKAGQLEQLQRHNRELVEETSREFTMQQM--- 177 Drosophila grim...
XP_001959134 101 IEEASRDYALLLEDMLNAKHSITNHLSELECAACELQSKEKELLSECQSKAKQLEELQRENCRLSGEAKKSFTTPQM--- 177 Drosophila anan...
XP_002074800 101 LEDAAHEYAVLIDDMQNSKRIITNNLNNLEYEITKLQNEGRGLIASSQTRAKQLEDLQRENCKLSIEAKKGFTSQQS--- 177 Drosophila will...
XP_002025926 101 IQEASADYASLIENMANTKQTINNNLIELECAASALQNTEKILLSDCQEKAKQLEELQSENCKLSSEAKKA--------- 171 Drosophila pers...
ETN61091     101 MVEIEEHYERLLEDAKKTDILLTKELTDIERATIDAQYLMEKQEKSCLTLGKRLEENQLITQQKIADLHHCYLQPQN--- 177 Anopheles darlingi
XP_314793    101 LVEVEEKYEKLLNGAKKTDLALTKELSELERSVRDQEYVLEKVATNSVEMARQLEESQQATQQQISDLQHCYYQRQN--- 177 Anopheles gambi...

Q0WQE7       185 elahYHSGEEDGIYLAYSDFHAYLAGDSACTKELNQWFAKQLDtgPYRLVAEEGkskcswvslddtsnmlrDLEKSq-HQ 263 thale cress
Q16G91       179 ----------PPLFVYQMPIEQFNMKCDQFLKYLEMYIRKHFS--VRNLDDSE------------------HEPDQsqRD 228 yellow fever mo...
XP_002055549 177 ---------VPPLFMHQMPLDQYFLKCDSFMQYFTLYMKENFK--IQELIDFE-------------------SAEVdvQH 226 Drosophila virilis
XP_002010566 178 ----------PPLFMHQMPLEQYFLKCDSFMQYFTLYMKENFK--IQEFTEFED-------------------AEVnmQH 226 Drosophila moja...
XP_001991893 178 ----------PPLFMHQLPLDQYFLKCDSFLQYFTLYMKDNFK--IQEYAEFE-------------------SIDVdiQQ 226 Drosophila grim...
XP_001959134 178 ----------PPLFMHQLPLEQYFLKCDSFMQYFTLYVKENFK--IQEYDEFQ-------------------IAENdfLH 226 Drosophila anan...
XP_002074800 178 ----------PPVFMHQQPLEQYFLKNDSFVQYFNLYLKENFK--IQDNQDFQNslv------------------ddmEV 227 Drosophila will...
XP_002025926 172 ----FISEPMPQLFMHQLPLEHYFLKCDSFMQYFTLYIKENFKiqkn---------------------nefSTAEVniLH 226 Drosophila pers...
ETN61091     178 ----------PPLFVYQMPIEQFDAKCDQFLKYLQMYVKKHFP--VRHLEGFK------------------SSTELsnSE 227 Anopheles darlingi
XP_314793    178 ----------PPLFIYQMPIDQFDAKCDQFLKYLELYVKKHFT--VKRLDNSK------------------STDDGdnQQ 227 Anopheles gambi...

Q0WQE7       264 RVAELQRLRSIFGTSERQWIEAQVE 288 thale cress
Q16G91       229 IIIQLESIKSRLDVEEGKLTDASKE 253 yellow fever mosquito
XP_002055549 227 FNSKLENLQNSIQYYTLEYIKEKAK 251 Drosophila virilis
XP_002010566 227 FNSNLENLQKSIQYHTLEYIKEKAK 251 Drosophila mojavensis
XP_001991893 227 MNSKLENLQNSMEYYTLAYIkkkat 251 Drosophila grimshawi
XP_001959134 227 EKHKLEDLQNGIQHYALSYIRHKAK 251 Drosophila ananassae
XP_002074800 228 ANSNLEVLQNSLEFYTiaiikkkik 252 Drosophila willistoni
XP_002025926 227 EKEKLESLERGIQYYalafikkkak 251 Drosophila persimilis
ETN61091     228 VLDELEDIKLRLDVEELKLLEEKRE 252 Anopheles darlingi
XP_314793    228 VIDELEGIKMRldeeelklleakre 252 Anopheles gambiae str. PEST
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